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Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform
Date:6/24/2009

-- New Claims Cover Use of Phosphatidylserine-Targeting Antibodies to Image Solid Tumors and Other Malignancies --

-- Supported by Published Data Showing Utility of PS-Targeting Antibodies for the Molecular Imaging of Cancer --

TUSTIN, Calif., June 24 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM) today reported the issuance of a U.S. patent with broad claims covering vascular imaging applications for phosphatidylserine (PS)-targeting antibodies. The patent represents the first broad coverage of imaging claims under Peregrine's PS-targeting platform, which includes Peregrine's lead antibody bavituximab. PS is a phospholipid that becomes exposed on the surface of tumor blood vessel cells. Since PS is typically not exposed on the surface of normal tissues, it represents a unique target for the vascular imaging of tumors and tumor metastases in patients with cancer.

"PS-targeting antibodies such as bavituximab preferentially bind to tumor blood vessels, which makes them ideal vehicles for imaging the tumor vasculature," said Dr. Philip Thorpe, professor of pharmacology at UT Southwestern Medical Center and a scientific advisor to Peregrine. "Last year we published data from preclinical imaging studies confirming bavituximab's high specificity for targeting tumor blood vessels with little or no localization to normal tissue.(1) Bavituximab's ability to achieve unusually clear images of tumors in living animals in these studies supports the concept that PS-targeting antibodies may be useful for the non-invasive detection of tumors and their metastases in cancer patients."

The new patent claims methods for imaging solid tumors using PS-targeting antibodies coupled to a variety of imaging agents.

"Issuance of this broad vascular imaging patent ex
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SOURCE Peregrine Pharmaceuticals, Inc.
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