Navigation Links
Persistent bacterial infection exploits killing machinery of immune cells
Date:11/2/2008

A new study reveals an important and newly discovered pathway used by disease-causing bacteria to evade the host immune system and survive and grow within the very cells meant to destroy them. This discovery may lead to new treatments and vaccines for tuberculosis (TB) and certain other chronic bacterial and parasitic infections.

The research, supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is the work of the laboratories headed by Peter Murray, Ph.D., at St. Jude Children's Research Hospital in Memphis, Tenn., and Thomas Wynn, Ph.D., of the Laboratory of Parasitic Diseases at NIAID. Their findings appear in the November issue of Nature Immunology.

Clearing the body of disease-causing bacteria is the job of specialized white blood cells called macrophages. The word "macrophage" means "big eater" in Latin and that is just what these cells are--they gobble up cell debris, infected cells and disease-causing bacteria found in the body. To help them digest and destroy what they eat, macrophages make compounds that in most cases kill pathogens. One of these chemicals is the free radical nitric oxide (NO).

However, some harmful bacteria, known as intracellular pathogens, live inside cells and can even survive and replicate within macrophages, somehow inhibiting or escaping killing by NO. One natural NO inhibitor made by macrophages is the enzyme arginase. Arginase steals and degrades the material required to make NO, therefore limiting how much NO is made.

"The bacteria designed to live inside the cell are highly adapted to their environment," says Dr. Murray. "We wanted to determine just how intracellular bacteria were turning on the genes that make arginase, thereby controlling the expression of NO and escaping killing by macrophages."

The research team discovered that intracellular pathogens increase levels of arginase, thereby r
'/>"/>

Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. First evidence that prenatal exposure to famine may lead to persistent epigenetic changes
2. New Webcast Going for Gold to Educate on Importance of Healthy Diet In Persistent Chronic Pain Management
3. Study analyzed SYMBICORT in children with persistent asthma
4. Persistent Insomnia Leads to Depression in Young Adults
5. Study Analyzed Long-Term SYMBICORT(R) Use in Children With Persistent Asthma
6. Study identifies which men are likely to have persistent prostate cancer
7. Want to Raise a Fruit-and-Veggie Lover? Be Persistent
8. Meniscal damage and the development of persistent knee pain
9. Comment Regarding Congregation for the Doctrine of Faith Clarification Concerning Nutrition and Hydration for Patients in a Persistent Vegetative State
10. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
11. Bacterial peptide provides new insight into common tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... treat children with uncomplicated acute appendicitis is a reasonable ... fewer missed school days, according to a pilot study. ... Hospital and published online April 12 in the ... the first prospective study on nonoperative management of acute ... , Researchers enrolled 77 patients age 7 to 17 ...
(Date:4/14/2014)... 2014, Perth, Australia. Drug discovery company Proteomics International ... of a companion diagnostic (CDx) test with the ... The research team authenticated the panel of biomarkers ... samples. Seven biomarkers were validated at high stringency ... The mass spectrometry data was then cross-validated using ...
(Date:4/14/2014)... 2014) When it comes to the cost and ... Patients get the best care when they are treated ... extensive experience in their current job, according to a ... and Columbia Business School. The study was published in ... Applied Economics . , The review of more ...
(Date:4/13/2014)... STANFORD, Calif. A low-cost empowerment program for ... and sexual harassment of these girls, who live ... and are frequently attacked, a large new study ... Stanford University School of Medicine, Lucile Packard Children,s ... No Worldwide, validated the program,s effectiveness in combating ...
(Date:4/11/2014)... the processes that control brain cell production could pave ... brain-related disorders. , Scientists have gained new understanding of ... how and when nerve and brain cells are formed ... and keeps it healthy. Their findings could help explain ... which is a fundamental characteristic of many diseases including ...
Breaking Medicine News(10 mins):Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 2Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 3Health News:Longer nurse tenure on hospital units leads to higher quality care 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4
... Male high school athletes more likely to drink and fight ... News) -- When it comes to teaching healthy behaviors, boys, ... thought. , New research suggests that for teenage boys, participation ... and binge drinking. , Girls, on the other hand, ...
... Study finds medication works as well in certain people, ... -- People suffering from blocked renal arteries fare just ... by having the narrowed artery opened and a stent ... chronic kidney disease -- people with severe hypertension -- ...
... ... employment and networking portal for people with disabilities and renews its commitment to leading the ... ... recently passed a milestone, the one year anniversary of the launch on November 7, 2008 ...
... Announces VSO Support For Lung Cancer Legislation , ... all veterans today on Veterans Day and announces the ... veterans on lung cancer -- the leading cause of ... ) , LCA also announces that major ...
... Near 9% Unemployment Leaves More Idaho Families Struggling with ... , BOISE, Idaho, Nov. 11 As Idaho,s jobless ... the over 67,300 unemployed Idahoans finding themselves without employer benefits. ... is calling on Idaho,s Congressional delegation to set politics aside ...
... Nov. 11 Accelify is proud to announce the addition of ... of Development in the State of Florida and will also join ... Accelify, Sandra served for eight years as a member of the ... During her time in the Florida legislature, she personally sponsored ...
Cached Medicine News:Health News:Boys' Team Sports May Encourage Bad Behavior 2Health News:Boys' Team Sports May Encourage Bad Behavior 3Health News:Surgery Not Always Best for Narrowed Kidney Arteries 2Health News:Surgery Not Always Best for Narrowed Kidney Arteries 3Health News:GettingHired.com Recognizes First Year Anniversary, Renews Commitment to Helping Lead the Effort to Reduce Employment Participation Gap for People with Disabilities 2Health News:GettingHired.com Recognizes First Year Anniversary, Renews Commitment to Helping Lead the Effort to Reduce Employment Participation Gap for People with Disabilities 3Health News:Lung Cancer Alliance Salutes Veterans 2Health News:Idaho's Rising Jobless Rate Fuels State's Growing Health Care Woes 2Health News:Accelify Announces the Addition of Sandra L. Murman to its National Board of Advisors 2Health News:Accelify Announces the Addition of Sandra L. Murman to its National Board of Advisors 3
(Date:1/15/2014)... Mass. , Jan. 15, 2014  Zafgen, ... the unmet needs of severely obese patients, today ... of beloranib, a selective inhibitor of methionine aminopeptidase ... a severe form of genetic obesity.  These results ... body composition, including reductions in body fat content ...
(Date:1/14/2014)... The Brandeis Medical Center, led by Dr. ... a premier and affordable laser tattoo removal experience with the ... Brandeis, focus is in providing high quality cosmetic services with ... all patients. " Southern California ... regret and patients seeking removal for those unwanted tattoos," said ...
(Date:1/14/2014)... NineSigma , Inc., the leading innovation ... Leadership Summit , May 14-16, 2014 at the Global ... . This is the premier ... breakthrough achievements through open innovation. Participants will learn how ... disciplines and even across industries. NineSigma ...
Breaking Medicine Technology:Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... TC-PLUS Solution tricompartmental total knee prosthesis stems ... arthroplasty. State-of-the-art design and manufacturing technologies have ... biomechanical function as well as a favorable ... insert to keep wear to a minimum. ...
... The TC-PLUS Solution tricompartmental total knee prosthesis ... knee arthroplasty. State-of-the-art design and manufacturing technologies ... optimum biomechanical function as well as a ... tibial insert to keep wear to a ...
... Knee System is a long term, quality ... Available in both posterior stabilized and anatomically ... System provides the flexibility needed to address ... ease of identification keeps the user in ...
... a long term, quality solution based on ... posterior stabilized and anatomically correct cruciate retaining ... flexibility needed to address patients' needs. In ... keeps the user in mind and promotes ...
Medicine Products: