Navigation Links
Phases of clinical depression could affect treatment
Date:8/4/2014

Research led by the University of Adelaide has resulted in new insights into clinical depression that demonstrate there cannot be a "one-size-fits-all" approach to treating the disease.

As part of their findings, the researchers have developed a new model for clinical depression that takes into account the dynamic role of the immune system. This neuroimmune interaction results in different phases of depression, and has implications for current treatment practices.

"Depression is much more complex than we have previously understood," says senior author Professor Bernhard Baune, Head of Psychiatry at the University of Adelaide.

"Past research has shown that there are inflammatory mechanisms at work in depression. But in the last 10 years there has been much research into the complexities of how the immune system interacts with brain function, both in healthy brains and in people experiencing depression.

"Unfortunately, much of the research is contradictory and in asking ourselves why, we undertook a review of all the studies conducted to date on these issues.

"This has led us to the conclusion that there are different immune factors at work in depression depending on the clinical phase of depression, and that the genes for this immune response are switched on and off at different times according to phases.

"What we see in the clinical states of acute depression, relapse, remission, and recovery is a highly complex interaction between inflammatory and other immunological cells, brain cells and systems.

"This new model helps us to overcome the simplistic notion that depression is the same kind of disease for everyone, behaving in the same way regardless of the timing of the disease. We can now see that depression is a much more neurobiologically dynamic disease, and this has many implications for both research and treatment," Professor Baune says.

Professor Baune says clinicians and patients alike should be aware that common treatments for depression may, at times, not work based on this new understanding of neuroimmune phases in the disease.

"We are urging caution on the use of blanket anti-inflammatory medication for the treatment of depression. This treatment may need to be tailored according to the phase of illness a patient is undergoing, and this would require an immune profile of the patient prior to treatment," Professor Baune says.


'/>"/>
Contact: Professor Bernhard Baune
bernhard.baune@adelaide.edu.au
61-882-225-141
University of Adelaide
Source:Eurekalert

Related medicine news :

1. AED.com Presents 3 Phases of Emergency Planning for Cardiac Arrest
2. ALS patients differ on treatment choices in later phases of disease
3. ‘More Promising Mesothelioma Clinical Trials than Ever Before,’ Says Expert
4. $1.6 million NCI grant to CWRU trains nurses to increase participation in clinical trials
5. Clinical Issues in Primary Care Continuing Medical Education (CME) Conference - October 13-17, 2014 in Maui, Hawaii - Agenda Released
6. DS107G-01 – Successful Completion of Phase I Oral DGLA Clinical Trial
7. Amanda Leto’s Fibroids Miracle Review Reveals Clinically Proven Uterine Fibroids Cure System
8. Clinical Documentation Improvement Heats Up as Half of US Hospitals Make 2015 Preparations for ICD-10, the Rest to Rely on Outsourcers, Black Book Survey Reveals
9. Pharma Clinical Trials Market in China: Authorities for Drug New Study Now Available at MarketReportsOnline.com
10. Global E-Clinical Solution Software Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020
11. BruxZir® Solid Zirconia Surpasses Five Years of Clinical Use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... , ... December 08, 2016 , ... ... the Affordable Care Act. Dr. Botelho advocates for the mass media launching of ... gives people ongoing opportunities to share their unfortunate experiences; such a movement can ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... financial planning services from offices headquartered in Little Rock, has initiated a charity ... According to the National Foundation to End Senior Hunger, Arkansas ranks first in ...
(Date:12/8/2016)... AL (PRWEB) , ... December 08, 2016 , ... ... and financial planning services from offices headquartered in Jefferson County, is announcing the ... Woman’s Shelter in Birmingham. , The number of homeless women and children in ...
(Date:12/8/2016)... ... December 08, 2016 , ... Coppin Insurance Agency, an insurance and ... and around the Cape Coral area, is embarking on a charity drive with the ... Florida. , The Harry Chapin Food Bank of Southwest Florida works to provide fresh ...
(Date:12/8/2016)... Fort Payne, AL (PRWEB) , ... December 08, ... ... enterprise offering insurance and financial consulting services to residential and commercial clients in ... raise awareness and support for Nobis Works. , Since 1977, Nobis Works has ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... PHOENIX , Dec. 8, 2016 A ... by the National Institutes of Health (NIH) to ... State University.  The grant will seek ... NeuroEM,s head device, which utilizes electromagnetic waves to treat ... of this novel technology to possibly treat other neurologic ...
(Date:12/8/2016)... , Dec. 8, 2016  Boehringer Ingelheim announced ... Corporate Equality Index (CEI). This is the ninth time ... been designated as a Best Place to Work for ... the CEI is a national benchmarking report on corporate ... gay, bisexual and transgender (LGBT) employees. ...
(Date:12/8/2016)... 8, 2016 According to a new market research ... Fetal), Therapeutic (Pain, Insulin)), End Use (Sports, Fitness, RPM), Type (Smart watch, ... the global market, in terms of value, is projected to reach 12.14 ... of 18.0% during the forecast period. Continue ... ...
Breaking Medicine Technology: