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Pharmacyclics Reports Third Quarter 2008 Financial Results
Date:4/24/2008

PCI-24781, by initiating a Phase 1/2 trial evaluating it in hematologic malignancies, and filing investigational new drug applications for our Factor VIIa inhibitor and our Btk inhibitor," said Richard A. Miller, M.D., president and chief executive officer of Pharmacyclics. "We own worldwide rights to these novel compounds, which have the potential to address unmet needs in large patient populations."

Recent Events and Upcoming Milestones

-- Data was published in the February 7 issue of Leukemia characterizing

the company's novel highly-selective histone deacetylase (HDAC)

inhibitor showing that the drug candidate, PCI-34501, inhibits HDAC-8

with 200-1000 fold selectivity over other HDAC enzymes.

-- Six presentations relating to the company's HDAC, Factor VIIa and Btk

programs were made at the American Association for Cancer Research

(AACR) 2008 Annual Meeting held in April 2008:

- Reseachers from the University of Texas M.D. Anderson Cancer

Center conducted laboratory studies with the company's HDAC

inhibitor, PCI-24781, demonstrating inhibition of NFkB, a

transcription factor known to drive tumor growth;

- Other researchers at M.D. Anderson found that treatment of animals

with resistant tumors that overexpress the protein ErbB2, or

Her2, with PCI-24781 led to control of tumors in 80 percent of the

animals, with most achieving partial response;

- The company's Factor VIIa inhibitor, PCI-27483, led to inhibition

of tumor growth in animal models of human pancreatic tumors; and

- PCI-32765, the company's orally available, selective inhibitor of

Bruton's tyrosine kinase, or Btk, was shown to block B-cell

receptor mediated signaling in vitro in the treatment of B-cell

lymphomas. Treatment with PCI-32765 in lymphom
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SOURCE Pharmacyclics, Inc.
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