Navigation Links
Personalizing biologic treatment to individual patients with rheuatoid arthritis is cost-effective

Berlin, Germany, June 7 2012: Data presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, demonstrates that tailoring biologic treatment to individual patients with rheumatoid arthritis (RA) can reduce total costs by 2,595,557 per 272 patients over 3 years (95 percentile range -2,983,760 to -2,211,755), whilst increasing effectiveness by an average of 3.67 quality-adjusted life years (QALYs)*. Cost savings were mostly on drug costs.

The Dutch study, which investigated 272 patients with RA starting adalimumab treatment, measured DAS28** HAQ*** and biologic use over three years. A treatment protocol for personalised care was defined in which EULAR**** response and adalimumab serum drug level test results at six months determined whether adalimumab treatment was continued or discontinued, dosing was altered or, in case of non-response, another biological treatment was started. Using a patient level Markov model, outcomes in DAS28, HAQ, and biologic use for the personalised care group were simulated and compared to the observed drug use and disease course.

Charlotte Krieckaert from the Jan van Breemen Research Institute, Reade, The Netherlands and lead author of the study stated: "Governments and health authorities around the world are looking to save money by cutting costs and providing reduced access to more expensive treatments. This study demonstrates that with careful monitoring and testing disease activity at six months, costs for RA treatment can be reduced and treatment effectiveness can actually increase."

In total, 2,562,494 was saved on biological drug costs and testing costs amounted to 10,872, resulting in an average incremental cost-effectiveness ratio (ICER)***** of -707,236 per QALY gained. Personalised care saved costs and was more effective in 77.6% of simulations, but was cost saving and less effective in 22.4%.


Contact: Candice Debleu
European League Against Rheumatism

Page: 1

Related medicine news :

1. Personalizing cancer: Creating biomarkers from tumor DNA
2. Personalizing medicine to prevent pandemics
3. Mayo researchers find biomarkers for personalizing radiation cancer treatment
4. Study carried out into biological risks of eating reptiles
5. Biological clock could be a key to better health, longer life
6. New method to grow arteries could lead to biological bypass for heart disease
7. Biologic Joint Reconstruction Using Stem Cells Proven Successful In Patients With Arthritis
8. U of T researchers crack splicing code, solve a mystery underlying biological complexity
9. Adolescent brains biologically wired to engage in risky behavior, study finds
10. Biologics-naive juvenile idiopathic arthritis patients have elevated risk of cancer
11. Length of biological marker associated with risk of cancer
Post Your Comments:
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Consumers have taken ... regulators/payers have placed more emphasis on patient outcomes. ... support programs in the pharmaceutical industry have evolved ... Consequently, pharmaceutical companies are focusing on becoming more ... providing products and services that improve health. ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
Breaking Medicine Technology: