Navigation Links
Personalized gene therapies may increase survival in brain cancer patients
Date:1/9/2012

ted genes influencing survival, but also took into consideration clinical factors such as age, race and gender.

"Our research suggests you can't treat all patients the same," Serao said. "For example, we found gene expression patterns that have different, and sometimes opposite, relationships with survival in males and females and concluded that treatments affecting these genes will not be equally effective. Personalized therapy dependent on gender, race and age is something that is possible today with our advanced genomic tools."

Recognizing that genes seldom act alone, this team of researchers took several genes into consideration at the same time and uncovered networks of genes related to glioblastoma survival.

Sandra Rodriguez Zas, co-researcher and U of I professor of animal science and bioinformatics, said they looked at commonalities between the genes linked to glioblastoma survival and progression, too.

"If a large number of genes linked to survival belong to a particular pathway, this pathway is considered enriched," Rodriguez Zas said. "Depending on whether the pathway and genes have tumor suppressor or oncogenic characteristics, we should be able to use that information to support or attack that pathway with targeted therapies."

Gaining a deeper understanding of the biological meaning, or roles, for these genes will provide researchers with even more ammunition to fight this deadly form of brain cancer.

"Because of the innovative approach we used, we believe we can more confidently predict whether a patient will have a shorter or longer survival rate and select the most adequate therapies," she said.

This study, "Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival," was published in BMC Medical Genomics. Researchers include Nicola Serao, Kristin Delfino, Bruce Southey, Jonathan Beever and Sandra Rodr
'/>"/>

Contact: Jennifer Shike
jshike@illinois.edu
217-244-0888
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New personalized treatment options for cancer
2. New book by University of Louisville professor enables reader to develop personalized anti-depression plan
3. Northwestern to explore personalized medicine for scleroderma
4. Tumor-targeting compound points the way to new personalized cancer treatments
5. New and varied imaging techniques facilitate personalized medicine
6. Matching targeted therapies to tumors specific gene mutations key to personalized cancer treatment
7. Breast milk may provide a personalized screen of breast cancer risk
8. WSU researcher creates patented personalized therapy that causes cancer cells to kill themselves
9. IU Personalized Medicine Institute to develop targeted and individualized treatments
10. Tufts University calls for moderate approach to teaching personalized genomic testing
11. Personalized molecular therapy shows promising results for people with advanced lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... occasion of the Leishmaniasis East Africa Platform meeting, ... leishmaniasis experts, results of a pharmacovigilance or ... carried out by MSF, DNDi, and national partners ... to key decision makers in order to boost ... combination of Sodium Stibogluconate and Paromomycin (SSG&PM) in ...
(Date:10/1/2014)... 01, 2014 October is national Breast ... early detection plans while raising money for breast cancer ... Cancer Awareness Month in the effort to find ... promote the importance of having access to clean, healthy ... be linked to certain forms of cancer. , ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Dr. Saj ... and prosthodontists, is traveling to Chennai, India, tomorrow ... on Oct. 2 and 3. , Dr. Jivraj is ... Hills and Oxnard, Calif., and one of the world’s ... restoration and replacement. He is speaking to the Indian ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Two bicyclists ... take them across the country in an effort to ... military families. The cyclists, a father-daughter team, plan ... beginning in Blaine, Washington and finishing in Key West ... Hope For The Warriors®, a national nonprofit organization that ...
(Date:10/1/2014)... 01, 2014 After undergoing a trial-and-error ... of commerce to join, Living Well Assisted Living at ... in Marin County, the home of its headquarters. , ... moment, and the thought of adding one more activity ... keep looking for the right chamber to join because ...
Breaking Medicine News(10 mins):Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:Pelican Water Supports Breast Cancer Awareness Month with Order Donations 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 3Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 4Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 5Health News:Father-Daughter Cycling Duo to Ride Cross-Country to Benefit Hope For The Warriors 2Health News:Living Well Joins San Rafael Chamber of Commerce 2Health News:Living Well Joins San Rafael Chamber of Commerce 3
... at the Congressional Gold Medal ceremony in the Capitol ... Below are the,Speaker,s remarks:, "Good morning. It is ... the House and Senate to honor Dr. Michael DeBakey. ... Representative Al,Green, and others who worked with them for ...
... CHAPEL HILL, N.C., April 23 Global leaders ... as a powerful tool for competing in today,s ... firm Best Practices, LLC.,The study further reveals -- ... strategic process of transforming raw competitive data,into actionable ...
... Foundation (EGPAF), a world leader in the fight against ... totaling $1 million to researchers to support the development ... MD, PhD, professor of medicine at the University of ... Luzuriaga, MD, professor of pediatrics and director of the ...
... FDAnews and Industry Directions Launch New Study, ... FDAnews and Industry Directions Inc., in close,association with ... manufacturers to respond to a new survey on ... company objectives,business processes and practices, information systems and ...
... protein prevents inflammation, hints of new treatments for disease ... they may have discovered how tumors develop in the ... for gastric cancer. , In a study done on ... Ludwig Institute for Cancer Research (LICR) found that blocking ...
... (NYSE: RAI ) will webcast its conference call ... April 30,2008. The call will begin at 9:30 a.m. ... Reynolds American management team will,discuss RAI,s first-quarter results., ... a listen-only basis,at http://www.ReynoldsAmerican.com . Registration for the ...
Cached Medicine News:Health News:Pelosi: 'By Literally Fixing Broken Hearts, Dr. DeBakey Has Given Hope and Health to Millions' 2Health News:Complimentary Excerpt Available from Best Practices: Pharmaceutical Competitive Intelligence Excellence - Optimizing Data Collection within Approved Guidelines 2Health News:UMass Medical School researchers awarded pediatric HIV vaccine development grant 2Health News:UMass Medical School researchers awarded pediatric HIV vaccine development grant 3Health News:Risk Management: Best Practices for Medical Device Profitability 2Health News:Scientists Discover How Stomach Tumors Form 2Health News:RAI to Webcast First Quarter 2008 Earnings Conference Call 2
(Date:10/1/2014)... 2014   Cypher Genomics, Inc., the genome ... Patrick Ravenel as chief technology officer. Ravenel has ... experience and a proven track record of designing and ... "Patrick has been recognized as a top designer and ... known industry-wide for delivering innovative products that operate at ...
(Date:10/1/2014)...   Royal Philips (NYSE: ... and eCareCompanion telehealth applications have received 510(k) clearance ... A part of Philips Hospital to Home,s ... are focused on patient care within the home ... available through the cloud-based digital health platform, which ...
(Date:10/1/2014)... WOONSOCKET, R.I. , Oct. 1, 2014  CVS ... Pharmacists Month for their role in changing the way ... and improve quality in the Company,s retail pharmacies, mail ... "Last month, we changed our company name to CVS ... our expertise in driving the innovations needed to shape ...
Breaking Medicine Technology:Cypher Genomics Appoints J. Patrick Ravenel Chief Technology Officer 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 3Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 4CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 2CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 3
... (Pink Sheets: APHY ), a pharmacy service healthcare ... medication fulfillment solutions to sufferers of chronic pain, is pleased ... from an existing shareholder which can be converted in whole ... the holder,s option into a maximum of 500 shares of ...
... Sept. 14 ICAP Ocean Tomo , ... (IAP.L) and the world,s premier patent auction firm, ... detection and classification at the upcoming Fall ... 11th. (Logo:   http://photos.prnewswire.com/prnh/20100614/CG20517LOGO ) ...
Cached Medicine Technology:Assured Pharmacy Receives $500,000 in Debt Financing 2Assured Pharmacy Receives $500,000 in Debt Financing 3Skin Lesion Identification System to Auction on November 11th at ICAP Ocean Tomo's Fall 2010 Live IP Auction 2Skin Lesion Identification System to Auction on November 11th at ICAP Ocean Tomo's Fall 2010 Live IP Auction 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: