Navigation Links
Permanent AF doubles risk of stroke compared to paroxysmal AF
Date:9/1/2014

Barcelona, Spain Monday 1 September 2014: Permanent atrial fibrillation (AF) doubles the risk of stroke compared to paroxysmal AF, according to research in more than 6 000 patients presented at ESC Congress today by Dr Thomas Vanassche from Belgium. The findings suggest that a simple clinical assessment of the type of AF can help doctors to better estimate stroke risk.

Ischaemic stroke is the second cause of death in the EU, accounting for over a million deaths and many more disabled patients each year. Annual direct health care costs amount to more than 20 billion. AF is a frequent rhythm disorder and an important risk factor for stroke (1). The presentation of AF can vary from short and often self-limiting episodes of arrhythmia in people with otherwise normal heart rhythm, called paroxysmal AF, to a continuously abnormal rhythm called permanent AF (2).

Dr Vanassche said: "Our study shows that the risk of stroke is higher in patients in whom the arrhythmia is present permanently, compared to patients who only have short episodes of arrhythmia, even when correcting for other stroke risk factors. Although it may seem intuitive that the continuous presence of AF carries a higher stroke risk than short, intermittent episodes, this has been an area of controversy."

He added: "Although some recent trials have reported higher stroke rates in patients with permanent compared with paroxysmal AF, other studies did not report a significant difference. Current guidelines recommend that the pattern of AF should not be taken into account when assessing the stroke risk in patients with AF, suggesting that, when it comes to stroke risk, 'any AF is AF'."

To address this question, the researchers pooled data from two previously conducted clinical trials, ACTIVE-A and AVERROES, for a combined sample size of more than 6 000 patients with AF. Besides the large number of patients, another important strength of the analysis was that none of the patients were treated with anticoagulant medication, which reduces the risk of stroke. In contrast to population studies, where it can be difficult to detect and verify all strokes, all events in the trial were rigorously detected and adjudicated.

The researchers found that patients with permanent AF had an almost twofold higher risk of stroke compared to patients with paroxysmal AF, with a yearly rate of 4.2% compared to 2.1%.

Dr Vanassche said: "Other studies have shown that patients with permanent AF are often younger and at a lower risk of stroke compared to those with permanent AF, and these findings were confirmed in our analysis. Nevertheless, the difference in risk of stroke remained significant when correcting for other risk factors such as age, heart failure, diabetes, sex, prior stroke, hypertension, and peripheral artery disease."

He added: "The higher risk of permanent versus paroxysmal AF was also seen when considering patients with low, intermediate, or high risk of stroke separately."

Dr Vanassche continued: "It is very important to acknowledge that regardless of its form and presentation, AF increased the risk of stroke. Therefore, all patients with AF should be assessed for risk, and if the risk is sufficiently high, they should be treated with anticoagulants. Thus, our results strengthen the existing recommendations."

He concluded: "On the other hand, these results do provide support for the intuitive notion that 'a lot of AF' carries more risk than 'a little AF'. In cases where there is doubt about whether a patient would benefit from anticoagulant therapy, the presentation of AF could be one of the additional factors to take into account."


'/>"/>

Contact: ESC Press Office
press@escardio.org
34-670-521-210
European Society of Cardiology
Source:Eurekalert  

Related medicine news :

1. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation
2. Shaft Medical San Diego Now Offers Viridis Derma KTP Laser to Permanently Remove Unwanted Spider Veins
3. Removing Skin Tags - How “Moles Warts Removal” Can Teach People Remove Skin Tags Permanently - Health Review Center
4. Year’s Recap Includes Office Relocation and Awards for Permanent Makeup Doctor
5. Kaiser Permanente study: Change in PSA levels over time can help predict aggressive prostate cancer
6. Montreal's Pestroy Now Able to Get Rid of Pests Permanently Without the Use of Pesticides
7. Remedies For Heartburn
8. How Heartburn No More Can Help People Treat Acid Reflux Permanently - Tony Nguyen
9. "I feel like a woman again." -- Ruth Swissa Has Created a Product that Temporarily and Permanently Restores Women's Sense of Self
10. Sufferers of a Brachial Plexus Injury Run the Risk of Permanent Damage
11. Home Remedies For Yeast Infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Permanent AF doubles risk of stroke compared to paroxysmal AF
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... MOUNTAIN VIEW, Calif. , June 23, 2016 ... 9:00 a.m. CST on Thursday, July 7, 2016 , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  ... Sciences, Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, ... The global pharmaceutical industry is witnessing ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate ... in Latin America . ... ... ... ...
Breaking Medicine Technology: