Navigation Links
Phase III efficacy data on bevacizumab plus chemotherapy in early breast cancer to be presented
Date:12/10/2010

SAN ANTONIO Results of the GeparQuinto study, randomized Phase III efficacy data on the use of bevacizumab plus chemotherapy to treat women with early breast cancer will be presented at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium.

Gunter von Minckwitz, M.D., Ph.D., managing director of the German Breast Group, and colleagues are conducting final analyses on efficacy data from this study, which will detail the early treatment of more than 1,900 patients with HER2-negative breast cancer treated with chemotherapy with or without bevacizumab.

"So far, no efficacy data from Phase III trials have been reported for early breast cancer. This will be the first," said von Minckwitz. "If the pathological complete response rate is higher with bevacizmab than without bevacizumab, it will provide a new option to improve neoadjuvant treatment in HER2-negative breast cancer."

Bevacizumab is currently approved in the United States in combination with paclitaxel for the first-line treatment of metastatic breast cancer. In July 2010, the Food and Drug Administration's Oncologic Drugs Advisory Committee voted 12 to 1 to eliminate this indication from the treatment label of bevacizumab.

"A negative or positive result might have a significant effect on this picture," said von Minckwitz. "However, pathological response as a surrogate for outcome is only confirmed for chemotherapy. Long-term follow up, as well as results from adjuvant studies have to be awaited."

The researchers investigated whether adding bevacizumab to treatment with four cycles of epirubicin/cyclophosphomide, followed by four cycles of docetaxel improved the rate of pathological complete response, which was defined as no invasive or non-invasive residual cancer in the breast or nodes.

Between May 2007 and June 2010, 944 patients were assigned chemotherapy treatment with epirubicin/cyclophosphamide followed by docetaxel; 945 patients were assigned
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements
2. New High Purity Immunoglobulin Enters Phase III in Europe and the US
3. Poniard Pharmaceuticals Presents Positive Survival Data from a Phase 2 Clinical Study of Picoplatin in Metastatic Prostate Cancer at the 2010 American Society of Clinical Oncology Genitourinary Cancers Symposium
4. Nuvo Research enrolls first patient in Phase 2 WF10 allergic rhinitis trial
5. Askthedoctor.com Makes Medical Information More Accessible to the Public by Completing Phase 1 of US Expansion
6. Intellicate Announces New “Phased Return to Work” (PRtW) Service
7. Southampton scientists begin Phase II patient trial for new asthma treatment
8. Pilot Testing Phase Ends; Expansion Of Sales Force Begins
9. New phase II study supports potential of gs-9450 as new treatment option for steatohepatitis
10. Phase II study of an oral therapy for Gaucher disease yields positive results
11. Accumed Research Associates Expands Capabilities In Phase I and Bioequivalence Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2015)... As the great passage beyond midlife ... meaning, more substantial roles and connections that span the ... live a life that still matters? As The Aspen ... Next Year Total Immersion Retreat , answers to these ... results and jump-starts a healthier life. A new round ...
(Date:2/26/2015)... Imagine a day without access to clean, ... and there was no one to help. For more than ... In 2015, more than 2.5 billion people will also lack ... A new initiative led by Nevada’s Desert Research Institute ... specifically on women – who often bear the brunt of ...
(Date:2/26/2015)... The COR HEALTH division of Vets Access, ... to offer customers a full line of Topricin® pain ... and effectively address muscle, joint, and nerve pain. ... LLC, Montrose, MI, that is dedicated to providing natural, ... is a research and development leader in topical natural ...
(Date:2/26/2015)... 26, 2015 The Reproductive Science Center ... newly renovated office in Lawrenceville, NJ. , ... of New Jersey’s physicians, and NJ Top Docs, have ... in the areas of infertility and reproductive medicine. This ... success rates and providing current, high quality medical treatments ...
(Date:2/26/2015)... CA (PRWEB) February 26, 2015 Beckman ... “Diversity of extracellular vesicles and their cargo in cell-to-cell ... vesicles and their relevance for cell-to-cell communication. The webinar ... March 4, 2015 at 8:00am PT. , Every cell ... extracellular vesicles (EVs) , often called “exosomes” or “microvesicles.” ...
Breaking Medicine News(10 mins):Health News:The Aspen Club on Actively Aging: Telling a New Story on Aging 2Health News:DRI launches Global Initiative to Provide Women in Developing Countries with Clean Water 2Health News:DRI launches Global Initiative to Provide Women in Developing Countries with Clean Water 3Health News:COR HEALTH Division of Vets Access Partners with Topical BioMedics to Provide Natural Pain Relief Products 2Health News:COR HEALTH Division of Vets Access Partners with Topical BioMedics to Provide Natural Pain Relief Products 3Health News:RSCNJ Is Celebrating the Reopening of Their Newly Renovated Office 2Health News:RSCNJ Is Celebrating the Reopening of Their Newly Renovated Office 3Health News:Beckman Coulter Webinar Series Presents Diversity of Extracellular Vesicles and Their Cargo in Cell-to-cell Communication 2Health News:Beckman Coulter Webinar Series Presents Diversity of Extracellular Vesicles and Their Cargo in Cell-to-cell Communication 3
... are addicted to glucose to generate their energy, but new ... rely on fatty acid metabolism to grow and to evade ... cells vulnerable to drugs that force them to commit suicide, ... Center and The University of Texas Medical School at Houston ...
... be a problem among today,s youth. While many children ... prevalent in children that are different from the social ... of bullying, research shows a high rate of sexual ... A new study conducted by doctors at Nationwide Children,s ...
... ... Center to provide financial assistance to breast cancer patients. , ... Mesa, AZ (PRWEB) January 27, 2010 -- ... Inc. to launch a vehicle and boat donation program. The Processing Center allows TBCS ...
... , , Society of Interventional Radiology Member ... A. Nemcek Jr., M.D., FSIR, in January 2011 ... Ziv J Haskal, M.D., FSIR, has been named editor of the ... Radiology (JVIR)—for a five-year term beginning in January 2011 . ...
... and Centre for Molecular Medicine and Therapeutics have uncovered ... in Huntington,s disease, and identified a possible treatment for ... published online today and will appear in the January ... Huntington,s disease is an inherited degenerative brain disease that ...
... ... why your company should win. , ... Valencia, CA (Vocus) Jan. 27, 2010 -- U.S. HealthWorks Medical Group, a leading nationwide ... businesses who want to offer an added employee benefit by getting workers vaccinated against H1N1., ...
Cached Medicine News:Health News:Researchers find leukemia cells metabolize fat to avoid cell death 2Health News:Researchers find leukemia cells metabolize fat to avoid cell death 3Health News:Study examines sexual orientation and bullying among adolescents 2Health News: The Breast Cancer Society Launches Vehicle Donation Program 2Health News: The Breast Cancer Society Launches Vehicle Donation Program 3Health News:New Editor Named for Prestigious Journal of Vascular and Interventional Radiology 2Health News:New Editor Named for Prestigious Journal of Vascular and Interventional Radiology 3Health News:New Editor Named for Prestigious Journal of Vascular and Interventional Radiology 4Health News:New Editor Named for Prestigious Journal of Vascular and Interventional Radiology 5Health News:Discovery of mechanism in brain cell injury in Huntington's offers new treatment approaches 2Health News:Twitter Contest: Free, Onsite H1N1 Vaccination Day for Winning Businesses 2
(Date:2/26/2015)... 2015  MEI Pharma, Inc. (Nasdaq: MEIP ), ... therapies for cancer, announced today that Daniel P. Gold ... the Cowen and Company 35 th Annual Health Care ... time from the Boston Marriott Copley Place. A live webcast ... A replay will be available approximately one hour after the ...
(Date:2/26/2015)... , February 26, 2015 ABIVAX, a ... human vaccines, today announced that it has dosed in ... Phase IIb/III clinical trial of ABX203 which is taking place ... region. The study is designed to assess whether ABX203 can ... B (CHB) via controlling viral load for a much longer ...
(Date:2/26/2015)... Feb. 26, 2015 ANSYS (NASDAQ: ... manufacturer of diesel engines and global power leader, Cummins ... broad access to the ANSYS ® portfolio. This ... solve some of the industry,s most challenging multiphysics problems ... innovative products on the market. The multi-year ...
Breaking Medicine Technology:MEI Pharma to Present at Cowen and Company Health Care Conference 2MEI Pharma to Present at Cowen and Company Health Care Conference 3ABIVAX Recruits First Patient in a Pivotal Phase IIb/III Clinical Trial with ABX203, a Novel Immunotherapy Against Chronic Hepatitis B 2ABIVAX Recruits First Patient in a Pivotal Phase IIb/III Clinical Trial with ABX203, a Novel Immunotherapy Against Chronic Hepatitis B 3ABIVAX Recruits First Patient in a Pivotal Phase IIb/III Clinical Trial with ABX203, a Novel Immunotherapy Against Chronic Hepatitis B 4ABIVAX Recruits First Patient in a Pivotal Phase IIb/III Clinical Trial with ABX203, a Novel Immunotherapy Against Chronic Hepatitis B 5Cummins Standardizes On ANSYS Engineering Simulation Software 2Cummins Standardizes On ANSYS Engineering Simulation Software 3
Slick® Disposable Endotracheal Stylet, Nylon-coated wire, Malleable core, Sureloc Stop helps maintain desired length for patient safety. Handle forming capability for better grip. Sterile. Single...
... spine manipulation. Prevent dental and soft tissue ... alternative to X-ray. Light-guided intubation is based ... in the neck. This technique takes advantage ... relative to the esophagus. A well-defined, circumscribed ...
All endotracheal accessories are designed to ensure your technique. The Blue Line® intubation stylets feature a satin-smooth coating and are available in three sizes....
... of flexible lighting products. The first is ... different sizes 5", 10", and 15" (refers ... light). These lights are for use in ... ,The second group of flexible lights is ...
Medicine Products: