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Personalizing medicine: New research shows potential of targeted therapies for cancer
Date:6/16/2008

NEW ORLEANS, La.A new study, presented at the SNM 55th Annual Meeting, shows the potential to pre-target the treatment of cancer cellsbringing personalized medicine one step closer from the laboratory to patients. By combining new molecular imaging techniques with targeted therapy, pretargeting offers cancer patients a more individualized treatment that can increase the effectiveness of therapies and minimize discomfort experienced during treatment.

In traditional radioimmunoimaging (RAII), radioisotopes are linked directly to antibodies and are delivered together to tumor targets. However, antibodies are relatively large molecules designed to remain in the bloodstream for a long period of time to fight infections, and their slow blood clearance can present difficulties when they are used to carry radioactive materials. The excessive blood-pool activity masks the radioisotope uptake in tumor lesions, thereby lowering the sensitivity and limiting the selectivity of traditional RAII.

"This study demonstrates the advantages of pretargetingan alternative strategy that uses a 'two-step' approach to the delivery of radioisotopeswhen applied to the imaging of tumors using a combination of radioisotope and antibody or RAII," said Otto Boerman, professor in the department of nuclear medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, and lead researcher of this study.

According to Boerman, in this process a bispecific monoclonal antibody (bsMAb), with one arm that recognizes a tumor-associated antigen and another arm that recognizes a peptide carrying an imaging agent, is given as a first injection. When the non-tumor-bound bsMAb has substantially cleared non-target tissues and has reached a maximum level in the tumor, the bsMAb-recognizable imaging agent is given. The latter agent either targets the bsMAb localized at the tumor or is rapidly removed in the urine. Because the delivery of imaging isotopes is rapid and
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Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

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