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Phase 2 Results of Rigel's R788 Show Clinical Benefit in Diffuse Large B-Cell Lymphoma and CLL
Date:12/7/2008

round 50%. Even for those who respond to treatment, recurrence of the disease is common.

A growing field of research on the cellular signaling associated with these lymphomas indicates that inhibiting Syk (spleen tyrosine kinase) in aberrant cells may control spread of the disease. Two additional research studies on the topic are also being presented at the ASH meeting. They are: Abstract 377, entitled "BCR, Signaling Diversity in Human Lymphoma B Cells Correlates with Follicular Lymphoma Patient Clinical Outcomes" and Abstract 802, entitled "BCL-6 Regulates Tonic BCR Signaling in Diffuse Large B-Cell Lymphomas." Further information on R788 in B-cell lymphoma is available at Rigel's website: http://www.rigel.com/rigel/lymphoma.

Conference Call and Webcast Information

To access the live call, please dial 800-561-2693 (domestic) or 617-614-3523 (international) 10 minutes prior to the start time and use the passcode 36883961. A replay of the call will be available, in webcast and podcast formats, at approximately 6:00 p.m. PST on December 7, 2008 through December 14, 2008. To access the replay, please dial 888-286-8010 (domestic) or 617-801-6888 (international) and use the passcode 47095093. The conference call will also be webcast live and can be accessed from Rigel's website at http://www.rigel.com. Please connect to Rigel's website several minutes prior to the start of the live webcast to ensure adequate time for any software downloads that may be necessary.

About Rigel (http://www.Rigel.com)

Rigel is a clinical-stage drug development company that discovers and develops novel, small-molecule drugs for the treatment of inflammatory/autoimmune diseases and cancer, as well as viral and metabolic diseases. Our pion
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