Navigation Links
Phase 3 Trial Initiated to Evaluate Combination Therapy of Nexavar(R) and Tarceva(R) in Patients with Liver Cancer
Date:5/28/2009

(3,4) In 2002, approximately 600,000 people died of liver cancer including approximately 370,000 in China, South Korea and Japan, 57,000 in the European Union, and 13,000 in the United States.(3)

Nexavar's Differentiated Mechanism

Nexavar, an oral anti-cancer therapy, is currently approved in more than 70 countries for liver cancer and in more than 80 countries for the treatment of patients with advanced kidney cancer. Nexavar targets both the tumor cell and tumor vasculature. In preclinical studies, Nexavar has been shown to target members of two classes of kinases known to be involved in both cell proliferation (growth) and angiogenesis (blood supply) - two important processes that enable cancer growth. These kinases included Raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, FLT-3 and RET.

Nexavar, which is co-developed by Bayer Healthcare Pharmaceuticals and Onyx Pharmaceuticals, Inc., is being evaluated by the companies, international study groups, government agencies and individual investigators as a single agent or combination treatment in a wide range of other cancers, including breast cancer, lung cancer, ovarian cancer, colorectal cancer, and as an adjuvant therapy for kidney cancer and liver cancer.

Important Safety Considerations For Patients Taking Nexavar

Based on the currently approved U.S. package insert for the treatment of patients with unresectable hepatocellular carcinoma, hypertension may occur early in the course of therapy and blood pressure should be monitored weekly during the first six weeks of therapy and treated as needed. Bleeding with a fatal outcome from any site was reported in 2.4% for Nexavar and 4% in placebo. The incidence of treatment-emergent cardiac ischemia/infarction was 2.7% for Nexavar vs. 1.3% for placebo. Most common adverse events reported with Nexavar in patients with unresectable HCC were diarrhea, fatigue, abdominal pain, weig
'/>"/>

SOURCE Bayer HealthCare Pharmaceuticals Inc.; OSI Pharmaceuticals; Onyx Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Ceregene Presents Additional Clinical Data from Phase 2 Trial of CERE-120 for Parkinsons Disease
2. The National Association of Boards of Pharmacy (NABP) Moves to Next Phase of Technician Recognition and Regulation
3. MAP Pharmaceuticals Phase 3 Trial of LEVADEX(TM) Migraine Product Candidate Meets All Four Primary Endpoints
4. Bioniche Phase III Clinical Trial with Urocidin(TM) Progressing Well
5. National Medical Interpreter Certification Testing Enters Pilot Phase
6. Results of phase III study on Labopharms novel antidepressant published in Psychiatry (Edgemont) Journal
7. Trubion Pharmaceuticals, Inc. to Present Positive Data From a Phase 2b Re-treatment Study of TRU-015 at the 2009 EULAR Annual Meeting
8. Rexin-G Controls Tumor Growth and Improves Survival in Chemotherapy-Resistant Sarcoma and Osteosarcoma: Phase I/II and Phase II Studies, ASCO 2009
9. InDex Pharmaceuticals AB Engages PharmaVentures to Facilitate the Licensing of Kappaproct(R) After Phase IIa Trial Achieves Clinical Endpoints Early
10. BioVex To Announce Updated Survival Data From a Phase II Clinical Study of OncoVEX GM-CSF in Metastatic Melanoma at The 2009 American Society of Clinical Oncology Meeting
11. Kinovate Life Sciences, Inc. and Nitto Denko Corporation Announce Successful Development of NittoPhase™ HL High Loading Solid Support for Oligonucleotide Synthesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... sweetFrog Enterprises, ... Mississippi. The opening is the first sweetFrog store located in Mississippi. The premium frozen ... companies in 2014. , The store, located at 104 Railroad Avenue, New Albany, MS ...
(Date:7/2/2015)... ... July 02, 2015 , ... The ... her introduction of the Stop Overdose Stat (S.O.S.) Act of 2015 on June ... (D-R.I.), this Act seeks to decrease drug overdose – especially of heroin and ...
(Date:7/2/2015)... ... 02, 2015 , ... In 2012, Patrick Achebe realized that the gift of poetry was fully ... to write his first poem, and three years later he was publishing an entire book ... sharing with the world. "I have always believed that the best way to lift yourself ...
(Date:7/2/2015)... GA (PRWEB) , ... July 02, 2015 , ... Global ... newest innovation in compression socks designed for men. , For style that’s quick ... into their daily routine. This is great news for men everywhere because a simple ...
(Date:7/2/2015)... PLAINSBORO, N.J. (PRWEB) , ... July 02, 2015 ... ... ACO and Emerging Healthcare Delivery Coalition met for the late June Web-based ... moves forward with new reimbursement schemes and managing high-risk patients through coordinated care. ...
Breaking Medicine News(10 mins):Health News:sweetfrog Opens First Location in Mississippi 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3Health News:Patrick Achebe Releases Debut Book, Whispering Waves: Poems for Everyday Grace 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 2Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 4
... is Light at the end of the tunnel for HRT ... allowed HRT for treatment of symptoms of menopause, vouching its ... has said that, this would be a reprieve for women ... reported in 2002, which suggested that HRT could increase the ...
... of the pan into the fire itself, the burning problem, ... directives to disclose levels of trans fats in packaged foods, ... trans fat in french fries.// The tests have put French ... more ( 8 grammes as against earlier 6 grams level)trans ...
... of the much dreaded bird flu has been reported from ... The situation is being closely // monitored and is believed ... Agricultural department. ,More than 15, 000 chickens in ... flu virus had died. In response to the above situation, ...
... is launching a nationwide outreach program to improve the ... a follow-up to the Antihypertensive and Lipid-Lowering Treatment to ... in collaboration with the National High Blood Pressure Education ... study had compared the effectiveness of four classes of ...
... of people who suffer from the Ischemic Heart Disease (IHD) ... from // person to person, depending upon whether it ... heart is affected by this medical condition, and where Western ... ,When patients seek medical care for chest pain, ...
... Kenya by the World Bank for HIV/AIDS education and banking ... has been delayed due to some allegations pertaining to corruption ... the Kenyan government, the SAPA/Mail & Guardian reports (SAPA/Mail & ... Health in February 2005 it had failed to distribute $54 ...
Cached Medicine News:Health News:The Decks Cleared For HRT - Safe for Menopause Symptoms 2Health News:Diuretics More Effective In Controlling High Blood Pressure 2
(Date:7/2/2015)... 2, 2015  New product launches are critical events ... in educating thought leaders about new products, Medical Affairs ... how well a new therapy performs at launch. ... and consulting leader Best Practices, LLC, critical aspects of ... on are early stage thought leader (TL) interaction, successful ...
(Date:7/2/2015)... July 2, 2015 According to a ... (Deep Brain Stimulation, Spinal Cord Stimulation, Transcranial Magnetic Stimulation), Application ... Forecast to 2020", published by MarketsandMarkets, the global Neuromodulation Market ... to reach $6.20 Billion by 2020, at a CAGR of ... 8 4 market data T ...
(Date:7/2/2015)... 2015 Numotion,s Board of Directors and ... Tamas Feitel has joined the Company as Chief ... highly successful 18 year career at GE serving in ... and productivity to result in significant industry leading growth ... Financial Officer for GE Healthcare Global Services, a $5B ...
Breaking Medicine Technology:Medical Affairs Role in Thought Leader Education is Key Success Factor for New Product Launches in the Pharmaceutical Industry 2Neuromodulation Market Worth $6.20 Billion by 2020 2Neuromodulation Market Worth $6.20 Billion by 2020 3Neuromodulation Market Worth $6.20 Billion by 2020 4Numotion Names Tamas Feitel Chief Financial Officer 2
... and counterfeit versions of thirteen key antimalarial medicines were ... Quality Monitoring surveillance program. Set up by the Ghana ... U.S. Pharmacopeial Convention (USP) and the U.S. Agency for ... public and private sectors. It was established in 2008 ...
... Nov. 8, 2010 The discovery of two explosive devices ... the continued risk posed to the aviation networks by terrorism. ... transported on two passenger planes before being seized in Dubai, ... Airbus A320 from Sanaa to Doha. It contained the powerful ...
Cached Medicine Technology:Substandard and Counterfeit Antimalarial Drugs in Ghana Discovered by Cooperative Program of USP, Ghana Food and Drugs Board 2Substandard and Counterfeit Antimalarial Drugs in Ghana Discovered by Cooperative Program of USP, Ghana Food and Drugs Board 3Marken Rapidly Responds to Global Supply Chain Security Measures 2
RayShield Frame Mounted Overhead Lead Acrylic Barriers are offered in a choice of three sizes: 60 cm x 80 cm ( 24" x 32") wide, 60 cm x 50 cm( 24" x 20") wide. Lead acrylic windows of 0.5 mm and 1.0 ...
Thyroid Collars...
Wrap-Around, Full Protection Apron with BACK SUPPORT...
Shoulder Drop-Off Apron...
Medicine Products: