Navigation Links
Personalizing prostate cancer screenings
Date:4/24/2013

CHICAGO --- With the help of genetics, prostate specific antigen (PSA) screenings may become more accurate and reduce the number of unnecessary prostate biopsies, according to a new study from Northwestern Medicine.

Personalized PSA testing using genetic variants could account for an 18 percent reduction in the number of men who likely would have undergone unnecessary biopsies, according to the study. It will be published in the May 2013 issue of The Journal of Urology.

The high survival rate of men with prostate cancer is largely a reflection of PSA testing, but support for the widespread use of the screening method has been the topic of recent debate because of its limited specificity.

"By utilizing a person's genetic makeup we can personalize care when he comes in for a PSA screening," said Brian Helfand, M.D., lead author of the study. "We may be able to prevent some men from having an unnecessary biopsy and prevent a delay in biopsy for men who may have an aggressive disease."

Helfand is an adjunct assistant professor of cell and molecular biology at Northwestern University Feinberg School of Medicine.

For 98 percent of the men, genetic adjustment of PSA levels did not change the outcome of their screening. But genetic correction was important for the 17 men who were reclassified as no longer meeting biopsy criteria and the three whose condition was up classified, and it was recommended they get a biopsy, based on their genetic adjustment.

"If our results are validated, genetic adjustments could potentially prevent 15 to 20 percent of prostate biopsies," said William J. Catalona, M.D., senior author of the study. "Since it has been estimated that more than 1 million biopsies are performed in the United States annually, this could translate into 150,000 to 200,000 potentially unnecessary biopsies every year."

In addition to cost savings, fewer biopsies mean fewer adverse outcomes, such as
'/>"/>

Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Personalizing prostate specific antigen testing may improve specificity, reduce biopsies
2. Personalizing medicine: New American Chemical Society Prized Science video
3. Personalizing biologic treatment to individual patients with rheuatoid arthritis is cost-effective
4. Obesity Linked to Prostate Cancer, Study Finds
5. Obese men at high risk for prostate cancer even after benign biopsy
6. Laser optics plus ultrasound imaging holds promise as a noninvasive test for prostate cancer
7. Gene-expression signature may signify risk for recurrence, metastasis in prostate cancer
8. New Procedure May Shrink Enlarged Prostate Without Surgery
9. Can Selenium Lower Risk of Advanced Prostate Cancer?
10. Counting copy numbers characterises prostate cancer
11. Prostate cancer treatment study changing the way doctors practice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... Coral Gables, Florida (PRWEB) November 28, 2014 ... for Thanksgiving, Turbana and Sendik’s will present Feeding America ... partnered with Sendik’s Food Market to donate a portion ... Turbana participated in Sendik’s promotion, “7 Days, 7 Ways ... Wednesday throughout fall, Fyffes pineapples were two for $4 ...
(Date:11/28/2014)... Texas (PRWEB) November 28, 2014 Dr. Paul Vitenas, ... will hold a Glitter & Glow Holiday Event for those in ... treatments offered at his practice. Glitter & Glow will take place ... Dr. Vitenas’ new location in the heart of Houston at 4208 ... of holidays and hope that you will come and celebrate the ...
(Date:11/28/2014)... on seconds at Thanksgiving Day dinner this year? If you ... disease (GERD) -- a few steps may help minimize the ... specialist at Lenox Hill Hospital in New York City, offers ... Pace yourself. Rather than have one big ... It,s also a good idea to have a healthy snack ...
(Date:11/28/2014)... CA (PRWEB) November 28, 2014 ... online, reported during the hugely popular, 2014 MTV ... antismoking organization Truth launched ground-breaking celebrity centered television ... The MTV viewership figures were estimated by ... antismoking ads placed the spotlight on celebrities photographed ...
(Date:11/28/2014)... Miami, FL (PRWEB) November 28, 2014 Lice ... service areas of its in-home head lice service for ... location in the center of Coral Gables on Pone De-leon ... in Bay Harbor Islands that service Miami-Dade & Broward. ... physical salon in South Florida which has been treating families ...
Breaking Medicine News(10 mins):Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 3Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 2Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 3Health News:Don't Let Chronic Heartburn Spoil Your Thanksgiving Feast 2Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 2Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 3Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 4Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 5Health News:Lice Troopers Lice Removal Service Expands in Miami-Dade 2
... markets Aricept with Pfizer Inc. Aricept is already approved in ... but at present it was being tested in patients with ... Alzheimer's disease. ,But the shocking results show that ... clinical trial held at Japan's Eisai Co. ,There ...
... Dr Charles Reynolds at the University of Pittsburgh which was ... , The study’s main aim was to analyze the effect ... It is one of the longest studies ever in ... for longer periods, perhaps even for life, in patients who ...
... increasing number of addicts. Health authorities are warning of the ... with the consequences. ,Statistics show that about one ... Vincent's Hospital has recorded a five-fold increase in patients suffering ... in Australia. , The reason being that ice ...
... condition that affects millions of people. Scientists at the University ... leading to eczema and asthma. ,This gene produces ... outermost layers of the skin. It prevents bacteria and viruses ... to prevent the skin from drying. Reduction or absence of ...
... soon going to have more up market looking// medical stores ... supply free medicines to the patients., ,Apparently the ... ‘swanky medical stores’. These will be located at the entrance ... (BPL)’ card holders..., ,Mr Ashok said that these ...
... approval to formation of a Health Task Force for India.//, ... in the health sector in India which includes doctors, nurses ... commission on macroeconomics and health in its report,” a statement ... were also growing opportunities with India emerging as a major ...
Cached Medicine News:Health News:Drugs Are Effective In Treating Depression and Preventing Recurrence 2Health News:Gene That Causes Dry Skin, Identified 2
(Date:11/26/2014)... 2014  Perrigo Company plc ("Perrigo") (NYSE: ... Affordable Healthcare Products®," today announced the closing of Perrigo,s ... of 6,809,210 ordinary shares at a public offering price ... the option to purchase up to an additional 888,157 ... Capital Inc., as representatives of the several underwriters. ...
(Date:11/26/2014)... THE WOODLANDS, Texas , Nov. 26, 2014 ... LXRX ) today announced the completion of previously ... of $280.0 million.  After fees and estimated offering ... million from the transactions.  The transactions consisted of: ... shares of common stock, pursuant to a registration ...
(Date:11/26/2014)... CUMBERLAND, Md. , Nov. 26, 2014  Over ... half of those suffer from this pain daily. Chronic ... specialty of pain management is born to fulfill the ... treat all types of pain. On October ... to the Cumberland, Maryland community.  ...
Breaking Medicine Technology:Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3New Pain Management Center Opens in Cumberland, Md. 2
... Craftsmanship have produced the finest ... Ocutek now makes them available ... the coveted Meisterbrief certificate, which ... qualified to become Ocutek instrument ...
... German Craftsmanship have produced the ... world. Ocutek now makes them ... of the coveted Meisterbrief certificate, ... are qualified to become Ocutek ...
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medicine Products: