Navigation Links
Personalizing medicine: New research shows potential of targeted therapies for cancer
Date:6/16/2008

NEW ORLEANS, La.A new study, presented at the SNM 55th Annual Meeting, shows the potential to pre-target the treatment of cancer cellsbringing personalized medicine one step closer from the laboratory to patients. By combining new molecular imaging techniques with targeted therapy, pretargeting offers cancer patients a more individualized treatment that can increase the effectiveness of therapies and minimize discomfort experienced during treatment.

In traditional radioimmunoimaging (RAII), radioisotopes are linked directly to antibodies and are delivered together to tumor targets. However, antibodies are relatively large molecules designed to remain in the bloodstream for a long period of time to fight infections, and their slow blood clearance can present difficulties when they are used to carry radioactive materials. The excessive blood-pool activity masks the radioisotope uptake in tumor lesions, thereby lowering the sensitivity and limiting the selectivity of traditional RAII.

"This study demonstrates the advantages of pretargetingan alternative strategy that uses a 'two-step' approach to the delivery of radioisotopeswhen applied to the imaging of tumors using a combination of radioisotope and antibody or RAII," said Otto Boerman, professor in the department of nuclear medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, and lead researcher of this study.

According to Boerman, in this process a bispecific monoclonal antibody (bsMAb), with one arm that recognizes a tumor-associated antigen and another arm that recognizes a peptide carrying an imaging agent, is given as a first injection. When the non-tumor-bound bsMAb has substantially cleared non-target tissues and has reached a maximum level in the tumor, the bsMAb-recognizable imaging agent is given. The latter agent either targets the bsMAb localized at the tumor or is rapidly removed in the urine. Because the delivery of imaging isotopes is rapid and
'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The Changing Face of Medicine: National Medical Fellowships Annual Awards Gala Honors Three Fellows
2. Measuring medicine: How new technologies could help doctors predict patient outcomes
3. Stanford researchers find culprit in aging muscles that heal poorly
4. Children of depressed moms do better when dad is involved, SLU researcher finds
5. UCLA researchers identify markers that may predict diabetes in still-healthy people
6. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
7. New research shows how chronic stress worsens neurodegenerative disease course
8. New research explores newborn in-hospital weight loss
9. Research may unlock mystery of autisms origin in the brain
10. Bipolar disorder relapses halved by Melbourne researchers
11. HIVs impact in Zimbabwe explored in new research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... July 12, 2014 In ... report, ‘cognitive assessment and training’ is defined ... assess, train, or enhance cognitive functions. These ... as in dementia screening, clinical trials, driver’s ... learning, self assessment, brain training, and employers’ ...
(Date:7/12/2014)... 12, 2014 Tylenol lawsuits ( ... move forward in the federal multidistrict litigation underway ... Bernstein Liebhard LLP reports. According to a filing ... F. Stengel has ordered the deposition of a ... found that the witness’s testimony concerning the marketing ...
(Date:7/12/2014)... 2014 "The second toes cross over the ... to wear shoes," said an inventor from East Hartford, Conn. ... this from happening. , He then created a prototype of ... the second and big toes from overlapping. This avoids discomfort ... Ergonomic and easy to use, it's ideal for people with ...
(Date:7/12/2014)... York (PRWEB) July 12, 2014 As ... move forward in U.S. courts, Bernstein Liebhard LLP notes ... metal ion levels to the failure of metal-on-metal hip ... issue of The Journal of Bone & Joint Surgery, ... unilateral Articular Surface Replacement prostheses at least twelve months ...
(Date:7/12/2014)... “Critical Care Therapeutics in Major ... Four-Factor PCCs and Recombinant Products to Drive Market,” ... market in the US, UK, France, Germany, Italy, ... estimation of market size for 2013, along with ... indications that are being treated using the five ...
Breaking Medicine News(10 mins):Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 2Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 5Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 4Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6
... arrested for mailing thousands of anthrax hoax ... mailed to US President George W Bush. ... allegedly threatened to use a weapon of ... that the letters were mailed to government ...
... Pennsylvania school of medicine have found that patients who had ... arteries in head are in the risk of developing a ... Professor Scott Kasner and researchers is to be published in ... may help in early detection of second stroke and it ...
... Indian State of Kerala fell ill and were admitted to ... // District Collector N. Ayappan said the condition of the ... and Government School at Manacuad, are stable. The district administration ... free meal scheme, and the chances of sabotage have not ...
... caused in human beings due to an excessive use ... which are useful to human beings. // This causes ... who have been undergoing treatment with antibiotics. ... life-threatening complications. But scientists say it has also begun ...
... Engineering Center (IEEC) of the Binghamton University has ... the New York State Office of Science, Technology ... of the Microelectronics Research in the roll-to-roll format. ... funding such initiatives, recognized by the New York ...
... meeting with Boston Scientific to talk about the repairs in ... held in 2001 with Schering-Plough // about problems with its ... to make any amendments. This provoked the FDA to withhold ... solve this problem Raul E. Cesan, the company's president and ...
Cached Medicine News:Health News:$ 1.7 Million NYSTAR Award for Binghamton University to Flex Electronics Research Muscle. 2
(Date:7/10/2014)... 11. Juli 2014  Dilon Technologies, ... die molekulare Bildgebung, einschließlich molekularer Bildgebung ... CE-Zulassung für sein Navigator ® -Gamma-Sondensystem ... das Produkt jetzt europaweit vertreiben. Dilon ... der europäischen Länder ausgedehnt und bereits ...
(Date:7/10/2014)... SAN DIEGO , July 10, 2014  RESMED INC. ... report its fourth quarter and fiscal year ended June 30, ... York Stock Exchange market close. A press release with ResMed,s ... and the company will host a webcast to discuss operating ... scheduled to begin at 1:30 p.m. US Pacific Time and ...
(Date:7/10/2014)... , July 10, 2014   Ventana Medical Systems, ... announced it has entered into an agreement with Merck ... as EMD Serono in the United States ... collaborate with Merck KGaA,s biopharmaceutical division on the development ... undisclosed target using Ventana,s proprietary diagnostic assays. In alignment ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
The PC4200h is the largest capacity platelet incubator available. It features a built-in agitator with a capacity of 396 random bags (132 apheresis)....
The PC4200i is the largest capacity platelet incubator available. It features a built-in agitator with a capacity of 396 random bags (132 apheresis)....
... Platelet incubators hold rotators ... Incubator temperature can be set ... from 15C to 40C (59F ... 0.5C from top to bottom. ...
ELISA for detection of Anti-Gliadin IgA....
Medicine Products: