Navigation Links
Pharmacyclics, Inc. Reports Interim Safety and Clinical Data from a Phase I/II Clinical Trial of its Oral HDAC Inhibitor PCI-24781 in Lymphoma at the American Society of Hematology Annual Meeting
Date:12/6/2009

NEW ORLEANS and SUNNYVALE, Calif., Dec. 6 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC) today announced interim results from a Phase I/II study showing safety and clinical activity in patients with relapsed / recurrent non-Hodgkin's Lymphoma (NHL) treated with its HDAC inhibitor PCI-24781 as a single agent. The data were presented today at the 51st ASH Annual Meeting being held in New Orleans, LA (Abstract # 2726).

PCI-24781 is an oral pan-HDAC inhibitor which is currently in multiple clinical trials for solid and hematological malignancies (PCYC-0401 single center, solid tumor cancer patients IV administered drug; PCYC-0402 multi-center, solid cancer patients orally administered; PCYC-0403 multicenter, lymphoma cancer patients orally administered). This compound, which has been optimized for the best combination of potency and pharmacokinetics (PK), has potent anti-tumor activity in a variety of preclinical tumor models (Buggy et al Mol Cancer Ther 5:1309-1317, 2006) and has also demonstrated safety and clinical benefit in human solid tumors (Undevia et al, ASCO 2008).

In a review of the clinical data at the end of the Phase I dose-escalation portion of the current lymphoma trial, it was revealed that PCI-24781 has shown strong signs of efficacy with minimal toxicity as a single agent in lymphoma, with 1 Complete Response (follicular lymphoma), 4 Partial Responses (2 follicular lymphoma, 1 diffuse large B-cell lymphoma, 1 mantle cell lymphoma) and 6 Stable Disease in 16 patients evaluated for response (after 2 cycles). Partial Response is defined as a 50% reduction in tumor size. The Overall Response Rate (Partial and Complete Response) has been 31%, with responses being observed in each of the four cohorts. Of 4 follicular lymphoma patients evaluated in this trial, 3 had objective response
'/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3 4 5

Related medicine news :

1. PD-Rx Pharmaceuticals, Inc. Reports 1st Quarter Earnings
2. New American Meditation Institute Study Reports Wide-Ranging Health Benefits from Meditation and Yoga
3. China Nepstar Chain Drugstore Reports 92.1% Year-on-Year Increase in Operating Income for Third Quarter 2009
4. CRH Medical reports Q3 2009 results
5. ICL Reports Continued Sequential Improvement for Third Quarter of 2009
6. SIRIUS XM to Broadcast Doctor Radio Reports: What Every Woman Needs To Know About Mammograms
7. Lifeway Foods Reports Record 3rd Quarter 2009 Revenues and Earnings Results
8. China Medical Technologies Reports Second Fiscal Quarter Financial Results
9. Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter
10. Coal Pollution Damages Human Health at Every Stage of Coal Life Cycle, Reports Physicians for Social Responsibility
11. AdCare Health Systems, Inc. Reports 2009 Third Quarter Earnings Results; Third Consecutive Profitable Quarter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... URBANA What effect does a father,s depression have on ... level of emotional intimacy in their marriage, their children benefit, ... is interacting with their child, they need to be able ... to his developmental stage and abilities, and notice whether he ... difficulty doing that," said Nancy McElwain, a U of I ...
(Date:5/22/2013)... IL A new study suggests that disturbed ... of depression and greater uncertainly about future success. ... and teachers appears to have a protective effect. ... significantly associated with depressed mood and greater uncertainty ... from parents and from teachers were associated with ...
(Date:5/22/2013)... drugs to the "power plants" that make energy to ... to preventing emergence of the drug-resistant forms of cancer ... reporting. That,s the conclusion of a new study published ... , Shana Kelley and colleagues explain that doxorubicin and ... genes inside the nucleus of cancer cells. Cancer cells ...
(Date:5/22/2013)... The newest member of TeethWhiteningforFree.com is Dr. ... Alabama graduate, Dr. Sanderson provides professional dental care to ... he extends complimentary teeth whitening to his patients who ... up. Only a dental professional can decide if the ... , Teeth whitening is an easy way ...
(Date:5/22/2013)... Slip and fall hazards are a common ... factors. A December 2010 CDC (Centers for Disease Control ... most common: contaminants on the floor, poor drainage problems, ... and lack of handrails (i). Common injuries resulting from ... muscles, fractures, broken bones, spinal cord injuries , ...
Breaking Medicine News(10 mins):Health News:Good marriage can buffer effects of dad's depression on young children 2Health News:Parent and teacher support protects teens from sleep problems and depression 2Health News:Dr. James Sanderson, Jr. Of SanDentistry in Hoover, Alabama Joins the TeethWhiteningforFree.com Family 2Health News:Law Firm Releases Slip and Fall Accident Informational Graphic to Show the Frequency and Cost of These Incidents 2Health News:Law Firm Releases Slip and Fall Accident Informational Graphic to Show the Frequency and Cost of These Incidents 3
... ... logo and a brand new website. A new focus on internet marketing will expand ... ... announces its new branding and marketing campaign launched in April 2010. The campaign incorporates a ...
... ... port technique for gynaecological procedures, raising the bar for minimally invasive surgery. , ... Singapore (Vocus) May 12, ... invasive surgery to new heights with the introduction of a specially designed port ...
... ... for marketing to both professionals and consumers. , ... (Vocus) May 11, 2010 -- SDI , a ... away from print advertising toward electronic promotion — for marketing to both professionals and ...
... infectious diseases cause two-thirds of child deaths, according to ... . Experts from the World Health Organization (WHO) and ... from 193 countries to produce estimates by country, region ... declined globally over the last decade, the analysis reveals ...
... to infectious diseases, researchers report , TUESDAY, May 11 ... malaria and blood poisoning account for more than two-thirds ... 5 years of age worldwide, a new report shows. ... birth complications, lack of oxygen during birth and congenital ...
... affect brain function in adults who have few or ... results of the first study to examine cognitive functioning ... funded by the National Heart, Lung, and Blood Institute ... brain function scores and imaging tests in adult patients ...
Cached Medicine News:Health News:MedCorp LLC Unveils New Marketing Campaign Including Refreshed Logo and All-New Website Focused on Ultrasound 2Health News:Singapore's Gynaecologists Break New Grounds 2Health News:Singapore's Gynaecologists Break New Grounds 3Health News:Singapore's Gynaecologists Break New Grounds 4Health News:SDI Reports: Pharmaceutical Promotion Spending Indicates Trend Toward Electronic and Online Promotion 2Health News:Infectious diseases caused two-thirds of the nearly 9 million child deaths globally in 2008 2Health News:Almost Half of Deaths in Kids Under 5 Occur in 5 Countries 2Health News:New study suggests sickle cell disease may affect brain function in adults 2Health News:New study suggests sickle cell disease may affect brain function in adults 3
(Date:5/22/2013)... 22, 2013 Pomerantz Grossman Hufford ... on behalf of investors of Intuitive Surgical, Inc. ("Intuitive ... (CUSIP: 46120E602) who purchased Intuitive Surgical common stock between ... Period"). Such investors are advised to contact ... or 888-476-6529, ext. 237. The investigation concerns ...
(Date:5/22/2013)... ORLEANS , May 22, 2013 ... for commercially-insured patients with Type 2 diabetes, while ... to improve health outcomes and can lead to ... presented at the International Society for Pharmacoeconomics and ... The two studies, sponsored by Valeritas, makers ...
(Date:5/22/2013)... TOKYO , May 22, 2013 ... Daiichi Sankyo Co., Ltd. (hereafter, Daiichi Sankyo), announced ... taken in recent years to address past conduct ... ). Daiichi Sankyo continues to ... correct the conduct of the past which led ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Intuitive Surgical, Inc. - ISRG 2Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 2Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 3Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 4Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 5Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 6
... Misonix, Inc. (NASDAQ: MSON ), ... markets innovative therapeutic ultrasonic products worldwide for wound ... and other surgical and medical applications, has announced ... Cutting System at the International Meeting on Advanced ...
... -- China Botanic Pharmaceutical Inc. (NYSE AMEX: ... manufacturer and distributor of botanical products, bio-pharmaceuticals and traditional ... Company has recently hosted a technical exchange between 13 ... Medicine (TCM) and herbal medicine. China ...
Cached Medicine Technology:Misonix Exhibits BoneScalpel™ at the International Meeting on Advanced Spine Techniques 2Misonix Exhibits BoneScalpel™ at the International Meeting on Advanced Spine Techniques 3China Botanic Hosts Technical Exchange for Industry Research Experts 2China Botanic Hosts Technical Exchange for Industry Research Experts 3
... Oximeter with SAC (Serial Autocorrelation) Technology uses ... extract SpO 2 , pulse strength, and ... This cost-effective compact monitor incorporates clinical, ... features, and a data log or trend ...
... Autocorr Plus, the fourth in the ... pulse oximeter/ECG/Respiration Monitor, with 3 or ... oximetry with SAC (Serial Autocorrelation) technology, ... screen display provides two user configurable ...
... The BCI 3180 Pulse Oximeter is a ... SpO 2 pulse rate and pulse ... adult. This AC or battery powered ... low alarm limits and up to 30 ...
... ReZoom intraocular lens is a second-generation refractive ... with greater independence from glasses than monofocal ... a range of vision that monfocals cannot ... technology distributes light over five optic zones ...
Medicine Products: