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Physicians Still Hopeful About Desmoteplase for the Treatment of Acute Ischemic Stroke Despite Negative Results
Date:1/30/2008

Surveyed Neurologists Identify a Six-Hour Treatment Window as Area of Greatest Dissatisfaction, According to a New Report from Decision Resources

WALTHAM, Mass., Jan. 30 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that physicians are still hopeful about Paion/Lundbeck's desmoteplase despite recent negative results. Although desmoteplase demonstrated efficacy on a stringent composite measure of overall outcome when delivered within nine hours of stroke onset in the DIAS-1 trial, the drug failed to meet the same efficacy outcome in the larger DIAS-2 Phase III clinical trial. Experts interviewed by Decision Resources suggest that issues of clinical trial design, rather than the action of the drug, may have led to the failure of desmoteplase in the DIAS-2 trial. Despite these findings, surveyed neurologists indicate that they would prescribe the drug to 10% of their diagnosed acute ischemic stroke patients.

According to the new report entitled: Acute Ischemic Stroke: Despite Negative Results, Physicians Still Hopeful about Desmoteplase, surveyed neurologists continue to identify a six-hour treatment window as the area of greatest dissatisfaction. The development of a reperfusion agent with a wider time window would represent an important near-term solution by increasing the number of acute ischemic stroke patients who receive treatment.

"Between the two emerging therapies included in this study, desmoteplase appears to have the potential to meet many of the safety and delivery criteria of our 'Minimal Acceptable' target product profile," said Sami Fam, Ph.D., analyst at Decision Resources. "Surveyed neurologists would treat 10% of their patients with such an agent -- that is three times more than those who are getting treated currently with rt-PA. The arrival of such a reperfusion agent would signal a new dawn for the treatment of acute ischemic stro
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SOURCE Decision Resources
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