Navigation Links
Pharmacy researcher finds most popular weight-loss drug strongly alters other drug therapies
Date:12/10/2012

KINGSTON, R.I. December 10, 2012 A University of Rhode Island researcher has discovered that the weight-loss drug orlistat, known by the brand names Xenical and Alli, inhibits a key enzyme that may lead to "severe toxicity of internal organs such as the liver and kidney." The inhibition is irreversible and can be caused by a low level of the drug.

Professor Bingfang Yan's study funded by the National Institutes of Health, also found that the drug alters efficacy of medicines, and particularly limits the effectiveness of some anti-cancer drugs.

Part of the research results will be published in the journal, Biochemical Pharmacology, which has the article posted on its website today. Yan also alerted the U.S. Food and Drug Administration to his findings.

Orlistat, which was originally approved by the FDA in 1999 as the prescription drug Exenical, was approved in 2007 as the over-the-counter medication Alli. It has been the most commonly used medicine to treat obesity for more than a decade, Yan said.

"Since it has been available overthe-counter, there has been a drastic increase of toxicity among patients using the drug," Yan said. "It has been linked to severe liver failure, acute pancreatic failure and acute renal (kidney) failure."

Yan said orlistat works in the intestinal tract by preventing fat from being absorbed by the body. It is generally accepted that orlistat remains in the intestine and that the body does not absorb it.

"But orlistat is reportedly absorbed, and certainly internal organs such as the liver and kidney are exposed to this drug upon absorption," he said.

The study showed that the drug is a potent inhibitor of carboxylesterase-2, which is a major detoxification enzyme in the liver, kidney and gastrointestinal track. "When the activity of this enzyme drop in those organs, toxicity increases or the efficacy of some drugs are altered," Yan said.

The enzyme is known t
'/>"/>

Contact: Dave Lavallee
dlavallee@advance.uri.edu
401-874-5862
University of Rhode Island
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Women’s Excellence in Bladder Control Partners with University Compounding Pharmacy in Troy, MI to Help Women with Chronic Pelvic Pain Conditions
2. Owner of Meningitis-Linked Pharmacy Declines to Testify Before Congress
3. Company With Ties to Meningitis-Linked Pharmacy Recalls All Products
4. Company With Links to Meningitis-Linked Pharmacy Recalls All Products
5. Second Compounding Pharmacy Shut Down in Massachusetts
6. A Void In The Independent Pharmacy Industry Leads to Independent Rx Consulting, Powered by OurHelix
7. Pharmacy Robots Linked to Bacterial Contamination of Drugs
8. Boston College researcher looks to stop a deadly parasite in its tracks
9. Researchers develop novel 3-D culture system for inflammatory breast cancer
10. Speech-language researcher awarded top honors
11. Researchers craft tool to minimize threat of endocrine disruptors in new chemicals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... ... Renowned rhinoplasty surgeon and Symposium Chairman, Dr. Rod J. Rohrich ... for March 6th - 8th, the 2016 meeting will be held at the Westin ... of nasal surgery through the most modern advancements and updates in rhinoplasty and ...
(Date:7/1/2015)... , ... July 01, 2015 , ... Summer recess has ... teenagers to fix noses and chins with plastic surgery when they’re looking for a ... more than 236,000 cosmetic procedures were performed on patients ages 19 and younger in ...
(Date:7/1/2015)... ... 2015 , ... Did you know that infertility in men is more common ... Advanced Fertility Center of Texas (AFCT) would like to talk about some natural ways ... considered to be a “woman’s issue,” male fertility factors can play a role in ...
(Date:7/1/2015)... ... (PRWEB) July 01, 2015 , ... Lisa Keys, the widow of U.S. Army ... (MSG Keys’ birthday) in memory of her late husband and all of America’s fallen ... the Bronze Star Medal, died during a Special Forces training exercise in December of ...
(Date:7/1/2015)... ... July 01, 2015 , ... Convoy of Hope will partner with ... Cities on Saturday, August 1, at Spring Lake Park High School. , During the ... $1 million worth of goods and services including free food, health services, family portraits, ...
Breaking Medicine News(10 mins):Health News:Dr. Rod J. Rohrich Announces Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces Dates for 2016 Dallas Rhinoplasty Symposium 3Health News:Top Manhattan Facial Plastic Surgeon Dr. Sam Rizk Comments on Teen Surgery Trends 2Health News:Top Manhattan Facial Plastic Surgeon Dr. Sam Rizk Comments on Teen Surgery Trends 3Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 2Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 3Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 4Health News:Wife of Fallen Special Forces Soldier to Host Nationwide ‘Virtual 5K’ for Charity 2Health News:Wife of Fallen Special Forces Soldier to Host Nationwide ‘Virtual 5K’ for Charity 3Health News:Convoy of Hope Hosts Community Event in the Twin Cities 2
... tomato, I say tomahto and to most of us it ... language of medicine getting it right is vital. // ... medical terminology textbook was launched on December 6 and aims ... Walker and Jenny Nicol, from QUT's School of Public Health, ...
... to forego considerations of quality education for more practical ... as meals. // ,The findings are from a ... at the University of North Carolina at Chapel Hill, ... pre-kindergarten (pre-K) programs define quality and select programs. The ...
... Ron Matsusaki, a doctor from Canada, rare pediatric cancers have ... western tip of Canada's Prince Edward Island. According to his ... a toxic waste site. The farming community is known ... is used for potato farming (19 sprays) in a single ...
... (NHS) has been jailed for 18 months on charges of ... number of women patients who went in for smear tests. ... ,Thapar, of Cockfosters, north London regularly asked ... had received smear tests. The practice received extra money from ...
... 12 years old- are as capable as teen-agers in ... prefer them as it is more comfortable during activities ... prescribe contact lenses to children until they are at ... professor of optometry at Ohio State University. “But we ...
... a two-day conference on AIDS in Lahore to ... combating the disease. ,The Parliamentarians for Global ... in collaboration with the provincial assembly of Punjab ... is organising the conference on HIV/AIDS and the ...
Cached Medicine News:Health News:Medical Text Takes on an Aussie Style 2Health News:Families Need More Than Quality Education from Pre-K Programs 2Health News:Contact Lenses For Younger Children Also 2Health News:Contact Lenses For Younger Children Also 3
(Date:7/1/2015)... INDIANAPOLIS , July 1, 2015 Eli Lilly ... results for the second quarter of 2015 on Thursday, July ... that day with the investment community and media to further ... will begin at 9 a.m. EDT. Investors, media and the ... call through a link that will be posted on Lilly,s ...
(Date:7/1/2015)... , July 1, 2015 Precyse, a ... education, announced today that, as part of its long ... agreement to be acquired by investment firm Pamplona Capital ... equity investors, Altaris Capital Partners and NewSpring Capital, have ... 1999, has assisted nearly 5,000 healthcare facilities and systems ...
(Date:7/1/2015)... According to a new market research report ... Synthetic, Fibrin, Collagen, Gelatin, Cyanoacrylate, Polymeric, Polyurethane), by Application ... 2020", published by MarketsandMarkets, the global Surgical Sealants and ... 2020, growing at a CAGR of 9.2% during the ... 119 market T ables and 29 ...
Breaking Medicine Technology:Lilly Confirms Date and Conference Call for Second-Quarter 2015 Financial Results Announcement 2Precyse Enters into Acquisition Agreement with Pamplona Capital Management 2Precyse Enters into Acquisition Agreement with Pamplona Capital Management 3Surgical Sealants and Adhesives Market Worth $2.64 Billion by 2020 2Surgical Sealants and Adhesives Market Worth $2.64 Billion by 2020 3Surgical Sealants and Adhesives Market Worth $2.64 Billion by 2020 4
CCR Medical conventional laryngoscopes....
CCR Medical conventional laryngoscopes....
CCR Medical conventional laryngoscopes....
... The Original LMA™ Airway., ,Launched ... and its use is now standard practice ... of patients worldwide the LMA Classic™ is ... intubation. , ,The LMA Classic™ can ...
Medicine Products: