Navigation Links
Personal epigenetic 'signatures' found consistent in prostate cancer patients' metastases
Date:1/23/2013

etastatic sites in an individual patient. They identified more than 1,000 regions of the genome where various types of DNA methylation were consistently maintained within their 13 subjects' genomes.

"As they evolve and grow, cancer cells acquire and maintain changes that enable them to continue thriving," says Yegnasubramanian. "We know that cancer cells maintain and pass along genetic changes in the nucleus of cells across metastatic sites, and our research now shows that epigenetic changes also are maintained to nearly the same degree."

The scientists say that the consistent methylation changes they found appear to represent so-called driver changes critical to the cancer's development and could be targets for treatment. By contrast, other methylation changes found only sporadically in the metastatic sites are more likely what are called passenger changes that occur by chance and are less promising as treatment targets or biomarkers than driver changes.

"Our study shows that for prostate cancer, at least, each person develops his own path to cancer and metastasis, and we can find a signature of that path in the epigenetic marks within their tumors," says Yegnasubramanian, who envisions that certain epigenetic changes can be grouped into clusters to be used as biomarkers signaling a lethal cancer.

Yegnasubramanian and his team also plan to study how each of the driver changes work and how they influence cancer metastasis.


'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. PMD Healthcare Announces that Spiro PD Personal Spirometer May Help Increase Flu Vaccination Rates as Epidemic Surges
2. Understanding personality for decision-making, longevity, and mental health
3. Fitness Celebrity and one of Canada’s Inside Fitness Hot and Fit Women of 2012, Nancy Di Nino, brings her Media Personality to host the Hot & Fit Release Party
4. The Olive Oil Source Introduces Valentine’s Day Labels for Personalized Olive Oil and Vinegar Gifts
5. McGill University Launches a Major New Study on HPV Prevention Using Divine 9 Personal Lubricants with Carragel
6. PMD Healthcare Announces how Spiro PD Personal Spirometer Supports New Year’s Resolution to Exercise and Lose Weight, Complementing ACAAI Recommendations
7. Business Review Takes Notice of New Phone App "PumpUp" as a Personal Training Aid
8. Chemical Bank Conducts Personal Finance Classes for Passages Program at Eagle Village
9. Swimovate Watches Can Replace a Personal Swim Coach in the New Year Reports SwimovateUSA
10. Citizen's Bank Conducts Personal Banking Classes at Eagle Village
11. Dr. Steve Young Launches PSA on New Jersey Personal Trainers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... A new batteryless cardiac pacemaker based on an ... presented at ESC Congress 2014 today by Adrian ... require battery replacement. , Mr Zurbuchen, a PhD ... University of Bern, Switzerland, said: "Batteries are a ... reach a critically low energy level, physicians see ...
(Date:8/30/2014)... Malden, MA (PRWEB) August 31, 2014 In ... ‘dog eat dog’ approach, Karma Web Group, LLC launches a ... iOS and Android the newly launched Ultimate Karma app is ... rewarded with new levels of play, the game pulls double-duty ... at the same time. , Designed to reward gamers for ...
(Date:8/30/2014)... Atlanta, GA (PRWEB) August 31, 2014 ... across their dealerships to help raise money and awareness ... Bucket Challenge. , General Managers, staff, and even Vice ... was captured on film and can be viewed on ... to participating in the challenge, general managers and staff ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 The Truth about ... body that will reveal to users some shocking foods that ... great results in modeling looks, as well as some motivation ... method says that there is one unique trick that can ... indicates that despite what many people might think, cardio exercise ...
(Date:8/30/2014)... 2014 Ticket Down reports that ticket ... match next Saturday at Levi's Stadium. The summer months ... in the United States due to the fact that so many ... major city. Many of these games were practice games in ... summer. , Levi’s Stadium is a brand new facility that will ...
Breaking Medicine News(10 mins):Health News:Batteryless cardiac pacemaker is based on automatic wristwatch 2Health News:Newly Launched Ultimate Karma App Elicits Happiness in Players and Encourages Moral Values 2Health News:Jim Ellis Automotive Group Take the ALS Ice Bucket Challenge 2Health News:Truth about Six Pack Abs Review Reveals Unique Method to Eliminate Stubborn Stomach Fat 2Health News:Mexico vs. Chile Tickets at Levi's Stadium in Santa Clara, CA: TicketDown.com Offers Promo Code for Mexico vs. Chile Exhibition Game on September 6th 2
... Survey Reveals Favorite and Least Favorite Body Parts: ... Jan. 21 Faces and abs top the list ... both men and women, according to a new survey ... non-invasive aesthetic services in the U.S.Nearly a quarter of ...
... for 2009 , ... (Vocus) January 21, 2009 -- ... 2009 according to recent predictions made by the leadership of the ... prediction: a continued growth in consumers who elect to enhance ...
... Jan. 21 Senator Sam Brownback and Rep. ... Council,s Blogs for Life, on ... also feature several prominent conservative voices including Amanda ... Ph.D., Michael Illions, Peter Shinn, Chris Gacek, J.D., ...
... Health Plan Outperforms National Medicaid Plans on Key ... Health Plan (SFHP), the City,s community health plan, ... U.S. leader in childhood immunizations for Medicaid health ... are fully immunized, besting second-ranked Kaiser Permanente of ...
... have different reproductive plans, lifestyles, religious prohibitions, and ... contraceptive choices available, can make selecting the right ... of appropriate and acceptable contraceptive methods can improve ... pregnancy. To address this issue, OBG Management ...
... BALTIMORE, Jan. 21 Physicians Practice and Tucson Medical ... and their staff more time to devote to patient ... to help doctors in the southern Arizona area better ... busy practice. Through this new alliance, Tucson Medical Center ...
Cached Medicine News:Health News:How Does Our Vanity Fare? 2Health News:Cosmetic Injections A Worthwhile Investment 2Health News:Cosmetic Injections A Worthwhile Investment 3Health News:Cosmetic Injections A Worthwhile Investment 4Health News:Senator Sam Brownback and Rep. Cathy McMorris Rodgers to Speak at Blogs for Life 2009 2Health News:San Francisco Health Plan is U.S. Leader in Childhood Immunizations 2Health News:San Francisco Health Plan is U.S. Leader in Childhood Immunizations 3Health News:Physicians Practice and Tucson Medical Center Partner to Improve Patient Care in Southern Arizona 2Health News:Physicians Practice and Tucson Medical Center Partner to Improve Patient Care in Southern Arizona 3
(Date:8/29/2014)... Ore. , Aug. 29, 2014 /PRNewswire-iReach/ -- ... Accessory (Axilla) Strap for the SAM Junctional Tourniquet.  ... SAM Medical Products announced today ... voluntary recall to address a potential issue with ... used for the Axilla application of the SAM ...
(Date:8/29/2014)... PLEASANTON, Calif. , Aug. 29, 2014 ... leader in device-based mechanical circulatory support therapies to save, ... be participating in the 2014 Morgan Stanley Global Healthcare ... F. Burbach , President and Chief Executive Officer, will ... p.m., Eastern Daylight Time (9:55 a.m., Pacific Daylight Time). ...
(Date:8/29/2014)... , August 29, 2014 ... Oil Market by Extraction type (SFE, Cold Pressed, ... Personal Care, Pharmaceutical, Food Supplements, Fragrance, & Others) - ... MarketsandMarkets, defines and segments the Amaranth Seed Oil ... market size in terms of value. The Amaranth ...
Breaking Medicine Technology:SAM Medical Products Implements Voluntary Recall of its Accessory (Axilla) Strap for the SAM Junctional Tourniquet. 2Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4
... The two most,prevalent forms of genetic mental retardation, ... cause, according to researchers at,Stanford University School of ... brain, may also be associated with,autism., Although the ... result for the brain seems to be the ...
... YORK--(BUSINESS WIRE)--Apr 12, 2007 - INNOVIVE Pharmaceuticals,Inc. ... of INNO-406, a potent oral dual Bcr-Abl ... leukemia, will be presented at the American ... takes place April,14-18, 2007 at the Los ...
Cached Medicine Technology:Fragile X, Down Syndromes Linked to Faulty Brain Communication,Stanford Researcher Finds 2Fragile X, Down Syndromes Linked to Faulty Brain Communication,Stanford Researcher Finds 3Fragile X, Down Syndromes Linked to Faulty Brain Communication,Stanford Researcher Finds 4Innovive Pharmaceuticals Announces Additional Data Presentations at,American Association for Cancer Research Annual Meeting 2
... single-use products to promote safety for your ... catheter reduces cross-contamination and helps protect your ... because cleaning is eliminated, you have more ... water perfused manometric catheters for esophageal, anorectal ...
Esophageal Stylet for LATITUDE® Air-Charged Catheter...
Replacement Stopper for LATITUDE® Air-Charged Catheter...
Manometric Calibration System for LATITUDE® Air-Charged Catheter...
Medicine Products: