Navigation Links
Pharmaceutical market fails pregnant women; and more
Date:1/21/2008

Anti-tumor activity of rapamycin in glioblastoma

In a clinical trial published this week in PLoS Medicine, Charles Sawyers and colleagues looked at the safety of a drug called rapamycin in a selected group of patients who were undergoingsurgery after recurrence of glioblastoma (a highly malignant tumor of the brain).

In a related research in translation article about the implications of the research, Robert J. Weil, who was not involved in the trial, suggests that the study points the way toward rational design of therapy for stratified groups of patients who share common molecular features and a future that allows cancer researchers and clinicians to reach toward the holy grail of individualized therapy

Citation: Cloughesy TF, Yoshimoto K, Nghiemphu P, Brown K, Dang J, et al. (2008) Antitumor activity of rapamycin in patients with recurrent PTEN-deficient glioblastoma. PLoS Med 5(1): e8

IN YOUR COVERAGE, PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050008

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-01-sawyers.pdf

CONTACT:

Charles Sawyers
Memorial Sloan-Kettering Cancer Center
Chairman, Human Oncology and Pathogenesis Program
New York, NY 10021
United States of America
+1 646 888 2594
+1-646-888-2164 (fax)
sawyersc@mskcc.org

Related PLoS Medicine research in translation article:

Citation: Weil RJ (2008) Incorporating molecular tools into early-stage clinical trials. PLoS Med 5(1): e21.

IN YOUR COVERAGE, PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050021

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-01-weil.pdf

CONTACT:

Robert J. Weil
Cleveland Clinic Foundation
Taussig Cancer Center
Cleveland, Ohio 44195
United States of America
+1 216-444-2007
+1 216-444-2682 (fax)
weilr@ccf.org


FROM THE PLoS MEDICINE MAGAZINE SECTION:

How the pharmaceutical market is failing pregnant women

The existing research and development and business model of the pharmaceutical industry is failing pregnant women, according a policy paper published this week in PLoS Medicine. In their analysis of an industry database that tracks drugs under development since 1981, Imperial College Londons Nick Fisk (Professor of Fetal Medicine, Faculty of Medicine) and Rifat, Atun (Professor of International Health Management, Tanaka Business School) show that pregnancy has become a virtual pharma-free zone with only seventeen drugs under active development for maternal health indications and only one new class of drug licensed in the last 20 years.

For their analysis, the authors searched the Pharmaprojects database, which lists all drugs identified as being under development from pharmaceutical company web sites, conferences, PubMed (a searchable database of the abstracts of published medical journal articles) and registered clinical trials. Over 37,000 drugs under development have been listed since 1981. They searched for drugs for obstetric applications and, in order to compare industry activity in maternal health relative to other areas of medicine, they also examined the database for drugs for cardiovascular indications and for a rare condition called amyotrophic lateral sclerosis - a neurodegenerative disease sometimes called Lou Gehrigs disease.

The team found only seventeen drugs under active development for maternal indications as of November 2007, less than 3% of the number in the pipeline in cardiovascular health (660 drugs) and less than those for amyotrophic lateral sclerosis (34 drugs), which only affects two to five of 100,000 people. In contrast, worldwide there are over half a million maternal deaths annually while over 7 million babies die before or shortly after birth, 99% of these in the developing world.

The authors argue that their study demonstrates a drug drought in maternal health. They outline how the push mechanisms (funding to encourage investment from universities and companies) and pull mechanisms (funding to purchase drugs once they are on the market) relevant to the United Nations Millennium Development Goal of providing affordable essential drugs in developing countries have not been effective in the area of maternal health.

One of the reasons that pharmaceutical companies are reluctant to test and develop drugs in pregnancy, say the authors, is to avoid the litigation costs that come with the risk of birth defects and disfigurements, despite the fact that these risks are of little relevance to drug development for conditions in later pregnancy. Other reasons for market failure cited by the authors are the small market size for conditions affecting pregnant women, the limitations of a shareholder model (maternal health drugs have a greater potential for revenue shocks) and a regulatory system that allows endemic off-label use of drugs in pregnancy, discouraging pharmaceutical investment in the long term.

In contrast, the authors point towards models such as the Drugs for Neglected Diseases Initiative (DNDI) as an example of a successful push mechanism that encourages investment and they suggest that not-for profit options which do not rely on profit for innovation should be considered. They conclude that between the pull and the push, the international donor agencies have also forgotten these women. Given the unacceptably high number of maternal and perinatal deaths each year, it is high time to address this failure.

Citation: Fisk NM, Atun R (2008) Market failure and the poverty of new drugs in maternal health. PLoS Med 5(1): e22.

IN YOUR COVERAGE, PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050022

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-01-fisk.pdf

CONTACTS:

Elliott White
Press and PR Manager
Imperial College London
London
United Kingdom
+44 20 7594 9154
e.white@imperial.ac.uk

Marlene McKendry
Communications Officer
University of Queensland
Brisbane
Australia
+61 7 3346 4713
m.mckendry@uq.edu.au


'/>"/>

Contact: Josh Eveleth
jeveleth@plos.org
415-624-1234
Public Library of Science
Source:Eurekalert

Related medicine news :

1. Mylan Commences Tender Offers and Consent Solicitations for Its 5.750% Senior Notes Due 2010 and 6.375% Senior Notes Due 2015 in Connection With Its Proposed Acquisition of Mercks Generic Pharmaceutical Business
2. Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference
3. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
4. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
5. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Adipex-P(R)
6. National Pharmaceutical Council Announces New Strategic Focus, Search for New Leadership
7. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Coreg(R)
8. Provectus Pharmaceuticals, Inc. Begins Phase 2 Clinical Trial for Metastatic Melanoma
9. Par Pharmaceutical Files Form 10-K for 2006 -- Company to Hold First Analysts Meeting September 28, 2007
10. Idenix Pharmaceuticals to Present at Two Upcoming Investor Conferences
11. Pharmaceutical Manufacturing Quality: Optimizing Your Internal Process for FDA Compliance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Consumers have taken a more ... placed more emphasis on patient outcomes. ... in the pharmaceutical industry have evolved beyond just ... companies are focusing on becoming more patient-oriented across ... and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American Respiratory ... testing company, is now able to perform sophisticated lung assessments in ... Medical Technologies , Inc. Patients are no longer ... to ndd,s EasyOne PRO ® , ARL patients like Jeanne R. ... testing done in the comfort of her own home. ...
Breaking Medicine Technology: