Navigation Links
Phylonix granted broad European patent for transplanting human cells into zebrafish
Date:12/18/2007

Cambridge, MA -- December 18, 2007 -- Phylonix Pharmaceuticals today announced that it recently received a broadly issued European patent EP 1 135 531 B1: Methods for Introducing Heterologous Cells into Fish. The patent, which has issued in key European countries, encompasses 68 claims, including transplanting stem cells, cancer cells and pathogens. In addition, neurons, chondrocytes, renal and hepatic cells can be transplanted in zebrafish and effects of growth factors or cytotoxic agents can be assessed. Claims also cover recovering cells for potential tissue engineering or transplantation applications. Many of these claims have issued previously in the United States and other countries.

This award complements our previously issued patents for assessing angiogenesis, apoptosis and toxicity in zebrafish, and use of high-throughput screening methods such as microplate analysis, commented Patricia McGrath, Phylonix President and Chief Executive Officer.

Cells that proliferate in their native environment also proliferate when transplanted into zebrafish; cells that are incapable of proliferating in their native environment usually do not proliferate in zebrafish.

Advantages of Zebrafish for Transplantation

Currently, the mouse is the model system of choice for cell transplantation assays. However, to prevent cell rejection, transplantation of human cells must be performed using immunosuppressed mice and these animals are expensive to develop and maintain. In comparison, cell transplantation in zebrafish larvae is simple and cost effective, and immunosuppression is not necessary.

There are several additional advantages of using zebrafish for transplantation assays. All essential components of vertebrate form and organ development are mimicked in the transparent zebrafish and their molecular basis is either identical or similar, underscoring the potential for use in research on human diseases. Due to the small size of zeb
'/>"/>

Contact: Edward O'Lear
ed.olear@phylonix.com
617-441-6700
Phylonix Pharmaceuticals
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards Phylonix phase II SBIR to develop zebrafish models for eye diseases
2. PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism
3. Abbott Broadens Use of i-STAT Handheld Blood Analyzer with CLIA Waiver Granted by FDA for CHEM8+ Test Cartridge
4. USC granted $8.4 million for autism research
5. Aida Granted Additional Anti-Cancer Patent
6. CME LLC Granted Five-Year Full Approval by the American Psychological Association
7. ActiPatch(TM) Granted Market Clearance by the Food & Drug Administration in the Kingdom of Jordan
8. TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA
9. Neurochem announces eprodisate (KIACTA(TM)) receives acknowledgement of complete response and is granted Class 2 review
10. Isis Announces ISIS 333611 Granted Orphan Drug Status for Treatment of ALS
11. Broad-based group of physicians calls for improvement in stroke treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 ... can receive effective, less expensive care from a clinic that ... team of dedicated health care professionals, a new study shows. ... need either hospitalization or a trip to the emergency room ... at the University of Texas in Houston versus usual care, ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... could be closing in on a "fountain of youth" drug ... health of older adults, a new study suggests. Seniors ... a drug that targets a genetic signaling pathway linked to ... report. The experimental medication, a version of ...
(Date:12/25/2014)... Viejo, California (PRWEB) December 25, 2014 ... release of ProFire 5k. A fully customizable business presentation ... . , “Adding the ProFire 5k business tool, users ... Said Christina Austin, CEO of Pixel Film Studios. “ProFire ... look and style to add professionalism to a presentation” ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those in ... the holiday season, AlignLife looks forward to their annual toy ... Sara Mahalko-Leonhardt, owner of AlignLife. "It brings our patients as ... are able to give kids toys for Christmas who would ... generosity of our patients." , The 70 toys were donated ...
(Date:12/24/2014)... 25, 2014 Recently, iFitDress.com, a famous dress ... prom dresses under $150 . All these items are brand ... website has already been updated with the new range of ... ordered so far. All iFitDress.com’s designs are made according to ... using great materials. Every outfit from the company is handpicked ...
Breaking Medicine News(10 mins):Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2
... Dec. 11 Emerging Growth Equities, Ltd. initiates coverage ... BUY rating and a $9.00 price target. PolyMedix ... serious, life-threatening acute disorders. The Company,s leading clinical ... antagonist PMX-60056. , , ...
... training to ease their lower back pain are better off ... jogging, according to a University of Alberta study. , The ... a 60 per cent improvement in pain and function levels ... 16-week exercise program of resistance training using dumbbells, barbells and ...
... Nutritional Supplements,has developed a new revolutionary appetite and weight ... their desire to eat,and reduce their food intake, it ... less but still feel satisfied. Additionally, Trimma(TM),comes in an ... their chocolate and sweet cravings. , ...
... nation is facing, call center outsourcing services provider Outsourcing City remains ... to further save on its investments, the company is now offering ... telemarketing services. , ... Brea, CA (PRWEB) December 11, ...
... Human Immunology Center (RHIC) has been awarded a $4 ... of Allergy and Infection Disease (NIAID). The renewal enables ... a worldwide effort to standardize how researchers use complex ... discovery of new treatments. , When standardization ...
... Dec. 11 Intellx Inc. announces a 50%,price cut ... Intellx is one of four major condom makers ... USA, Inspiral(R). , ... Brian,Osterberg, "and the coalescence of growing popularity of our ...
Cached Medicine News:Health News:Emerging Growth Equities, Ltd. Initiates Coverage of PolyMedix Inc. With a Buy Rating and a $9.00 Price Target 2Health News:Trimma(TM) Now Available in the United States for People Looking for a Delicious Way to Control Their Calories 2Health News:Free Trial of Call Center Outsourcing Services and Performance Based Telemarketing from Outsourcing City 2Health News:Free Trial of Call Center Outsourcing Services and Performance Based Telemarketing from Outsourcing City 3Health News:Immunology Center will continue to drive standard methods, better science 2Health News:Immunology Center will continue to drive standard methods, better science 3Health News:Immunology Center will continue to drive standard methods, better science 4Health News:Immunology Center will continue to drive standard methods, better science 5Health News:Intellx Bails Out Safe Sex 2
(Date:12/24/2014)... DUBLIN and RALEIGH, N.C. ... subsidiary of Endo International plc (NASDAQ: ENDP ... BDSI ) announced today that they have ... Buccal Film to the U.S. Food and Drug Administration ... the management of pain severe enough to require daily, ...
(Date:12/22/2014)... Apnea Sciences ( www.apneasciences.com ) announced it ... Aliso Viejo , California.  Jimmy Fallon , ... and worldwide expansion, a new facility with expanded infrastructure ... snore cure have exceeded our expectations and thus required ... in 23 countries and will be increasing to 39 ...
(Date:12/22/2014)... LUXEMBOURG , Dec. 22, 2014  ConvaTec, a ... Paul Moraviec has been appointed Interim Chief Executive Officer ... Mr. Moraviec succeeds Ken Berger .  "The Board ... service in leading ConvaTec over the past three years," ... Board of Directors.  "We are confident that the company ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2
... , NASHVILLE, Tenn., Oct. 27 Cumberland Pharmaceuticals Inc. ... report third quarter 2009 financial results before the market opens ... live Internet webcast will be held on Tuesday, November 10, ... , To participate on the call, please dial 888-417-8462 (for ...
... Denver ophthalmologist recently became the first in Colorado to implant ... bar for patient care in the state while increasing the ... director of Cutarelli Vision in Denver and Fort Collins, said ... eye of a 70-year-old man whose cataracts in his left ...
Cached Medicine Technology:Cumberland Pharmaceuticals to Announce Third Quarter 2009 Financial Results on November 10, 2009 2Denver-Ft. Collins Ophthalmologist First in Colorado to Implant nanoFLEX Lens 2Denver-Ft. Collins Ophthalmologist First in Colorado to Implant nanoFLEX Lens 3
... IMMULITE 2000 assays are ... the IMMULITE 2000, a ... immunoassay analyzer. IMMULITE 2000 ... centralization, and a rapidly ...
... CARDIAC M Myoglobin assay for use ... The Cardiac reader analyzer is a ... include: always ready to use (stand-by ... batch specific data entered automatically using ...
IRMA kit for detection of the cardiac marker Myoglobin...
... The CALBIOTECH INC. (CBI) Prolactin ELISA kit ... prolactin in human serum or plasma. Human ... polypeptide hormone with a molecular weight of ... based on a solid phase direct sandwich ...
Medicine Products: