Navigation Links
Phylonix granted broad European patent for transplanting human cells into zebrafish
Date:12/18/2007

Cambridge, MA -- December 18, 2007 -- Phylonix Pharmaceuticals today announced that it recently received a broadly issued European patent EP 1 135 531 B1: Methods for Introducing Heterologous Cells into Fish. The patent, which has issued in key European countries, encompasses 68 claims, including transplanting stem cells, cancer cells and pathogens. In addition, neurons, chondrocytes, renal and hepatic cells can be transplanted in zebrafish and effects of growth factors or cytotoxic agents can be assessed. Claims also cover recovering cells for potential tissue engineering or transplantation applications. Many of these claims have issued previously in the United States and other countries.

This award complements our previously issued patents for assessing angiogenesis, apoptosis and toxicity in zebrafish, and use of high-throughput screening methods such as microplate analysis, commented Patricia McGrath, Phylonix President and Chief Executive Officer.

Cells that proliferate in their native environment also proliferate when transplanted into zebrafish; cells that are incapable of proliferating in their native environment usually do not proliferate in zebrafish.

Advantages of Zebrafish for Transplantation

Currently, the mouse is the model system of choice for cell transplantation assays. However, to prevent cell rejection, transplantation of human cells must be performed using immunosuppressed mice and these animals are expensive to develop and maintain. In comparison, cell transplantation in zebrafish larvae is simple and cost effective, and immunosuppression is not necessary.

There are several additional advantages of using zebrafish for transplantation assays. All essential components of vertebrate form and organ development are mimicked in the transparent zebrafish and their molecular basis is either identical or similar, underscoring the potential for use in research on human diseases. Due to the small size of zeb
'/>"/>

Contact: Edward O'Lear
ed.olear@phylonix.com
617-441-6700
Phylonix Pharmaceuticals
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards Phylonix phase II SBIR to develop zebrafish models for eye diseases
2. PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism
3. Abbott Broadens Use of i-STAT Handheld Blood Analyzer with CLIA Waiver Granted by FDA for CHEM8+ Test Cartridge
4. USC granted $8.4 million for autism research
5. Aida Granted Additional Anti-Cancer Patent
6. CME LLC Granted Five-Year Full Approval by the American Psychological Association
7. ActiPatch(TM) Granted Market Clearance by the Food & Drug Administration in the Kingdom of Jordan
8. TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA
9. Neurochem announces eprodisate (KIACTA(TM)) receives acknowledgement of complete response and is granted Class 2 review
10. Isis Announces ISIS 333611 Granted Orphan Drug Status for Treatment of ALS
11. Broad-based group of physicians calls for improvement in stroke treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... 30, 2014 In today’s world, a good ... get. Snoring and sleep apnea (a medical problem where the ... their bed partners of the rest they need to face ... population snores and 20 million people in the United States ... diagnosed and treated; and of those treated, many cannot tolerate ...
(Date:8/30/2014)... New Delhi, India (PRWEB) August 30, 2014 ... the online reputation management industry, has announced to offer ... Removecomplaints.net has decided to offer this guarantee because of ... for more than 200 clients from all over the ... for doing extremely good job. , On being ...
(Date:8/30/2014)... NY (PRWEB) August 30, 2014 When a ... quickly ensue, as happened on Wednesday, August 27th, when news ... attack on JPMorgan Chase & Co and at least ... FBI is actually investigating attacks on seven prominent banks ... they may be affected, and the buzz quickly goes viral. ...
(Date:8/30/2014)... FL (PRWEB) August 30, 2014 Zensah®, the ... Camo Compression Leg Sleeve . The camo sleeves are ... Leg Sleeve collection. The camo line includes classic colors ... and magenta. , Known as tibial stress syndrome, shin ... of the lower leg. Swollen and irritated muscles, stress fractures, ...
(Date:8/30/2014)... CT (PRWEB) August 30, 2014 ... national observance that educates Americans about the fact ... by recovery, from alcohol and drug addiction and ... organizations join with treatment providers, prevention programs and ... heals individuals, families, workplaces and neighborhoods. The ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Removecomplaints.net Announces Guaranteed Complaints Removal Services 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 3Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 4Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 5Health News:Camo Compression Leg Sleeves Provide Shin Splint Relief for Runners 2Health News:September is National Recovery Month: What the Connecticut Community for Addiction Recovery (CCAR) Wants You to Know 2Health News:September is National Recovery Month: What the Connecticut Community for Addiction Recovery (CCAR) Wants You to Know 3
... on heavier children may miss the target, study finds ... testing guidelines for children may have to be revised, ... an effective indicator of high cholesterol in kids. , ... revised cholesterol screening guidelines that recommended a cholesterol check ...
... of IgM foretells serious cardiovascular issues: study , ... that immunoglobulin M (IgM) is a reliable predictor of ... have diabetic nephropathy (DN) -- kidney damage caused by ... followed from 1984 to 2007. Those with increased levels ...
... , , MORGANTOWN, W.Va., Aug. 7 ... rooms finds that homeless patients are more likely to arrive at ... be uninsured. , , One-third of homeless patients ... million, according to the researchers. , , Analyzing ...
... , WHEATON, Ill., Aug. 7 ... grant in the amount of $15,000. The grant is specifically ... classes for children with physical or developmental disabilities or delays. ... their motor, sensory, play, communication and social skills, thereby encouraging ...
... study options , FRIDAY, Aug. 7 (HealthDay News) -- Only ... used by researchers in the United States, says a new study. ... and H9, accounted for 941 of 1,217 requests, or 77 percent, ... housed at the two largest stem cell banks in the country. ...
... at processing new information at 6- and 12-months-old, ... young adults in their 20,s, according to ... Joseph Fagan. Fagan,s "The prediction, from infancy, of ... Intelligence , is receiving accolades. Mensa International, Limited,- the ...
Cached Medicine News:Health News:Cholesterol Screening Shouldn't Rely on Kids' Weight 2Health News:Immunoglobulin Can Predict Some Diabetic Complications 2Health News:Researchers Produce First Nationwide Study of Homeless in ERs 2Health News:DuPage Community Foundation Awards $15,000 Grant to Marianjoy Pediatric Continuing Care Program 2Health News:DuPage Community Foundation Awards $15,000 Grant to Marianjoy Pediatric Continuing Care Program 3Health News:U.S. Stem Cell Research Seems to Focus on Two Lines 2Health News:Ability to process information as a baby continues into adulthood 2
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "Research and Development Trend Forecast of Pharmaceutical Equipment Market ... Research and Development Trend Forecast of Pharmaceutical ... mainly analyzes China,s pharmaceutical equipment ... & demand, competition landscape, and business performance of domestic ...
(Date:8/29/2014)... -- According to the new research ... Reagent, Primer, Probe, Custom Oligos), End-User (Research, Pharmaceutical ... NGS, DNA, RNAi) - Global Forecast to 2019" ... is expected to reach $1,712.1 Million by 2019 ... CAGR of 9.8% from 2014 to 2019.. ...
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire-iReach/ -- ChemImage will present ... Australian and New Zealand Forensic Science Society,s 22 ... in Adelaide, Australia .  Forensic ... the advancements that hyperspectral imaging can bring to ... Beckstead , Director of Product Development at ChemImage, ...
Breaking Medicine Technology:Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3
... Mass. and SYDNEY, Nov. 4 HeartWare International, Inc. ... and provider of less invasive, miniaturized circulatory support technologies ... a significant increase in revenues to $7.5 million for ... to approximately $3.0 million in revenues in the second ...
... 4 Sanford Wittels & Heisler, LLP, along with ... medical device company specializing in cardiac surgical ablation systems, ... of Justice (DOJ) in a qui tam case filed ... five-year period. , Sanford Wittels & Heisler and Grant ...
Cached Medicine Technology:HeartWare International Reports Third Quarter Revenues of $7.5 Million 2HeartWare International Reports Third Quarter Revenues of $7.5 Million 3HeartWare International Reports Third Quarter Revenues of $7.5 Million 4HeartWare International Reports Third Quarter Revenues of $7.5 Million 5HeartWare International Reports Third Quarter Revenues of $7.5 Million 6HeartWare International Reports Third Quarter Revenues of $7.5 Million 7Relator's Attorneys Comment On AtriCure/DOJ Proposed Settlement 2
... Quinton Q-Stress Cardiac Stress Monitor ... wander and muscle artifact filters, ... to provide the highest ECG ... can be displayed in 3, ...
... the stress testing system from Del Mar ... including treadmill or bicycle ergometer, PC, Cart, ... It uses the same CardioDirect patient interface ... ,The system is also available ...
... A breakthrough in non-invasive cardiac diagnosis, ... is the first and only stress test ... microvolt level. The pre-test lead check provides ... the WAVESTAR ECG filter that dynamically filters ...
... integrated exercise stress system, the Quest, combines ... Combined with a 15" color monitor, users ... the screen to program or select specific ... user with LogiStep, highlighting the step usually ...
Medicine Products: