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Personalized vaccine for lymphoma patients extends disease-free survival by nearly 2 years
Date:12/6/2010

vidence in the scientific literature that IgG is not as immunogenic or causes immune suppression or tolerance, compared with IgM," Schuster says, "but no one has tested this hypothesis in a clinical trial." Although this new analysis was not included in the original trial design, Schuster thinks its importance is clear. "What this analysis is doing is telling us potential ways to make better vaccines," he says. "And it tells us that we should continue efforts to develop vaccines as part of our treatment for lymphoma."

In fact, the new analysis may reveal the very reason that previous attempts to make an effective idiotype vaccine have not produced encouraging results. The technology used to develop idiotype vaccines in other trials engineered all the idiotype proteins into an IgG-type. By contrast, this trial used a technique that didn't restrict idiotype vaccine production to IgG, but rather included whatever protein was native to the patients' tumors.

To confirm their novel results, Schuster's team plans to launch a new trial next year using the same vaccine approach, but this time they will divide patients at the outset, according to whether their idiotype protein is an IgM- or IgG-type.


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Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
Source:Eurekalert

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