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Phase II study shows HRPC patients with bone metastases see improved survival with ZD4054
Date:9/25/2007

d be an important treatment option for patients with HRPC. In addition, ZD4054 has a manageable side-effect profile, which included headache, oedema and nasal congestion.1

The Phase II EPOC study design: This study recruited a total of 312 asymptomatic or mildly symptomatic HRPC patients with bone metastases who were randomised into one of three treatment arms: 15mg ZD4054 once-daily; 10mg ZD4054 once daily or a placebo tablet once-daily. In addition to study treatment, all men randomised into the study received best supportive care.

Mode of action specific ETA receptor antagonism:

ZD4054 works by specifically blocking the ETA receptor. This may lead to the inhibition of multiple processes that drive tumour growth and spread, including tumour cell proliferation, tumour cell survival, angiogenesis and the formation of bone metastases.2 It does so without blocking the ETB receptor, which may provide beneficial biological effects in terms of encouraging apoptosis, the death of unhealthy cells.

The future of ZD4054:

ZD4054 has shown promising results in this Phase II study in patients with metastatic hormone resistant prostate cancer, said Alex Oldham, ZD4054 Vice President. AstraZeneca is committed to confirming these findings and further evaluating the activity of ZD4054 in HRPC through a comprehensive Phase III clinical development programme.

The three Phase III trials will investigate a 10mg once-daily dose of ZD4054.

AstraZeneca has a well-established prostate cancer franchise based on its leading hormonal treatments ZOLADEX (goserelin), first launched in 1987, and CASODEX (bicalutamide), first launched in 1995.


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Contact: Aoife Gallagher
aoife_gallagher@uk.cohnwolfe.com
44-078-943-86422
Cohn & Wolfe Healthcare, London
Source:Eurekalert

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