Navigation Links
Personalized treatment may help some liver cancer patients
Date:10/22/2010

A more personalized treatment for people with a type of metastatic liver cancer --hepatocellular carcinoma -- may be possible by targeting the protein c-Met, according to Penn State College of Medicine researchers. Hepatocellular carcinoma (HCC) is the number three cause of cancer deaths in the world.

Hanning You, M.D., Ph.D., postdoctoral fellow, and C. Bart Rountree, M.D., assistant professor of pediatrics and pharmacology, targeted c-Met, a known receptor for hepatocyte growth factor, the substance that appears to drive liver cancer metastasis. In a pre-clinical translational study, they show that c-Met is overexpressed in metastatic liver cancer cells and is associated with a poor prognosis.

"In addition to finding that c-Met is a significant biomarker for liver cancer, we conducted an analysis of six published manuscripts and 1,051 patients," said You. "Through this analysis we demonstrated and confirmed that c-Met activation is strongly associated with poor prognosis and aggressive features in patients with liver cancer tumors."

Currently, physicians treat hepatocellular carcinoma with a "one size fits all" approach, so targeting c-Met may be an effective therapy for some patients.

"The five-year-survival of HCC is only 2 percent when diagnosed after metastasis," said Rountree. "Sorafenib, the most recently approved mediation for advanced HCC, benefits patients with an extra two months survival."

By targeting c-Met, researchers suppressed tumor growth and proliferation in a mouse model. They believe that molecular profiling will allow better treatment for the 45 percent of HCC patients who have c-Met positive tumors.

The research team is now looking to apply their findings to HCC in humans. The lab has applied to the National Cancer Institute to join a phase I trial using a c-Met inhibitor for advanced HCC.

"We are also working to build a second trial where we will establish a molecular profile of HCC patients before we start treatment, and then only give the c-Met inhibitor to the patients with a c-Met positive tumor, in effect personalizing their therapy," Rountree said.


'/>"/>

Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Related medicine news :

1. Perspectives on improving patient care: Genetics, personalized medicine, and behavioral intervention
2. Penn receives $12 million NIH grant to research personalized approach to smoking cessation
3. Personalized medicine: Molecular imaging predicts treatment success in many cancers
4. Pilot study supports adolescent diabetes patients through personalized text messages
5. Tumor target suggests personalized treatment for melanoma
6. Advances in personalized medicine take center stage
7. Myth Debunked: Baby Shower Gifts CAN Be Personalized Without Knowing Name Or Gender
8. DSM Personalized Nutrition Webinar Examines Ways to Build Engagement in Wellness Programs
9. Pediatric personalized medicine takes center stage at first-of-its-kind international conference
10. Personalized medicine for cancer patients in a new technology era
11. TGen Drug Development partners with Horizon Discovery for integrated personalized medicine service
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Today, ... optimize the ingestion of their medication by matching users with high quality water pipes ... compare pieces with no commitment. , Inhale was founded by two brothers, Nick and ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Blood Supply Foundation, a not-for-profit organization responsible for clinical transfusion research programs and ... enrollment for the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) study. ...
(Date:6/23/2016)... TX (PRWEB) , ... June 23, 2016 , ... The ... and business clients throughout Jasper County and the surrounding region, is initiating a charity ... charity drive will raise funds earmarked for a scholarship fund that will be presented ...
(Date:6/23/2016)... ... 23, 2016 , ... Representatives of CHA Fertility Centers (CFC), one of the ... Dr. Joshua J. Berger. As of May 2016, Dr. Berger will serve as ... Berger has received recognition for his research, his teaching and his patient care. After ...
(Date:6/23/2016)... ... June 23, 2016 , ... The U.S. Supreme Court decision on immigration ... by The Senior Citizens League (TSCL) . “President Obama’s executive actions on ... for people who worked in this country illegally, even though the newly - issued ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
(Date:6/23/2016)... 23, 2016 The Biotechnology industry ... to present great opportunities to investors. Stock-Callers.com assesses the ... Corp. (NYSE: XON ), Vertex Pharmaceuticals Inc. ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... and receive your complimentary trade alerts at: ...
(Date:6/23/2016)... 2016 Research and Markets has ... 2016 Edition: The New Global Agenda " report to ... Distribution in Europe - the 2016 ... tracks change. It identifies the driving factors coming into play ... healthcare industry now and in the future. It provides a ...
Breaking Medicine Technology: