Navigation Links
Permanent AF doubles risk of stroke compared to paroxysmal AF
Date:9/1/2014

Barcelona, Spain Monday 1 September 2014: Permanent atrial fibrillation (AF) doubles the risk of stroke compared to paroxysmal AF, according to research in more than 6 000 patients presented at ESC Congress today by Dr Thomas Vanassche from Belgium. The findings suggest that a simple clinical assessment of the type of AF can help doctors to better estimate stroke risk.

Ischaemic stroke is the second cause of death in the EU, accounting for over a million deaths and many more disabled patients each year. Annual direct health care costs amount to more than 20 billion. AF is a frequent rhythm disorder and an important risk factor for stroke (1). The presentation of AF can vary from short and often self-limiting episodes of arrhythmia in people with otherwise normal heart rhythm, called paroxysmal AF, to a continuously abnormal rhythm called permanent AF (2).

Dr Vanassche said: "Our study shows that the risk of stroke is higher in patients in whom the arrhythmia is present permanently, compared to patients who only have short episodes of arrhythmia, even when correcting for other stroke risk factors. Although it may seem intuitive that the continuous presence of AF carries a higher stroke risk than short, intermittent episodes, this has been an area of controversy."

He added: "Although some recent trials have reported higher stroke rates in patients with permanent compared with paroxysmal AF, other studies did not report a significant difference. Current guidelines recommend that the pattern of AF should not be taken into account when assessing the stroke risk in patients with AF, suggesting that, when it comes to stroke risk, 'any AF is AF'."

To address this question, the researchers pooled data from two previously conducted clinical trials, ACTIVE-A and AVERROES, for a combined sample size of more than 6 000 patients with AF. Besides the large number of patients, another important strength of the analysis was that none of the patients were treated with anticoagulant medication, which reduces the risk of stroke. In contrast to population studies, where it can be difficult to detect and verify all strokes, all events in the trial were rigorously detected and adjudicated.

The researchers found that patients with permanent AF had an almost twofold higher risk of stroke compared to patients with paroxysmal AF, with a yearly rate of 4.2% compared to 2.1%.

Dr Vanassche said: "Other studies have shown that patients with permanent AF are often younger and at a lower risk of stroke compared to those with permanent AF, and these findings were confirmed in our analysis. Nevertheless, the difference in risk of stroke remained significant when correcting for other risk factors such as age, heart failure, diabetes, sex, prior stroke, hypertension, and peripheral artery disease."

He added: "The higher risk of permanent versus paroxysmal AF was also seen when considering patients with low, intermediate, or high risk of stroke separately."

Dr Vanassche continued: "It is very important to acknowledge that regardless of its form and presentation, AF increased the risk of stroke. Therefore, all patients with AF should be assessed for risk, and if the risk is sufficiently high, they should be treated with anticoagulants. Thus, our results strengthen the existing recommendations."

He concluded: "On the other hand, these results do provide support for the intuitive notion that 'a lot of AF' carries more risk than 'a little AF'. In cases where there is doubt about whether a patient would benefit from anticoagulant therapy, the presentation of AF could be one of the additional factors to take into account."


'/>"/>

Contact: ESC Press Office
press@escardio.org
34-670-521-210
European Society of Cardiology
Source:Eurekalert  

Related medicine news :

1. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation
2. Shaft Medical San Diego Now Offers Viridis Derma KTP Laser to Permanently Remove Unwanted Spider Veins
3. Removing Skin Tags - How “Moles Warts Removal” Can Teach People Remove Skin Tags Permanently - Health Review Center
4. Year’s Recap Includes Office Relocation and Awards for Permanent Makeup Doctor
5. Kaiser Permanente study: Change in PSA levels over time can help predict aggressive prostate cancer
6. Montreal's Pestroy Now Able to Get Rid of Pests Permanently Without the Use of Pesticides
7. Remedies For Heartburn
8. How Heartburn No More Can Help People Treat Acid Reflux Permanently - Tony Nguyen
9. "I feel like a woman again." -- Ruth Swissa Has Created a Product that Temporarily and Permanently Restores Women's Sense of Self
10. Sufferers of a Brachial Plexus Injury Run the Risk of Permanent Damage
11. Home Remedies For Yeast Infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Permanent AF doubles risk of stroke compared to paroxysmal AF
(Date:4/29/2016)... ... April 29, 2016 , ... A new ... with severe congenital diaphragmatic hernia have better survival rates if surgery is performed ... (CDH)—a condition where the diaphragm fails to form completely, letting abdominal organs into ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... won the $30,000 Perlman Grand Prize of the 2016 Wharton Business Plan ... the Michelson People’s Choice Award, and the Committee Award for Most ‘Wow Factor,’ ...
(Date:4/29/2016)... NY (PRWEB) , ... April 29, 2016 , ... ... and engineer of patented products, announces the Gyrociser, an exercise invention which aids ... worth $2 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:4/29/2016)... ... April 29, 2016 , ... Melanoma is the deadliest type of skin cancer. Although only about ... of skin cancer deaths. More than 10,000 people are expected to die of melanoma this ... it is the one of the most commonly diagnosed cancers in young women. A recent ...
(Date:4/29/2016)... ... , ... New York City based oral and maxillofacial surgeon Dr. Majid Jamali is ... treat obstructive sleep apnea. Dr. Jamali is proud to offer this permanent solution to patients ... or both jaw bones. This surgery is performed to correct the alignment of the jaw. ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... April 28, 2016 New ... 2016" is a report that provides an overview ... R&D pipelines by identifying new targets and MOAs ... Company Profiles discussed in this H1 2016 Osteoarthritis ... Srl, AbbVie Inc., Abiogen Pharma S.p.A., Ablynx NV, ...
(Date:4/27/2016)... 2016 Im ... Zürich gab Strekin AG den Start einer ... Erhaltung des Resthörvermögens von Patienten, denen ein ... umfassende Phase-II-Doppelblindstudie mit Placebo-Kontrollgruppe werden momentan Patienten ... während der Operation direkt ins Mittelohr verabreicht. ...
(Date:4/27/2016)... , April 27, 2016 ... Including 42% Growth in Recurring Consumable Sales  ... Mauna Kea Technologies (Euronext: MKEA, OTCQX: MKEAY) inventor ... announced its sales for the first quarter ended March ... and the execution of its commercial strategy. ...
Breaking Medicine Technology: