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Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent
Date:10/24/2007

f the treatments two-week infusion, ECO-4601 was cleared from the blood relatively quickly. Therefore, there is unlikely to be drug accumulation from cycle to cycle. This is important as the drug is intended to be used chronically and if a drug accumulates, side effects and toxicities may develop, Falardeau said. The anti-tumor activity of ECO-461 is further maximized by continuous infusion, he explains.

The researchers say that of seven patients who completed three cycles of drug treatment in the dose escalation portion of the trial, six demonstrated stable disease, which Falardeau suggests is a preliminary sign of efficacy. These data, together with extensive non-clinical data and the data presented at this conference, support the continued development of ECO-4601 for the treatment of cancer, said Falardeau.


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Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

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