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Photo: Levemir(R) Once-Daily Substantially Lowered Average Blood Sugar Levels of Patients with Type 2 Diabetes in TITRATE(R) Study
Date:5/8/2009

rs. The study showed that Levemir(R) taken once-daily substantially lowered patients' A1C levels after 20 weeks for both FPG targets tested.

In the study, 64.3 percent of patients in the 70-90 mg/dL FPG target treatment group and 54.5 percent of patients in the 80-110 mg/dL FPG target group reached the ADA recommended A1C level of less than 7 percent. A1C levels in the 70-90 mg/dL group decreased by 1.2 percent to an average A1C of 6.77 percent; A1C levels in the 80-110 mg/dL group decreased by 0.9 percent to an average A1C level of 7 percent.

"Good blood sugar control is important in managing diabetes, and the more active a role patients can play, the better," said Alan Moses, Vice President and Global Chief Medical Officer at Novo Nordisk. "This study is exciting because it showed that Levemir(R) at a once-daily dose helped these patients manage their condition, and in doing so, helped them achieve substantial A1C reductions."

Rates of minor hypoglycemic events were low and comparable between the two treatment groups (5.09 vs 3.16 events/patient/year in the 70-90 mg/dL and 80-110 mg/dL FPG target treatment groups, respectively). A single major hypoglycemic event (requiring third party assistance) was reported by a patient in the 70-90 mg/dL FPG target treatment group. More details about the study can be found in the journal. Prescribing information for Levemir(R) is available by contacting Novo Nordisk or visiting novonordisk-us.com.

About the Study

The open-label TITRATE(R) study was a prospective, randomized, controlled study to examine the effect of patients self dosing of Levemir(R) once-daily using two FPG targets on blood sugar control. In the study, 244 type 2 diabetes patients taking oral antidiabetes drugs, who had never before used insulin, were assigned to one of two treatment groups: using 70-90 mg/dL or 80-110 m
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SOURCE Novo Nordisk
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