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PharmaPoint: Alzheimer’s Disease - UK Drug Forecast and Market Analysis to 2022

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Table of Contents

1 Table of Contents 5
1.1 List of Tables 8
1.2 List of Figures 10
2 Introduction 11
2.1 Catalyst 11
2.2 Related Reports 12
3 Disease Overview 14
3.1 Etiology and Pathophysiology 15
3.1.1 Etiology 15
3.1.2 Pathophysiology 18
3.2 Symptoms 30
4 Disease Management 32
4.1 Diagnosis 32
4.1.1 Probable Alzheimer’s Disease Dementia 33
4.1.2 Possible AD Dementia 34
4.1.3 Probable AD Dementia with Evidence of AD Pathophysiological Process 34
4.1.4 Possible Alzheimer’s Dementia with Evidence of the Alzheimer’s Disease Pathophysiological Process 35
4.1.5 Preclinical AD 35
4.1.6 Mild Cognitive Impairment 36
4.2 Treatment Overview 38
4.3 UK 41
4.3.1 Diagnosis 41
4.3.2 Clinical Practice 41
5 Competitive Assessment 43
5.1 Overview 43
5.2 Strategic Competitor Assessment 43
5.3 Product Profiles - Major Brands 46
5.3.1 Aricept (donepezil hydrochloride) 46
5.3.2 Exelon (rivastigmine, rivastigmine tartrate) 50
5.3.3 Razadyne (galantamine hydrobromide) 55
5.3.4 Namenda (memantine hydrochloride) 59
6 Opportunity and Unmet Need 63
6.1 Unmet Needs Overview 63
6.1.1 Public Awareness 65
6.1.2 Specialized Institutions at Local Levels 66
6.1.3 Screening and Diagnosis 66
6.1.4 Early Intervention 67
6.1.5 Improved Clinical Trial Design 68
6.1.6 Effective Therapy 69
6.1.7 Behavioral Treatments 70
6.2 Gap Analysis 70
6.2.1 Disease Prevention 71
6.2.2 Diagnosis from Biomarkers 72
6.2.3 Behavioral Therapies 73
7 Pipeline Assessment 74
7.1 Overview 74
7.2 E

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