Navigation Links
Personalized vaccine for lymphoma patients extends disease-free survival by nearly 2 years
Date:12/6/2010

(ORLANDO, Fla.) A personalized vaccine is a powerful therapy to prevent recurrence among certain follicular lymphoma patients, according to the latest results of ongoing research led by the University of Pennsylvania School of Medicine. The new findings show that when these patients whose tumors are marked by a specific protein that may be present in up to half of people with this type of cancer -- receive a vaccine made from their own tumor cells, disease-free survival is improved by nearly two years, compared with patients who receive a placebo. Based on the new analysis, the team thinks they can explain why the results of previous trials of similar therapeutic cancer vaccines were not as strong as expected.

"The treatment effect of the personalized vaccine is stunning in our trial," says Stephen J. Schuster, MD, an associate professor in the division of Hematology-Oncology and director of the Lymphoma Program at Penn's Abramson Cancer Center. Schuster will present data from a randomized, double-blind, phase III multicenter clinical trial on Monday, Dec. 6 at the annual meeting of the American Society of Hematology (ASH). "Our work stands to revolutionize the approach to personalized vaccine development in lymphoma, and bring new hope to patients who are diagnosed with all types of the disease. This is paradigm changing," Schuster says.

The majority of follicular lymphoma patients who make up about 30 percent of the 66,000 patients diagnosed with non-Hodgkin lymphoma each year -- initially respond to monoclonal antibody therapy and chemotherapy but later suffer a relapse. They may be helped by subsequent rounds of chemotherapy, but eventually their disease becomes resistant to these drugs.

Each patient's lymphoma tumor carries a unique protein on the cell surface, called an idiotype protein. The idiotype protein is part of a larger protein on the cell's surface which can be one of several so-called "isotypes", usually either the
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
2. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
3. DSM Personalized Nutrition Webinar Explores Benefits of Nutrition for Employee Health
4. Personalized Live on-Demand Yoga Avatar Gains Popularity Amongst Users, Across all age Groups
5. Small Nutritional Changes are a Key to Health, Weight Loss, says DSM Personalized Nutrition
6. TGen Drug Development partners with Horizon Discovery for integrated personalized medicine service
7. Personalized medicine for cancer patients in a new technology era
8. Pediatric personalized medicine takes center stage at first-of-its-kind international conference
9. DSM Personalized Nutrition Webinar Examines Ways to Build Engagement in Wellness Programs
10. Myth Debunked: Baby Shower Gifts CAN Be Personalized Without Knowing Name Or Gender
11. Advances in personalized medicine take center stage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 (HealthDay News) -- As gas prices rose in ... new study suggests. In times of gas increases, ... riders are inexperienced, the researchers explained. They examined ... has the highest number of motorcycle registrations in the ... deaths. The analysis revealed a strong association between ...
(Date:12/17/2014)... -- Poor students get more fruits and vegetables at school ... But, the opposite is true for students from wealthier families. ... school may give a healthy boost to poor students, diets, ... family income level, students all ate a similar amount of ... study was published recently in the journal Preventive Medicine ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. ... to improve overall health, but a growing body of evidence ... new review finds. In fact, the benefits were similar ... lead researcher Paula Chu, a doctoral candidate at Harvard University,s ... clinical trials, found that people randomly assigned to take yoga ...
(Date:12/15/2014)... December 15, 2014 Cancer researchers have ... underlying genetic causes of deadly malignant pleural mesothelioma. Surviving ... on their website. Click here to read it ... of Hawaii Cancer Center, and New York’s Langone Medical ... pleural mesothelioma patients in an effort to pinpoint ...
(Date:12/15/2014)... 2014 South Florida’s leading urgent care provider, ... be a daze of hassle, hustle, and bustle that can ... halls, to burns when making special meals and heartburn after ... happen at any time. To prevent this season of joy ... a list of helpful and healthful holiday tips to keep ...
Breaking Medicine News(10 mins):Health News:When Gas Prices Go Up, So Do Motorcycle Accidents, Study Finds 2Health News:Poor Students Eat Healthier Foods at School, Study Finds 2Health News:Yoga May Cut Heart Disease Risk Factors 2Health News:Yoga May Cut Heart Disease Risk Factors 3Health News:New Study Reveals Genetic Mutations That May Trigger Mesothelioma, According to Surviving Mesothelioma 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3
... tertiary healthcare infrastructure and provide quality medical education, the ... a cost of Rs.15.6 billion, it was announced Thursday. ... the Cabinet Committee on Economic Affairs chaired by Prime ... like Jammu and Kashmir, Uttar Pradesh and Jharkhand. ...
... the country today called for mass screening to identify people ... a national stroke prevention policy. // ,On the ... bust popular myths about strokes -- widely and wrongly believed ... , ,"Unlike heart attacks, people know very little about ...
... in the AII India Institute of Medical Sciences (AIIMS) here ... ,The blaze broke out in the X-ray department ... after 1 a.M., they said., ,Fifteen fire tenders were ... control after around two hours., ,The X-ray wing was ...
... special health care needs (CSHCN) and their family members ... addition, the poorer children have decreased chances of having ... are the two most important results, sourced from a ... researchers, published in the June 2006 issue of the ...
... has revealed that PMS, menopause and post natal depression are ... ,Research has revealed that although there are physiological ... syndrome (PMS), menopause and post natal depression (PND) are primarily ... psychology at the University of Western Sydney, Jane Ussher has ...
... Ulster Hospital were been faced by the doctors – a ... study by the BMA in Northern Ireland, say a similar ... been found. A postal questionnaire addressed to all BMA workers ... ,More than half doctors participated in the survey ...
Cached Medicine News:Health News:Health Care For Children With Special Needs Compromised 2
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/ms3j8c/cardiac ) has announced the addition of the ... 2012-2018"  report to their offering. Global Guidewires sector ... North America accounts for nearly ... Europe claims approximately 25% (2018). ...
(Date:12/15/2014)... Israel , Dec. 15, 2014  Immune ... announced today that its Board of Directors has elected Mr. ... Teper who continues as Chief Executive Officer of Immune. ... Directors since 2013. Immune,s new Chairman, Mr. ... interest of shareholders and to continue to support the strategic ...
(Date:12/15/2014)... N.J. , Dec. 15, 2014   Regeneron ... and NYSE: SNY) are collaborating with nationally-recognized patient and ... , an awareness program that will gauge how much ... associated with high LDL-C (bad cholesterol).  American adults are ... take a brief poll and answer a few key ...
Breaking Medicine Technology:Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 2Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 3Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 4Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6
... Trubion Pharmaceuticals, Inc. (Nasdaq: TRBN ), today announced it ... BIO Investor Forum to be held at the Palace Hotel ... officer and chairman of the board of directors, is scheduled ... 29 at 1:30 p.m. PDT. The presentation will be available ...
... 26 Shopko is pleased to announce the promotion of ... Apparel and Accessories. He will have primary responsibility for all ... marketing plans. , Csuy joined Shopko in the position ... added Men,s apparel to his responsibilities in December 2008. , ...
Cached Medicine Technology:Trubion Announces Upcoming Presentation at 8th Annual BIO Investor Forum 2Csuy Named Senior Vice President/General Merchandise Manager 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: