Navigation Links
Personalizing medicine to prevent pandemics
Date:3/29/2010

What makes some viral infections fatal and others much less severe is largely a mystery. It is thought that a part of the variability can be attributed to differences in how individuals respond to infection.

Professor Michael Katze, presenting at the Society for General Microbiology's spring meeting in Edinburgh today, describes how computer modelling could be a powerful tool to allow treatments to be tailored to individuals. This approach could ultimately prevent future pandemics.

Professor Katze, from the University of Washington in Seattle reveals how 'systems biology' methods could successfully tackle viral infections, such as HIV and hepatitis C virus, for which there is still no effective vaccine or treatment.

"Systems biology is like a Rubik's cube it's a matrix that integrates computational models, experimental systems and high-throughput data in a variety of combinations to solve the puzzle of virus-host interactions. It provides a powerful new approach to virology, drug discovery and vaccine development," explained Professor Katze.

Computer models of the whole cell can be made and tested by simulating virus-induced changes and monitoring the whole cell response. Comparing the model to real biological examples allows the model to be refined and allows researchers to make further predictions about how different cells respond to different changes.

Improved animal models may help us understand how differences in an individual's genetic make-up affect HIV development. "Determining which host genes affect HIV progression has been relatively slow using the current techniques in isolation," remarked Professor Katze. "Some current studies indicate there is a link between genes that affect how virus particles enter the host cell and disease progression," he continued.

Identifying the molecules produced from these host genes could provide a method to effectively detect disease, predict how individuals respond to infection and even establish how effective a vaccine is. "If this becomes as easy as doing a simple blood test, we will be equipped to provide the most effective treatment to the individual. This will limit the spread of the virus which in turn could help protect the population as a whole and even prevent the next pandemic," suggested Professor Katze.


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related medicine news :

1. Personalizing cancer: Creating biomarkers from tumor DNA
2. Children with food allergies should carry 2 doses of emergency medicine
3. ATS endorses pay-for-performance for pulmonary, critical care and sleep medicine
4. New York Sports Medicine Offers Platelet Rich Plasma Therapy For Treatment of Injury
5. Rutgers historian puts 50th anniversary of the pill into cultural medicine cabinet
6. The European Medicines Agency Completes Validation Stage for InterMunes Marketing Authorization Application for pirfenidone
7. New York College of Osteopathic Medicine (NYCOM) at NYIT Awarded $1 Million Federal Grant
8. Ingenious Med Founder, Steven Liu, Earns Senior Fellow in Hospital Medicine Designation
9. Modern medicine conquers witchcraft
10. Patients Who Take a Proton-Pump Inhibitor With Medicine to Prevent Blood Clots Are Less Likely to Be Hospitalized for Bleeding Ulcers
11. PCU College of Holistic Medicine Launches New Website
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... ... 17, 2017 , ... Park Cities Pet Sitter President, Joette White, has been ... Radio network. The episode, which was posted this week, features a 30-minute interview ... to Park Cities Pet Sitter’s being awarded the 2017 National Association of Professional Pet ...
(Date:2/18/2017)... ... February 18, 2017 , ... A new directory ... contact points to easily connect elderly veterans of America's armed forces to a ... It also conveys material on this year's increase in the Veterans Pension with ...
(Date:2/17/2017)... ... February 17, 2017 , ... While EHR data has ... introduced an innovative workstation designed to reduce nursing fatigue while enhancing productivity. Based ... Workstation offers a lightweight, highly mobile, multi-functional alternative to the limitations of handheld ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... that allow for the electronic prescribing of controlled and non-controlled substances plus the ... percent of pharmacies in the United States now accept electronic prescriptions, according to ...
(Date:2/17/2017)... Falls Church, VA (PRWEB) , ... ... ... to Integrate FDA Device Approval and Reimbursement , **An FDAnews Webinar**, Feb. ... , What are the critical reimbursement questions manufacturers should be asking ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , Feb 17, 2017 Research and Markets has ... Business Report" report to their offering. ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , and Rest of World. Annual ... a six-year historic analysis is provided for these markets. Market data and ...
(Date:2/17/2017)... , Feb. 17, 2017   Risperdal lawsuits ... effects allegedly associated with use of the atypical antipsychotic ... Philadelphia Court of Common Pleas, where the ... tort program. According to a notice posted on the ... convene a meeting on March 9, 2017 at 11:00 ...
(Date:2/17/2017)... 17, 2017   FormFast , the leader in ... partnership with Engage , one of the largest ... . FormFast will serve as the forms automation and ... MEDITECH .  FormFast is a ... complement and enhance the electronic health record. FormFast,s technology ...
Breaking Medicine Technology: