Navigation Links
Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development
Date:7/7/2009

PRINCETON, N.J., July 7 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS) announced today the nomination of PSI-352938 ("PSI-938") as a lead development candidate from two series of purine analogs for the treatment of chronic hepatitis C virus (HCV) infection. PSI-938 is a proprietary nucleotide analog polymerase inhibitor of HCV that is being advanced into studies required for submission of an Investigational New Drug (IND) application with the FDA or equivalent foreign regulatory application.

"PSI-938 is particularly interesting to us since it differs from our pyrimidine analogs, R7128 and PSI-7851, because it has a complementary resistance profile and is metabolized through a different phosphorylation pathway," stated Michael Otto, PhD, Pharmasset's Chief Scientific Officer. "These differences may prove to be particularly important as we explore combinations of nucleos(t)ides in clinical development in the future."

Purine nucleos(t)ide analogs have many of the benefits of pyrimidine nucleos(t)ide analogs, like R7128 and PSI-7851, in that they have demonstrated in vitro activity across multiple genotypes, a higher barrier to resistance than other classes of HCV small molecules in development, and the potential to be combined with other direct acting antivirals targeting HCV. In addition, these purine analogs are also active against the S282T resistant variant selected in vitro by the pyrimidine analogs, and are metabolized to the active triphosphate form through a different phosphorylation pathway than the pyrimidines. Given these characteristics, purine and pyrimidine analogs have the potential to be combined as part of a future treatment regimen.

About Pharmasset

Pharmasset is a clinical-stage pharmaceutical company committed to discovering, developing, and commercializing
'/>"/>

SOURCE Pharmasset, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients
2. Pharmasset to Present at Deutsche Bank Healthcare Conference
3. Pharmasset to Present at Two Upcoming Investor Conferences
4. Pharmasset to Present at Two Upcoming Investor Conferences
5. Pharmasset to Present at the 27th Annual JPMorgan Healthcare Conference
6. Pharmasset to Webcast an Investor Event from the AASLD Meeting
7. Pharmasset Reports Financial Results for Quarter Ended March 31, 2008
8. Pharmasset to Present at the Rodman & Renshaw Healthcare Conference on Tuesday, May 20th
9. Pharmasset Appoints Patrick T. Higgins as Executive Vice President, Marketing & Sales
10. Pharmasset Presents R7128 14-Day Monotherapy Study Results for the Treatment of Chronic Hepatitis C
11. Pharmassets Underwriters Release Shares from Lock-Up
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... NC (PRWEB) October 25, 2014 Mesothelioma ... who continued to receive pemetrexed (Alimta), after his combination ... read the full story , just posted on the ... from Uji Tokushukai Medical Center in Japan suggests that ... mesothelioma patients who cannot tolerate higher doses ...
(Date:10/25/2014)... Steven Reinberg HealthDay Reporter ... causes common cold sores -- herpes simplex -- might increase ... suggest. In fact, being a carrier of certain antibodies ... the researchers found. "The identification of a treatable ... a breakthrough," said lead researcher Dr. Hugo Lovheim, an associate ...
(Date:10/25/2014)... THURSDAY, Oct. 23, 2014 (HealthDay News) -- A large ... West Africa is to avoid tens of thousands of ... Yale University researchers predict. Using a specially ... future of the outbreak in just one densely populated ... the capital city of Monrovia. The researchers said ...
(Date:10/25/2014)... -- October,s shorter, darker days can trigger a type ... an expert. People affected by seasonal affective ... motivation and even have trouble getting out of bed. ... Dr. Angelos Halaris, a professor in the department of ... School of Medicine. "Seasonal affective disorder should not ...
(Date:10/22/2014)... 22, 2014 On October 22, CBS ... featuring skin diseases both fictional and real. The ... nonprofit organization committed to advocacy and philanthropy in the ... take the opportunity to impart truth and clarity about ... There are many misconceptions about Morgellons Disease ...
Breaking Medicine News(10 mins):Health News:New Report Illustrates Extended Mesothelioma Survival with “Maintenance Therapy”, According to Surviving Mesothelioma 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 3Health News:Experts Predict 'Catastrophic' Ebola Epidemic in West Africa if Aid Delayed 2Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3
... -- Patients who undergo angioplasty to unblock a clogged ... in a cardiac rehabilitation program afterwards, researchers report. ... are significant given the fact that more than 600,000 ... according to the American Heart Association (AHA). In ...
... Randy Dotinga HealthDay Reporter , MONDAY, May 16 (HealthDay ... infested by parasites despite clinical evidence to the contrary. Now, ... in the patient,s head -- is often right on target. ... bugs, worms or germs had invaded their skin. In all but ...
... broadly support a strong commitment to medical and health ... and the state,s and the nation,s economy, according to ... Research!America and Northeast Ohio Medical University (NEOMED). ... health research is important42% say very importantto the state,s ...
... By Steven Reinberg HealthDay Reporter , MONDAY, ... control attention deficit hyperactivity disorder appear to be at ... taking ADHD medications, a new study finds. "ADHD ... might be expected to increase the risk of cardiovascular ...
... and Medicine announce Health System Reform in ... which focuses on the health system reforms Asian ... rapid economic, social, demographic and epidemiologic change in ... social science scholars, policymakers and professionals working in ...
... , MONDAY, May 16 (HealthDay News) -- The ... United States is strongly associated with a local area,s ... facilities provide end-of-life care that can improve pain control, ... lead author Dr. Maria Silveira, of the Veterans Affairs ...
Cached Medicine News:Health News:Cardiac Rehab Can Boost Survival After Angioplasty, Study Finds 2Health News:For Some, Bugs Crawling on Skin Is a Delusion 2Health News:Ohio residents: Medical and health research important to state's economy, jobs and incomes 2Health News:Ohio residents: Medical and health research important to state's economy, jobs and incomes 3Health News:Kids Taking ADHD Drugs at Low Risk for Heart Problems: Study 2Health News:Kids Taking ADHD Drugs at Low Risk for Heart Problems: Study 3Health News:Elsevier Health System Reform in Asia Conference 2Health News:Hospice Care More Common in Wealthier Areas, Study Finds 2
(Date:10/25/2014)... 24, 2014 ... announced the addition of the  "Global and ...  report to their offering.       ... Acne Medication Industry Report 2014 is a ... state of the global acne medication industry ...
(Date:10/25/2014)... 24, 2014 Best Practices designed the ... with a forum for sharing insights about the ... a mechanism for creating and sharing solutions through ... findings from the Medical Affairs Consortium survey. ... for the first roundtable of the 2014-2015 Medical ...
(Date:10/22/2014)... 22, 2014  Medical Diagnostic Laboratories, L.L.C., ... in high complexity, state-of-the-art, automated DNA-based molecular ... new Cystic Fibrosis Testing which utilizes cutting ... platforms. Cystic fibrosis (CF), or ... that affects the respiratory, gastrointestinal and reproductive ...
Breaking Medicine Technology:Global and Chinese Acne Medication Industry Report 2014 2Global and Chinese Acne Medication Industry Report 2014 3Strong Participation in Best Practices' Medical Affairs Consortium Survey 2Medical Diagnostic Laboratories, L.L.C. Institute for Biomarker Research Announces New Prenatal Cystic Fibrosis Tests 2
... Merit Medical Systems, Inc. (NASDAQ: MMSI ... medical devices used in interventional and diagnostic procedures, particularly ... Company will release its financial results for the third ... the stock market on Tuesday, October 25th, 2011. ...
... Md., Oct. 11, 2011 Christine K. Pierre, president ... "Professional Woman of the Year" by the National Association ... Pierre,s "outstanding leadership and commitment" within her profession, according ... Pierre founded RxTrials, Inc., in 1994, and ...
Cached Medicine Technology:Christine Pierre Selected as "Professional Woman of the Year" 2
... MediCopia is a system for inpatient caregiving ... automated computer system offers four technologies in ... a handheld computer (for work order processing), ... thermal printer (for label generation at bedside) ...
The Metrologic MS9520 Voyager is a high performance single line laser bar code scanner with automatic activation and sophisticated data transmission via Metrologic proprietary CodeGate technology....
... wristband that provides automated ID verification for ... efficiency and accuracy. Meets healthcare patient ID ... risk of data left on ribbons (HIPAA) ... (FDA). Also available with UV varnish, which ...
... Laser Sheeted Wristband / ... laser-printable sheets with an ... laser labels that adhere ... clear, fold-over protective window ...
Medicine Products: