Navigation Links
Personalized treatment may help some liver cancer patients
Date:10/22/2010

A more personalized treatment for people with a type of metastatic liver cancer --hepatocellular carcinoma -- may be possible by targeting the protein c-Met, according to Penn State College of Medicine researchers. Hepatocellular carcinoma (HCC) is the number three cause of cancer deaths in the world.

Hanning You, M.D., Ph.D., postdoctoral fellow, and C. Bart Rountree, M.D., assistant professor of pediatrics and pharmacology, targeted c-Met, a known receptor for hepatocyte growth factor, the substance that appears to drive liver cancer metastasis. In a pre-clinical translational study, they show that c-Met is overexpressed in metastatic liver cancer cells and is associated with a poor prognosis.

"In addition to finding that c-Met is a significant biomarker for liver cancer, we conducted an analysis of six published manuscripts and 1,051 patients," said You. "Through this analysis we demonstrated and confirmed that c-Met activation is strongly associated with poor prognosis and aggressive features in patients with liver cancer tumors."

Currently, physicians treat hepatocellular carcinoma with a "one size fits all" approach, so targeting c-Met may be an effective therapy for some patients.

"The five-year-survival of HCC is only 2 percent when diagnosed after metastasis," said Rountree. "Sorafenib, the most recently approved mediation for advanced HCC, benefits patients with an extra two months survival."

By targeting c-Met, researchers suppressed tumor growth and proliferation in a mouse model. They believe that molecular profiling will allow better treatment for the 45 percent of HCC patients who have c-Met positive tumors.

The research team is now looking to apply their findings to HCC in humans. The lab has applied to the National Cancer Institute to join a phase I trial using a c-Met inhibitor for advanced HCC.

"We are also working to build a second trial where we will establish a molecular profile of HCC patients before we
'/>"/>

Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Perspectives on improving patient care: Genetics, personalized medicine, and behavioral intervention
2. Penn receives $12 million NIH grant to research personalized approach to smoking cessation
3. Personalized medicine: Molecular imaging predicts treatment success in many cancers
4. Pilot study supports adolescent diabetes patients through personalized text messages
5. Tumor target suggests personalized treatment for melanoma
6. Advances in personalized medicine take center stage
7. Myth Debunked: Baby Shower Gifts CAN Be Personalized Without Knowing Name Or Gender
8. DSM Personalized Nutrition Webinar Examines Ways to Build Engagement in Wellness Programs
9. Pediatric personalized medicine takes center stage at first-of-its-kind international conference
10. Personalized medicine for cancer patients in a new technology era
11. TGen Drug Development partners with Horizon Discovery for integrated personalized medicine service
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... 2013 Pyramid Healthcare Solutions will showcase ... services at the National Cancer Registrars Association’s 39th Annual ... Hilton Union Square in San Francisco. The conference will ... registrars keep up-to-date with changes in the industry. ... numerous opportunities to gain perspectives from industry leaders through ...
(Date:5/23/2013)... 23, 2013 Combating street harassment ... tackled by the Safe Passage Committee in San Francisco’s ... safety workshop for women on Monday from Kidpower, ... skills programs for people of all ages. , "Women ... with street harassment for years,” said Dina Hilliard, Executive ...
(Date:5/23/2013)... 23, 2013 Jim Fitzpatrick just did ... Advertising developed yet another outside-of-the-box approach to reaching the ... he brings daily newscasts to the retail automotive industry, ... of a broadcast news format. , CBTNews.com is ... news. Co-anchors Bridget Everett and Russell Brown host the ...
(Date:5/23/2013)... A medical malpractice case which was ... 110504/2009) by Lori Mandel, an office manager in her ... million. Ms. Mandel sought the medical expertise of an ... complications that affected the quality of her life and ... alleged that her doctor rendered conservative treatment for 2 ...
(Date:5/23/2013)... in the brains of people affected by schizophrenia, ... Williamson, from Western University, to gain a better ... diseases. Dr. Williamson and colleagues have shown ... disrupted in different psychiatric diseases. These results ... the annual meeting of the Canadian Association for ...
Breaking Medicine News(10 mins):Health News:Pyramid Healthcare Solutions to Spotlight Its Cancer Registry Services at 2013 NCRA Conference 2Health News:Pyramid Healthcare Solutions to Spotlight Its Cancer Registry Services at 2013 NCRA Conference 3Health News:San Francisco Tenderloin Women Say “No!” to Street Harassment: Safe Passage Sponsors Kidpower Adult Safety Skills Workshops and Resources 2Health News:San Francisco Tenderloin Women Say “No!” to Street Harassment: Safe Passage Sponsors Kidpower Adult Safety Skills Workshops and Resources 3Health News:San Francisco Tenderloin Women Say “No!” to Street Harassment: Safe Passage Sponsors Kidpower Adult Safety Skills Workshops and Resources 4Health News:Fitzpatrick Advertising Founder Brings Auto Industry into Focus with CBT News 2Health News:New York Law Journal Releases Top Medical Malpractice Case for 2012: NY Supreme Court Awards $8.6 Million to Plaintiff after Doctor's Misdiagnosis Led to Personal Injury 2Health News:New York Law Journal Releases Top Medical Malpractice Case for 2012: NY Supreme Court Awards $8.6 Million to Plaintiff after Doctor's Misdiagnosis Led to Personal Injury 3Health News:Researchers identify networks of neurons in the brain that are disrupted in psychiatric disease 2
... Inc.,(Nasdaq: ITMN ) today announced that Steven Porter, ... the 2008 Wachovia Healthcare,Conference in Boston on January 31, ... live audio webcast of the presentation, investors and other,interested ... of InterMune,s,corporate website at http://www.intermune.com . The company ...
... William George and Secretary Treasurer Richard,Bloomingdale today expressed ... Joseph Pitts, and William Shuster to play,partisan politics ... hit hardest by our weakening economy., "It,s ... a severe economic downturn,Representatives Peterson, Pitts and Shuster ...
... Hospital, CHARLESTON, S.C., Jan. 23 In ... Tower, its new state-of-the-art hospital,patients and visitors will ... art on permanent display., (Photo: http://www.newscom.com/cgi-bin/prnh/20080123/CLW134 ... decades that art has an impact on,healing, but ...
... Assistant Attorney,General Alice S. Fisher of the Criminal ... Southern District of Florida announced today that,owners of ... to prison terms within the past two weeks. ... for $56,599,832 worth of,unnecessary durable medical equipment (DME) ...
... Boston Scientific (NYSE: BSX ),today issued the following ... Officer, on an article in the New England Journal ... for,Off-Label Indications.", "The analysis from the National Heart, ... England Journal of Medicine is the latest,in a series ...
... potential for repeat treatments to blame, study finds , , ... 5 percent more to treat people with peripheral arterial ... a U.S. study finds. , Both PAD (blocked abdomen ... treated with the same methods, including medication, surgery and ...
Cached Medicine News:Health News:InterMune to Present at the 2008 Wachovia Healthcare Conference 2Health News:Pennsylvania AFL-CIO Decries Shameful Votes Again by Representatives John Peterson, Joe Pitts and Bill Shuster, Against Children's Health Care 2Health News:Medical University of South Carolina (MUSC) and Halsey Institute Create Partnership Between Art and Science 2Health News:Nine Miami Defendants in Strike Force Cases Sentenced for $56.5 Million in Medicare Fraud 2Health News:Nine Miami Defendants in Strike Force Cases Sentenced for $56.5 Million in Medicare Fraud 3Health News:Nine Miami Defendants in Strike Force Cases Sentenced for $56.5 Million in Medicare Fraud 4Health News:Boston Scientific Comments on New England Journal of Medicine Article 2Health News:Boston Scientific Comments on New England Journal of Medicine Article 3Health News:Peripheral Arterial Disease Costlier to Treat Than Heart Trouble 2
(Date:5/22/2013)... WILMINGTON, Del. and MUNICH , ... venture-backed developer, manufacturer and marketer of transcatheter aortic valve implantation ... today its first interim results of the J enaValve ... Safety I n Pa T ients with S E ... Paris . JUPITER is a post-market registry ...
(Date:5/22/2013)... YORK , May 22, 2013  The Lupus ... conference devoted to advancing new treatments for lupus nephritis, ... 60 percent of patients. The conference launched a new ... the Lupus Nephritis Trials Network (LNTN). More ... and the kidney came together to focus on two ...
(Date:5/22/2013)... , May 22, 2013 The new 13-valent ... as the previous version used prior to 2010, the ... Permanente study published today in Vaccine. The ... beginning in 2010 after a series of trials. These ... range of pneumococcal types than the previously used PCV7, ...
Breaking Medicine Technology:First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 2First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 3First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 4Lupus Research Institute Hosts First International Conference to Advance New Treatments for Lupus Nephritis 2Kaiser Permanente Study Finds New Pneumococcal Vaccine Appears to be as Safe as Previously Used Vaccine 2Kaiser Permanente Study Finds New Pneumococcal Vaccine Appears to be as Safe as Previously Used Vaccine 3Kaiser Permanente Study Finds New Pneumococcal Vaccine Appears to be as Safe as Previously Used Vaccine 4
... , NEW YORK, Nov. 24 ... Ron Bentsur, the Company,s Chief Executive Officer, is scheduled to ... being held in New York City. , Mr. Bentsur,s presentation ... ET and will be accessible from the Investor Information page ...
... HealthWarehouse.com, Inc. (OTC Bulletin Board: HEWA) an online U.S. ... quarter ended September 30, 2009. The company reported quarterly revenue ... pharmacy transfers. Gross margins increased 13.0% year-over-year to 34.6% and ... a net loss of $186,299 for the three months ended ...
Cached Medicine Technology:Keryx Biopharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference 2HealthWarehouse.com, Inc. Announces Third Quarter Financial Results; Revenues, Margins, and Orders Shipped Increase Over Third Quarter 2008 2HealthWarehouse.com, Inc. Announces Third Quarter Financial Results; Revenues, Margins, and Orders Shipped Increase Over Third Quarter 2008 3
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Each handle is designed to fit a specific trephine size....
Each handle is designed to fit a specific trephine size....
Medicine Products: