Navigation Links
Personalizing medicine to prevent pandemics
Date:3/29/2010

What makes some viral infections fatal and others much less severe is largely a mystery. It is thought that a part of the variability can be attributed to differences in how individuals respond to infection.

Professor Michael Katze, presenting at the Society for General Microbiology's spring meeting in Edinburgh today, describes how computer modelling could be a powerful tool to allow treatments to be tailored to individuals. This approach could ultimately prevent future pandemics.

Professor Katze, from the University of Washington in Seattle reveals how 'systems biology' methods could successfully tackle viral infections, such as HIV and hepatitis C virus, for which there is still no effective vaccine or treatment.

"Systems biology is like a Rubik's cube it's a matrix that integrates computational models, experimental systems and high-throughput data in a variety of combinations to solve the puzzle of virus-host interactions. It provides a powerful new approach to virology, drug discovery and vaccine development," explained Professor Katze.

Computer models of the whole cell can be made and tested by simulating virus-induced changes and monitoring the whole cell response. Comparing the model to real biological examples allows the model to be refined and allows researchers to make further predictions about how different cells respond to different changes.

Improved animal models may help us understand how differences in an individual's genetic make-up affect HIV development. "Determining which host genes affect HIV progression has been relatively slow using the current techniques in isolation," remarked Professor Katze. "Some current studies indicate there is a link between genes that affect how virus particles enter the host cell and disease progression," he continued.

Identifying the molecules produced from these host genes could provide a method to effectively detect disease, predict how individuals respond to infection and even establish how effective a vaccine is. "If this becomes as easy as doing a simple blood test, we will be equipped to provide the most effective treatment to the individual. This will limit the spread of the virus which in turn could help protect the population as a whole and even prevent the next pandemic," suggested Professor Katze.


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related medicine news :

1. Personalizing cancer: Creating biomarkers from tumor DNA
2. Children with food allergies should carry 2 doses of emergency medicine
3. ATS endorses pay-for-performance for pulmonary, critical care and sleep medicine
4. New York Sports Medicine Offers Platelet Rich Plasma Therapy For Treatment of Injury
5. Rutgers historian puts 50th anniversary of the pill into cultural medicine cabinet
6. The European Medicines Agency Completes Validation Stage for InterMunes Marketing Authorization Application for pirfenidone
7. New York College of Osteopathic Medicine (NYCOM) at NYIT Awarded $1 Million Federal Grant
8. Ingenious Med Founder, Steven Liu, Earns Senior Fellow in Hospital Medicine Designation
9. Modern medicine conquers witchcraft
10. Patients Who Take a Proton-Pump Inhibitor With Medicine to Prevent Blood Clots Are Less Likely to Be Hospitalized for Bleeding Ulcers
11. PCU College of Holistic Medicine Launches New Website
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... FL (PRWEB) , ... February 23, 2017 , ... ... non-profit organization devoted exclusively to funding innovative lymphoma research and serving the lymphoma ... – will return to the La Gorce Country Club in Miami Beach to ...
(Date:2/23/2017)... ... February 23, 2017 , ... Los Angeles-based weight loss ... WE TV’s “Mama June: From Not to Hot,” which will begin airing on February ... Shannon, known to millions from the 2012 reality television series, “Here Comes Honey Boo ...
(Date:2/23/2017)... ... February 23, 2017 , ... EBSCO ... the National Institute for Health and Care Excellence (NICE) framework. The ... National Health Service (NHS) to search, order and purchase medical and healthcare-related content ...
(Date:2/23/2017)... ... 2017 , ... Pink Pig Publishing LLC announces the launch ... the world from different perspectives. By providing a place for people of all ... empathy, and find greater happiness. , "Our approach to structuring content is ...
(Date:2/23/2017)... NJ (PRWEB) , ... February 23, 2017 , ... ... the pre-eminent publication and community for those in the fight against cancer, has ... important in their success. HRA will release top-line findings in a webinar, ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb. 23, 2017 Non-alcoholic ... on the various drugs being developed for ... all the drugs that are in various ... The pipeline focuses on novel pharmacologic drugs ... stem cell therapies, recombinant proteins and RNA-based ...
(Date:2/24/2017)... , Feb. 24, 2017  Xynomic Pharmaceuticals, Inc., ... announced that it has acquired exclusive worldwide rights ... best-in-class innovative HDAC inhibitor targeting hematological and solid ... 14 Phase 1 and 2 clinical trials of ... have already been completed, demonstrating that ...
(Date:2/23/2017)... DUBLIN , Feb 23, 2017 Research ... Disorder Drugs Price Analysis and Strategies - 2016" report to ... ... - 2016, provides drug pricing data and benchmarks in the global ... What are the key drugs marketed ...
Breaking Medicine Technology: