Navigation Links
Personalized gene therapies may increase survival in brain cancer patients
Date:1/9/2012

Personalized prognostic tools and gene-based therapies may improve the survival and quality of life of patients suffering from glioblastoma, an aggressive and deadly form of brain cancer, reports a new University of Illinois study funded by the NIH National Cancer Institute.

"We confirmed known biomarkers of glioblastoma survival and discovered new general and clinical-dependent gene profiles," said Nicola Serao, a U of I Ph.D. candidate in animal sciences with a focus in statistical genomics. "We were able to compare biomarkers across three glioblastoma phases that helped us gain insight into the roles of genes associated with cancer survival."

Glioblastoma is a complex, multifactorial disease that has swift and devastating consequences, Serao said. Although some genes have been associated with the presence of glioblastoma, few have been identified as prognostic biomarkers of glioblastoma survival and fewer have been confirmed in independent reports.

"You can't just find one gene that is related to this cancer and fix it," he said. "This is one of the aspects of our research that makes it unique. We were able to look at several genes at the same time and relate our findings to this cancer."

Using genomic information from more than 22,000 genes, Serao took this huge piece of information and began slicing away at it, one gene at a time, until he ended up with a group of genes related to brain cancer.

He studied different survival variables, including length of survival from birth to death, from diagnosis to death, and from diagnosis to progression of the cancer.

"We studied different variables, but they were complementary, and allowed us to learn more about those genes," he said. "We understand that some genes have much more impact in cancer than others. And we also discovered that some genes only appeared in one variable, so they were specific for a given phase of cancer."

This study not only evaluated genes influencing survival, but also took into consideration clinical factors such as age, race and gender.

"Our research suggests you can't treat all patients the same," Serao said. "For example, we found gene expression patterns that have different, and sometimes opposite, relationships with survival in males and females and concluded that treatments affecting these genes will not be equally effective. Personalized therapy dependent on gender, race and age is something that is possible today with our advanced genomic tools."

Recognizing that genes seldom act alone, this team of researchers took several genes into consideration at the same time and uncovered networks of genes related to glioblastoma survival.

Sandra Rodriguez Zas, co-researcher and U of I professor of animal science and bioinformatics, said they looked at commonalities between the genes linked to glioblastoma survival and progression, too.

"If a large number of genes linked to survival belong to a particular pathway, this pathway is considered enriched," Rodriguez Zas said. "Depending on whether the pathway and genes have tumor suppressor or oncogenic characteristics, we should be able to use that information to support or attack that pathway with targeted therapies."

Gaining a deeper understanding of the biological meaning, or roles, for these genes will provide researchers with even more ammunition to fight this deadly form of brain cancer.

"Because of the innovative approach we used, we believe we can more confidently predict whether a patient will have a shorter or longer survival rate and select the most adequate therapies," she said.

This study, "Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival," was published in BMC Medical Genomics. Researchers include Nicola Serao, Kristin Delfino, Bruce Southey, Jonathan Beever and Sandra Rodriguez Zas of the University of Illinois.


'/>"/>

Contact: Jennifer Shike
jshike@illinois.edu
217-244-0888
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Related medicine news :

1. New personalized treatment options for cancer
2. New book by University of Louisville professor enables reader to develop personalized anti-depression plan
3. Northwestern to explore personalized medicine for scleroderma
4. Tumor-targeting compound points the way to new personalized cancer treatments
5. New and varied imaging techniques facilitate personalized medicine
6. Matching targeted therapies to tumors specific gene mutations key to personalized cancer treatment
7. Breast milk may provide a personalized screen of breast cancer risk
8. WSU researcher creates patented personalized therapy that causes cancer cells to kill themselves
9. IU Personalized Medicine Institute to develop targeted and individualized treatments
10. Tufts University calls for moderate approach to teaching personalized genomic testing
11. Personalized molecular therapy shows promising results for people with advanced lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... February 13, 2016 , ... The National Association ... leading national organization representing the growing community of recovering individuals (now over 23 ... Family Recovery in policies addressing addiction. , Although many of the presidential ...
(Date:2/13/2016)... FL (PRWEB) , ... February 13, 2016 , ... The ... environmental impact of American businesses. , The increasingly modern world of instantaneous consumption ... often on non-renewable energy sources such as oil and coal, which pollutes our air, ...
(Date:2/13/2016)... ... ... an Au Pair comes all the way around the world to provide child ... are often worried things won’t go well. More often than not, however, they find out ... the Year winner’s all commented how their Au Pairs have become a part of the ...
(Date:2/12/2016)... ... , ... According to an article published February 4th on mySA, ... of hernia repairs throughout the United States. Commenting on this article, Beverly Hills hernia ... trend has not only been expected, but it seems to be a natural result ...
(Date:2/12/2016)... (PRWEB) , ... February 12, ... ... Foundation today announced a new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop the ... partnership will recruit top students from U.S. universities who will draw from ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016 /PRNewswire/ - Demers Ambulances announces its first delivery ... Okaloosa County Emergency Medical Services (EMS) ... and one LT2 van. Quality Emergency Vehicles in ... for the sale.  This is the latest in Demers, ongoing ... Vice President at Demers. --> Benoit LaFortune , ...
(Date:2/12/2016)... 2016  Memorial Hermann Health System has teamed up ... to bring a one-of-a-kind experience to pediatric patients at ... such as 360-degree video and Google Cardboard, Howard was ... – giving the patients and their families an unexpected, ... caught on video . Memorial Hermann ...
(Date:2/12/2016)... , Feb. 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ... announced the Company will ring the Nasdaq Closing Bell ... New York at 4:00 p.m. ET on ... Aralez. Adrian Adams , will perform ... 3:50 to 4:00 p.m. ET.  A live webcast will ...
Breaking Medicine Technology: