Navigation Links
Permanent AF doubles risk of stroke compared to paroxysmal AF

Barcelona, Spain Monday 1 September 2014: Permanent atrial fibrillation (AF) doubles the risk of stroke compared to paroxysmal AF, according to research in more than 6 000 patients presented at ESC Congress today by Dr Thomas Vanassche from Belgium. The findings suggest that a simple clinical assessment of the type of AF can help doctors to better estimate stroke risk.

Ischaemic stroke is the second cause of death in the EU, accounting for over a million deaths and many more disabled patients each year. Annual direct health care costs amount to more than 20 billion. AF is a frequent rhythm disorder and an important risk factor for stroke (1). The presentation of AF can vary from short and often self-limiting episodes of arrhythmia in people with otherwise normal heart rhythm, called paroxysmal AF, to a continuously abnormal rhythm called permanent AF (2).

Dr Vanassche said: "Our study shows that the risk of stroke is higher in patients in whom the arrhythmia is present permanently, compared to patients who only have short episodes of arrhythmia, even when correcting for other stroke risk factors. Although it may seem intuitive that the continuous presence of AF carries a higher stroke risk than short, intermittent episodes, this has been an area of controversy."

He added: "Although some recent trials have reported higher stroke rates in patients with permanent compared with paroxysmal AF, other studies did not report a significant difference. Current guidelines recommend that the pattern of AF should not be taken into account when assessing the stroke risk in patients with AF, suggesting that, when it comes to stroke risk, 'any AF is AF'."

To address this question, the researchers pooled data from two previously conducted clinical trials, ACTIVE-A and AVERROES, for a combined sample size of more than 6 000 patients with AF. Besides the large number of patients, another important strength of the analysis was that none of the patients were treated with anticoagulant medication, which reduces the risk of stroke. In contrast to population studies, where it can be difficult to detect and verify all strokes, all events in the trial were rigorously detected and adjudicated.

The researchers found that patients with permanent AF had an almost twofold higher risk of stroke compared to patients with paroxysmal AF, with a yearly rate of 4.2% compared to 2.1%.

Dr Vanassche said: "Other studies have shown that patients with permanent AF are often younger and at a lower risk of stroke compared to those with permanent AF, and these findings were confirmed in our analysis. Nevertheless, the difference in risk of stroke remained significant when correcting for other risk factors such as age, heart failure, diabetes, sex, prior stroke, hypertension, and peripheral artery disease."

He added: "The higher risk of permanent versus paroxysmal AF was also seen when considering patients with low, intermediate, or high risk of stroke separately."

Dr Vanassche continued: "It is very important to acknowledge that regardless of its form and presentation, AF increased the risk of stroke. Therefore, all patients with AF should be assessed for risk, and if the risk is sufficiently high, they should be treated with anticoagulants. Thus, our results strengthen the existing recommendations."

He concluded: "On the other hand, these results do provide support for the intuitive notion that 'a lot of AF' carries more risk than 'a little AF'. In cases where there is doubt about whether a patient would benefit from anticoagulant therapy, the presentation of AF could be one of the additional factors to take into account."


Contact: ESC Press Office
European Society of Cardiology

Related medicine news :

1. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation
2. Shaft Medical San Diego Now Offers Viridis Derma KTP Laser to Permanently Remove Unwanted Spider Veins
3. Removing Skin Tags - How “Moles Warts Removal” Can Teach People Remove Skin Tags Permanently - Health Review Center
4. Year’s Recap Includes Office Relocation and Awards for Permanent Makeup Doctor
5. Kaiser Permanente study: Change in PSA levels over time can help predict aggressive prostate cancer
6. Montreal's Pestroy Now Able to Get Rid of Pests Permanently Without the Use of Pesticides
7. Remedies For Heartburn
8. How Heartburn No More Can Help People Treat Acid Reflux Permanently - Tony Nguyen
9. "I feel like a woman again." -- Ruth Swissa Has Created a Product that Temporarily and Permanently Restores Women's Sense of Self
10. Sufferers of a Brachial Plexus Injury Run the Risk of Permanent Damage
11. Home Remedies For Yeast Infection
Post Your Comments:
Related Image:
Permanent AF doubles risk of stroke compared to paroxysmal AF
(Date:11/30/2015)... ... November 30, 2015 , ... A novel class ... could be effective in fighting methicillin-resistant Staphylococcus aureus (MRSA), one of the major ... showed that small molecule analogs that target the functions of SecA, a central ...
(Date:11/30/2015)... ... , ... Using a combination of two blood sugar tests rather than a ... a new study by researchers at the School of Public Health at Georgia State ... of Blood Glucose Tests ,” published in Frontiers in Public Health, the researchers noted ...
(Date:11/30/2015)... ... November 30, 2015 , ... International telepathology ... UPMC and KingMed Diagnostics researchers. Their review of more than ... with UPMC pathologists resulted in significantly altered treatment plans for more than half ...
(Date:11/30/2015)... ... November 30, 2015 , ... The Foundation for Breast and ... prevention—is joining forces with the award-winning creator and writer of Downton Abbey Julian ... 2015 at the Union League of Philadelphia. , The benefit, titled “An ...
(Date:11/30/2015)... ... November 30, 2015 , ... California-based i2i ... years, announced today that Michigan-based Family Health Center (FHC) has selected i2iTracks as ... years, FHC was awarded the largest Affordable Care Act grant for Federally Qualified ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... -- --> --> According ... Product (Soft Tissue, All Tissue, Dental Welding Lasers), Application (Conservative ... - Global Forecast to 2020", published by MarketsandMarkets, is expected ... of 5.2% during the forecast period from 2015 to 2020. ... Figures spread through 167 P ages and in-depth TOC ...
(Date:11/30/2015)... and ST. LOUIS , Nov. ... (NASDAQ: ESRX ) today announced an early renewal ... which began in 1999, will now extend through at ... --> After evaluating pharmacy benefit manager capabilities during ... Express Scripts continues to offer the best health plan ...
(Date:11/30/2015)... , Nov. 30, 2015 Booth #4303 – ... VAR ) will exhibit a broader array of products in ... Radiological Society of North America in ... at the meeting will feature X-ray components "At the Heart ... a line of products from Varian,s Claymount brand, and computer-aided ...
Breaking Medicine Technology: