Navigation Links
Personalizing medicine to prevent pandemics
Date:3/29/2010

What makes some viral infections fatal and others much less severe is largely a mystery. It is thought that a part of the variability can be attributed to differences in how individuals respond to infection.

Professor Michael Katze, presenting at the Society for General Microbiology's spring meeting in Edinburgh today, describes how computer modelling could be a powerful tool to allow treatments to be tailored to individuals. This approach could ultimately prevent future pandemics.

Professor Katze, from the University of Washington in Seattle reveals how 'systems biology' methods could successfully tackle viral infections, such as HIV and hepatitis C virus, for which there is still no effective vaccine or treatment.

"Systems biology is like a Rubik's cube it's a matrix that integrates computational models, experimental systems and high-throughput data in a variety of combinations to solve the puzzle of virus-host interactions. It provides a powerful new approach to virology, drug discovery and vaccine development," explained Professor Katze.

Computer models of the whole cell can be made and tested by simulating virus-induced changes and monitoring the whole cell response. Comparing the model to real biological examples allows the model to be refined and allows researchers to make further predictions about how different cells respond to different changes.

Improved animal models may help us understand how differences in an individual's genetic make-up affect HIV development. "Determining which host genes affect HIV progression has been relatively slow using the current techniques in isolation," remarked Professor Katze. "Some current studies indicate there is a link between genes that affect how virus particles enter the host cell and disease progression," he continued.

Identifying the molecules produced from these host genes could provide a method to effectively detect disease, predict how individuals respond to infection and even establish how effective a vaccine is. "If this becomes as easy as doing a simple blood test, we will be equipped to provide the most effective treatment to the individual. This will limit the spread of the virus which in turn could help protect the population as a whole and even prevent the next pandemic," suggested Professor Katze.


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related medicine news :

1. Personalizing cancer: Creating biomarkers from tumor DNA
2. Children with food allergies should carry 2 doses of emergency medicine
3. ATS endorses pay-for-performance for pulmonary, critical care and sleep medicine
4. New York Sports Medicine Offers Platelet Rich Plasma Therapy For Treatment of Injury
5. Rutgers historian puts 50th anniversary of the pill into cultural medicine cabinet
6. The European Medicines Agency Completes Validation Stage for InterMunes Marketing Authorization Application for pirfenidone
7. New York College of Osteopathic Medicine (NYCOM) at NYIT Awarded $1 Million Federal Grant
8. Ingenious Med Founder, Steven Liu, Earns Senior Fellow in Hospital Medicine Designation
9. Modern medicine conquers witchcraft
10. Patients Who Take a Proton-Pump Inhibitor With Medicine to Prevent Blood Clots Are Less Likely to Be Hospitalized for Bleeding Ulcers
11. PCU College of Holistic Medicine Launches New Website
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... June 27, 2017 , ... East Los Angeles dentist, ... indicate about early life experiences. What happens to a woman during pregnancy can have ... birth can also take a toll on a baby’s long-term health. This study, which ...
(Date:6/26/2017)... , ... June 26, 2017 , ... Torrance dentist, Dr. ... can be one of the most noticeable aspects of a person’s appearance. A healthy, ... everyone is born with beautiful, balanced teeth, everyone can have the smile of their ...
(Date:6/26/2017)... ... June 26, 2017 , ... Dr. ... Medicine Specialists, in collaboration with the Fertility Center of California, is pleased to ... (percutaneous epidydimal sperm aspiration) and TESA (percutaneous testicular sperm extraction). These minimally invasive ...
(Date:6/26/2017)... , ... June 26, 2017 , ... ... to a recent review of government data released by the United Soybean Board. ... management practices, Maryland’s soybean farmers have increased their productivity on less land per ...
(Date:6/26/2017)... Tahoe, CA (PRWEB) , ... June 26, 2017 , ... ... 10,000 qualified mental health professionals in every state across the country to join its ... easy and rewarding way for therapists to reach a substantially greater number of people ...
Breaking Medicine News(10 mins):
(Date:6/3/2017)... June 3, 2017  Eli Lilly and Company ... results from the Phase 3 MONARCH 2 study ... 6 inhibitor, in combination with fulvestrant, significantly improved ... alone in women with hormone-receptor-positive (HR+), human epidermal ... who have relapsed or progressed after endocrine therapy ...
(Date:5/30/2017)... , May 30, 2017 Therapix Biosciences Ltd. ... specializing in the development of cannabinoid-based drugs, today ... company overview at three upcoming scientific and investor ... LD Micro Invitational: ... Date:                     ...
(Date:5/23/2017)... , May 23, 2017  Leaf Healthcare, ... innovative medical devices for pressure ulcer prevention, will ... American Association of Critical Care Nurses, National Teaching ... 22-25. The Leaf Patient Monitoring System ... for the hospital environment.  The system seamlessly tracks ...
Breaking Medicine Technology: