Navigation Links
Phase 3 GATTEX results presented at DDW highlight potential new treatment in short bowel syndrome
Date:5/19/2008

San Diego, California, May 19, 2008 NPS Pharmaceuticals, Inc. (NASDAQ: NPSP) today reported the presentation of Phase 3 data at the annual Digestive Disease Week (DDW) Congress on GATTEX (teduglutide), a novel investigational compound that may reduce dependence upon parenteral nutrition (PN) in patients with intestinal failure associated with short bowel syndrome (SBS).

The Phase 3 study evaluated two doses of GATTEX versus placebo. Results indicate that GATTEX was generally well-tolerated and effective in reducing the PN requirements of SBS patients, with the lower dose findings showing statistical significance versus placebo. The company is finalizing a protocol for a Phase 3 confirmatory study, which it expects will begin in the third quarter of 2008. Stephen OKeefe, M.D., professor of medicine, University of Pittsburgh, presented the Phase 3 results today at an American Gastroenterological Association (AGA) Institute clinical science plenary session.

Data from this study show that GATTEX has the potential to reduce or eliminate the need for parenteral nutrition, thereby reducing the complications associated with PN therapy and improving quality of life for patients with intestinal failure due to surgical resection (SBS), said Dr. OKeefe. These latest findings provide further support for the development of GATTEX as a potential first-in-class compound to reduce the dependency of SBS patients on IV fluids and nutrition without adverse side effects.

The pivotal Phase 3 study evaluated 83 SBS patients who are dependent on PN. After a PN stabilization and optimization period, patients were randomized to receive low-dose of GATTEX (0.05 mg/kg/day), high-dose GATTEX (0.10 mg/kg/day) or placebo for 24 weeks. A clinically significant PN response was defined as a weekly reduction of PN requirements of more than 20% at dosing week 20 and maintained through dosing week 24.

Key findings were as follows:


  • '/>"/>

Contact: Stephen Bingham
609-514-5117
JFK Communcations
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. New AMITIZA 8 mcg phase III studies demonstrated overall symptom improvement in adult women
2. AEterna Zentaris Announces First Patient Dosing for Safety Trial of Phase 3 Program with Cetrorelix in Benign Prostatic Hyperplasia
3. Phase III pivotal results presented of VYVANSE to treat ADHD in adults
4. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
5. NicOx Announces U.S. Phase 2a Results for PF-03187207 and Gives an Update on Continuing NO-prostaglandin Program
6. Phase 3 data Re: Anti-RSV antibody to be presented at Pediatric Academic Societies Annual Meeting
7. Wal-Mart Launches Phase Three of $4 Prescription Program
8. Sanofi-aventis: Encouraging First-Quarter 2008 Results Further Positive Phase III Results for Eplivanserin
9. Antipodean Pharmaceuticals Announces Results of Phase 2 Study of Lead Compound MitoQ(R)
10. Arpida Provides Comprhensive Overview of Pivotal Phase III Trial Data
11. QLT initiates phase II study of punctal plug drug delivery system for glaucoma & ocular hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 2014 Good Neighbor Community Services ... upcoming episode of Innovations with Ed Begley Jr, ... and show times TBA. , In this segment, ... Services’ vision to redefine the traditional approach to ... services. Through passion, innovation, determination, excellence, and collaboration, ...
(Date:7/30/2014)... SF Cable, distributor of the highest quality cables, ... internet with guaranteed customer satisfaction announces the availability of ... These lightning cords are MFI certified to meet Apple ... Cable Lightning to USB Cables feature the ... and syncing. Compatible with the iPhone 5S/5C/5 plus iPad ...
(Date:7/30/2014)... IN (PRWEB) July 30, 2014 ... the opening of its new Carmel office on July ... staff will finally be moving to the state-of-the-art suite, ... cozy and innovative space will allow for one-on-one patient ... cosmetic surgery experience. , Dr. Hamilton’s new office-suite ...
(Date:7/30/2014)... ... ... ... , UCLA researchers interviewed people with diverticulitis and confirmed that many suffer psychological and physical symptoms long after ... a UCLA team led by Dr. Brennan Spiegel interviewed patients in great detail about the symptoms they experience weeks, months or even ...
(Date:7/30/2014)... 2014 As the controversy surrounding the ... surgeries continues to grow, Bernstein Liebhard LLP notes that ... for a ban on uterine morcellation. According to a ... with leiomyosarcoma following a hysterectomy that involved the use ... diagnosis, the aggressive cancer had progressed to Stage 4. ...
Breaking Medicine News(10 mins):Health News:Good Neighbor Community Services to be Featured in an Upcoming Episode of Innovations With Ed Begley, Jr. 2Health News:SF Cable Delivers Certified Lightning Cable in Multiple Sizes and Colors 2Health News:Hamilton Facial Plastic Surgery Opens New Carmel Office 2Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 2Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 3Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 2Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 3Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 4
... Practice Guidelines (CPG) has recommended that waist circumference be ... that a national surveillance system be developed that incorporates ... ,This represents a landmark publication, as Canada is the ... guidelines to address the management and prevention of overweight ...
... body to address issues such as food quality and safety, ... ,"We have been concerned with integration of our food ... agencies, and hence we have recently enacted the Food Safety ... be administered by a single autonomous and scientific regulatory body," ...
... a heat wave with day temperatures in state capital ... shooting// up to 42 degrees Celsius. ,Roads ... Korba. In Raipur, people preferred to remain indoors while ... department has forecast a further rise in heat this ...
... agreed to lower the prices of Kaletra/Aluvia in low ... on a request from the World Health Organization’s Director-General ... the treatment of HIV-1 infected adults and children above ... antiretroviral agents. It is in a category of HIV ...
... obviously stressed. Who wouldn’t be with a daughter like Tracey! ... puffing her way through// a mountain of cigarettes three or ... Hunt, formerly Langton and Rachid) is a long-running character on ... by Anne Kirkbride since 1972. Deirdre has become synonymous with ...
... the Novartis case, the government of India is moving fast ... ,It has now been notified that all patent litigations filed ... amended Patent Act have been transferred to the Intellectual Property ... pharmaceutical companies have filed cases in High Courts and lower ...
Cached Medicine News:Health News:New Guidelines to Address Growing Obesity Epidemic 2Health News:New Guidelines to Address Growing Obesity Epidemic 3Health News:Abbott to Subsidize Price of HIV Drug 2Health News:Smoking on Television is Harmful to the Health of the Nation's Youth: BMA 2Health News:Smoking on Television is Harmful to the Health of the Nation's Youth: BMA 3Health News:Patents: Appellate Board Becomes Functional 2
(Date:7/30/2014)... July 30, 2014 The Board of ... (AMCP) last evening expressed support for the "Pharmacists, ... Commission of Pharmacy Practitioners (JCPP).  As a JCPP ... a two-year period to develop a scalable, viable ... "Pharmacists are fast becoming one of ...
(Date:7/30/2014)... and Markets has announced the addition of the "Hematology ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 The ... in developed countries; however, it is expected to witness high growth ... India , and Brazil in ... analyzers and reagents market is driven by factors such as increasing ...
(Date:7/30/2014)... , July 30, 2014 /PRNewswire-iReach/ -- Transluminal Technologies ... medical device company, has announced today that they ... CD™ Vascular Closure Device. Velox CD™ provides a ... following percutaneous femoral procedures. The single size velox ... in size from 5F to 8F.  ...
Breaking Medicine Technology:AMCP Endorses JCPP "Pharmacists' Patient Care Process" 2Hematology Analyzers & Reagents Market - Forecasts to 2019 2Transluminal Technologies receives CE Mark approval for velox CD(TM) vascular closure device 2
... July 29 IRIDEX Corporation (Nasdaq: IRIX ) today ... Trademark Office for U.S. Patent No. 7,766,904, "Adjustable Laser Probe For Use ... devices already in the IRIDEX product line, collectively identified and sold as ... , , ...
... For All® Inc., MMM Healthcare, Inc. (MMM) and ... access to medications, lab testing and medical imaging at substantial rate reductions ... , , ... that entitles users to savings that range as high as 50 to ...
Cached Medicine Technology:IRIDEX Granted U.S. Patent for Adjustable Laser Probe for Eye Surgery 2IRIDEX Granted U.S. Patent for Adjustable Laser Probe for Eye Surgery 3Free For All® Inc., MMM and PMC Assist Members with Pharmacy Discount 2Free For All® Inc., MMM and PMC Assist Members with Pharmacy Discount 3Free For All® Inc., MMM and PMC Assist Members with Pharmacy Discount 4
... a fully automated clinical chemistry analyzer. ... assay test parameters with a view ... 60 is an integrated system for ... special chemistries including specific proteins, TDM, ...
... Slide Rack works hand in hand with ... organized, reliable method for immunostaining. The Sequenza ... which ensures consistency and excellent staining quality. ... runs (up to 50 slides/run) with a ...
Inquire...
ISI Micro Brushes are available in a variety of French diameters. Made with stainless steel handles and nylon bristles, the ISI Micro Brushes will last through countless cleanings....
Medicine Products: