Pfizer's work on penicillin for World War II becomes a National Historic Chemica...(se the yields. Eventually the company be...),Health
se the yields. Eventually the company began to use a fermentation process in deep tanks rather than shallow pans and flasks.
Pfizer's technological advances in using deep tanks for fermentation proved critical when Allied governments sent out the call for penicillin. Initially, Pfizer researchers, led by Jasper Kane, used shallow flasks and pans like those that were used for citric acid, and they made gradual progress in improving penicillin's potency and purity. The breakthrough came when Kane suggested a different approach: the deep-tank method that proved successful for gluconic acid. They needed huge tanks that could hold thousands of gallons of "fermentation liquor." Pfizer purchased an old ice plant in Brooklyn that had the necessary refrigeration equipment and converted it into a penicillin factory which opened on March 1, 1944.
The plant contained fourteen 7,500-gallon tanks and soon the company was producing more penicillin in one month than it had in all of 1943. Most of the penicillin that went ashore with Allied forces on D-Day came from Pfizer's Brooklyn facility.
After World War II, Pfizer applied its deep-tank fermentation to manufacture streptomycin [a National Historic Chemical Landmark], an important antibiotic discovered by Dr. Selman Waksman and colleagues at Rutgers, and then to Terramycin, the first antibiotic developed exclusively by the company's scientists. Terramycin, which proved effective against a wide range of deadly bacteria, was developed from a microorganism in soil from the American Midwest ("Terramycin" is derived from the Latin for "earth fungus").
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| Contact: Charmayne Marsh c_marsh@acs.org 202-872-4445 American Chemical Society Source:Eurekalert |
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