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PharmaPoint: Dry Eye Syndrome - UK Drug Forecast and Market Analysis to 2022
Date:12/4/2013

nership strategies by identifying drugs with the most promising sales potential
-Make more informed business decisions from insightful and in-depth analysis of drug performance
-Obtain sales forecast for drugs from 2012-2022 in the UK.

1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 7
1.2 List of Figures 8
2 Introduction 9
2.1 Catalyst 9
2.2 Related Reports 9
3 Disease Overview 11
3.1 Etiology and Pathophysiology 11
3.1.1 Etiology 11
3.1.2 Pathophysiology 13
3.1.3 Classification 15
3.1.4 Prognosis 15
3.1.5 Quality of Life 16
3.2 Symptoms 16
4 Disease Management 18
4.1 Overview 18
4.1.1 Diagnosis Overview 18
4.1.2 Treatment Guidelines 20
4.1.3 Treatment Overview 25
4.2 UK 28
4.2.1 Diagnosis 28
4.2.2 Clinical Practice 28
5 Competitive Assessment 29
5.1 Overview 29
5.2 Strategic Competitor Assessment 29
5.3 Product Profiles – Major Brands 31
5.3.1 Restasis (cyclosporine 0.05% ophthalmic emulsion) 31
5.3.2 Additional Therapies 35
6 Opportunity and Unmet Need 39
6.1 Overview 39
6.2 Diagnostic tests are not specific enough to identify subgroups of patients 40
6.3 Frequent dosing and side effects limit compliance 41
6.4 Lack of physician and patient awareness 42
6.5 Trial design may be a factor in so few drugs being approved 43
6.6 Unmet Needs Gap Analysis 44
6.7 Comprehensive method for measuring dry eye signs and severity levels 45
6.8 Increase treatment rates among milder forms of the disease 46
7 Pipeline Assessment 47
7.1 Overview 47
7.2 Promising drugs in clinical development 48
7.2.1 Lifitegrast 49
7.2.2 CF-101 52
7.2.3 Cyclokat 56
8 Market Outlook 60
8.1 United Kingdom 60
8.1.1 Forecast 60
8.1.2 Key Events
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