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Phase III efficacy data on bevacizumab plus chemotherapy in early breast cancer to be presented
Date:12/10/2010

this treatment plus bevacizumab.

After the first four cycles, the researchers performed an interim assessment; 24 percent of patients treated without bevacizumab and 17 percent of patients treated with bevacizumab showed no response and were discontinued from treatment.

Interim safety data from the trial, published earlier this year, indicated that treatment with bevacizumab was feasible. Patients assigned bevacizumab experienced more leukopenia, infections, mucositis and hypertension, but less edema. This safety profile is no different from that reported in first-line metastatic trials or Phase II adjuvant trials of bevacizumab, according to von Minckwitz.

Full results on the histological response and surgical outcome will be reported during the symposium.

"The results will provide an important signal as to whether bevacizumab will be effective as an adjuvant treatment," said von Minckwitz.


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Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

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