Navigation Links
PharmAthene and Medarex Announce Additional $0.8 Million U.S. Government Appropriation for Continued Development of Anthrax Therapeutic Valortim(TM)
Date:11/6/2007

person, and then is believed to facilitate the entry of additional destructive toxins into the cells. Valortim is designed to target anthrax protective antigen and protect the cells from damage by the anthrax toxins.

Valortim has been administered intravenously and intramuscularly to 46 healthy human volunteers in a completed phase I study, was well tolerated at doses as high as 20 mg/kg (IV), and was not immunogenic. The Phase I data showed that Valortim was safe and well-tolerated. No drug-related Grade 2-4 or serious adverse events were reported. Grade 1 adverse events were reported in 16 of the volunteers overall, with the most common being pain/burning at the injection site for those being dosed intramuscularly (6 subjects). There were also a few mild headaches (3 subjects overall). Pharmacokinetic analysis suggested that doses as low as 1 mg/kg resulted in circulating levels of antibody after a month, with a similar potency for neutralizing anthrax toxin in vitro as was seen with serum obtained from subjects who had been vaccinated with anthrax vaccine. These study results were presented at the 2006 Annual Meeting of the Infectious Diseases Society of America.

Preclinical studies suggest that Valortim has the potential to provide protection against anthrax infection when administered prophylactically (prior to the emergence of symptoms of anthrax infection) and also the potential to be administered therapeutically (once symptoms become evident).

About Anthrax

According to the Centers for Disease Control and Prevention, anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Anthrax most commonly occurs in hoofed mammals and can also infect humans. Symptoms of disease vary depending on how the disease is contracted, but usually occur within seven days after exposure. The serious forms of human anthrax are inhalation anthrax, cutaneous anthrax, and intestinal anthrax. Initial symptoms of inhalatio
'/>"/>

SOURCE PharmAthene, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine news :

1. PharmAthene to Present at the Rodman and Renshaw/Acumen BioFin 9th Annual Healthcare Conference
2. Ono and Medarex Announce Allowance of Investigational New Drug Application for Fully Human Anti-PD1 Antibody
3. Medarex to Present at the JPMorgan Small/Mid Cap Conference
4. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
5. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
6. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
7. HEI, Inc. Announces Sale of RFID Division Assets
8. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
9. Mettler-Toledo International Inc. Announces Webcast of Presentation at Thomas Weisel Partners 2007 Healthcare Conference
10. Z Trim Announces Revocation of Gregory Halpern Severence Agreement
11. Brooke Franchise Corporation Announces Selected July Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... had an aneurysm, she figured an invasive brain surgery and ... said Wakulich, who is 56 years old and lives in ... Then I met Dr. Bernard Bendok who told me about ... was something I didn,t even know was an option." , ... to evaluate the safety and effectiveness of the Microvention Inc. ...
(Date:7/9/2014)... captures heretofore hidden ways that cells are regulated, scientists ... breast cancer cells more likely to metastasize. , What,s ... part by blocking two other proteins that are normally ... disease processes could have unexpected ties. , The ... Nature , points to the possibility of new ...
(Date:7/9/2014)... of stromal support cells and immune cells and ... in the development of diseases could open new ... was the conclusion of a review article by scientists ... Nature . , Prof. Peter Carmeliet: "Consider the ... of cancer cells has been examined in minute detail ...
(Date:7/9/2014)... Researchers have found that fecal transplantation is ... in immunocompromised patients. This is the result of a ... the Center for Women,s Gastrointestinal Medicine at The Women,s ... published online in advance of print in the ... , or C. diff , has increased to ...
(Date:7/9/2014)... The Miriam Hospital have found that people with ... depressed have difficulty sticking to a pulmonary rehabilitation ... women, and screening and brief treatment of depression ... study and its findings are published in print ... obstructive pulmonary disease is a common and often ...
Breaking Medicine News(10 mins):Health News:New type of stent could help some brain aneurysm patients 2Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:Wake-up call for more research into cell metabolism 2Health News:Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile 2Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2
... Expects FDA 510(k) Clearance Before End of 2008; ... Support High Test Sensitivity, CASTLE ROCK, Colo., ... ), an emerging bio-pharmaceutical company dedicated to,the development ... humans, has,outlined plans for submitting its final data ...
... Scientists who study cancer may be prone to drawing ... because they dont appreciate how complex the data ... Georgetown University Medical Center (GUMC) researchers in the January ... review article summing up the state of the field, ...
... Smoke-Free, GLENDALE, Calif., Dec. 27 In anticipation ... Hygienists,Association (CDHA) is calling on smokers to resolve to ... the California Smokers, Helpline., "Smokers shouldn,t feel they ... of CDHA. "We know for a fact that people ...
... leadership and entrepreneurial expertise to ... ... the,creator of Dreamerz, the first ever all-natural sleep beverage, today,announced Gilbert ... newest member of the San Francisco-based company,s,Board of Directors. Pritchard brings ...
... Begin Offering Menu Items in 2007, JOHNSON CITY, ... City Medical Center now have an even more,convenient way ... as the facility began serving Einstein Bros.(R) Bagels menu,items ... The second location serving Einstein Bros. near the ...
... in New Year, VAN NUYS, Calif., Dec. 27 ... cancer/HPV this year,and nearly 4,000 will die from an ... Awareness Month, the National Cervical,Cancer Coalition (NCCC) is focused ... as a screening tool for cervical cancer/HPV and about,vaccines ...
Cached Medicine News:Health News:AspenBio Outlines Steps for FDA 510(k) Clearance of AppyScore(TM), the First Blood-Based Screen/Triage Test for Human Appendicitis 2Health News:AspenBio Outlines Steps for FDA 510(k) Clearance of AppyScore(TM), the First Blood-Based Screen/Triage Test for Human Appendicitis 3Health News:AspenBio Outlines Steps for FDA 510(k) Clearance of AppyScore(TM), the First Blood-Based Screen/Triage Test for Human Appendicitis 4Health News:New research tools are too complex for easy answers, researchers say 2Health News:New research tools are too complex for easy answers, researchers say 3Health News:California Dental Hygienists Urge Smokers to Kick the Habit in 2008 2Health News:Gilbert Pritchard, Jr. Joins Board of Directors at Dreamerz Foods, Inc. 2Health News:Gilbert Pritchard, Jr. Joins Board of Directors at Dreamerz Foods, Inc. 3Health News:Johnson City Medical Center Begins Offering Einstein Bros. Menu Items at Second On Campus Location 2Health News:National Cervical Cancer Coalition Stresses Importance of Screening and Prevention During January Cervical Health Awareness Month 2
(Date:1/15/2014)... Fla. , Jan. 15, 2014  In an unprecedented effort to ... TB in ambulances and other transport vehicles, an advanced and portable ... rescue personnel for the first time. In order ... with these deadly pathogens, West Palm Beach ...
(Date:1/15/2014)... Jan. 15, 2014 The Cadence Fitness & Health ... by the Medical Fitness Association, a non-profit organization assisting ... full potential. The Cadence Fitness & Health Center is ... and second in the Chicagoland area. "The ...
(Date:1/15/2014)... Quebec , Jan. 15, 2014  Valeant Pharmaceuticals International, ... announced that the applicable waiting period under the Hart-Scott-Rodino ... the previously announced tender offer by its indirect wholly-owned ... outstanding shares of common stock of Solta Medical, Inc. ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... NxStage ® Medical , Inc. (Nasdaq: NXTM ... announced the latest interim findings from its FREEDOM ... which found daily home hemodialysis treatments with the ... in various physical and mental quality of life measures. ...
... Senate passed S. 3187, its version of the Prescription ... to mitigate drug shortages, most notably mandating an early ... professional society concerned with the causes and treatment of ... in blood cancers such as leukemia, lymphoma, and myeloma, ...
Cached Medicine Technology:FREEDOM Study Data: Patients Experience Sustained Quality of Life Benefits with More Frequent Home Hemodialysis with the NxStage System One 2FREEDOM Study Data: Patients Experience Sustained Quality of Life Benefits with More Frequent Home Hemodialysis with the NxStage System One 3American Society of Hematology Statement on Senate Passage of Prescription Drug User Fee Act (PDUFA) 2
Indications For Usage: ,Single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intended to be replaced at least once every 24 hours...
... Portex® Thermovent® T helps provide protection to the ... small and extremely lightweight making it ideal for ... a high rate of heat and moisture recovery, ... ,All HMEs and filters have ISO standard ...
... Portex® Thermovent® T helps provide protection to the ... small and extremely lightweight making it ideal for ... a high rate of heat and moisture recovery, ... ,All HMEs and filters have ISO standard ...
... provide protection to the exposed airway of the ... making it ideal for active young children as ... heat and moisture recovery, it ensures patient comfort ... filters have ISO standard tapered ends to assure ...
Medicine Products: