Navigation Links
Perampanel for epilepsy: No proof of added benefit
Date:1/30/2013

iramate was "not productive". But IQWiG does not accept this explanation from the manufacturer.

Comparisons with lamotrigine not adequate

In order to demonstrate the added benefit over lamotrigine, the manufacturer provided data on a direct and an indirect comparison. However, ultimately the former comparison was with a dummy drug (a placebo). Although in this case a placebo comparison can prove a benefit, it cannot prove an added benefit.

For various reasons, the indirect comparison is also inadequate. Amongst other things, perampanel was not tested here against lamotrigine (in each case as add-on therapy), but instead a combination of perampanel and lamotrigine against lamotrigine, in each case in addition to basic treatment, was tested.

Since neither the indirect nor the direct comparisons are suitable for answering the research question, no relevant study results are available for the benefit assessment. Hence there is also no proof of an added benefit.

G-BA decides on the extent of added benefit

The dossier assessment is part of the overall procedure for early benefit assessments supervised by the G-BA. After publication of the manufacturer's dossier and IQWiG's assessment, the G-BA conducts a commenting procedure, which may provide further information and result in a change to the benefit assessment. The G-BA then decides on the extent of the added benefit, thus completing the early benefit assessment.


'/>"/>

Contact: Anna-Sabine Ernst
presse@iqwig.de
49-221-356-85153
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2

Related medicine news :

1. No Proof That Gum Disease Causes Heart Disease, Experts Say
2. More Proof That Healthy Habits Fight Disease
3. More Proof Cranberry Juice Thwarts Infection
4. No proof that patients lose weight after joint replacement surgery
5. Vandetanib in thyroid cancer: No proof of added benefit
6. No Proof That Doping With EPO Gives Athletes an Edge: Review
7. Corporate Whistle Blower Center Now Urges Physicians, Medical Device or Drug Insiders With Proof A Company Knowingly Sold A Bad Product to Become a Whistleblower
8. Corporate Whistle Blower Center Now Urges Physicians to Become a Whistleblower if They Have Proof a Medical Device or a Drug Product was Defective-and it was Sold Anyway
9. Pesticides and Parkinsons: UCLA researchers uncover further proof of a link
10. Corporate Whistle Blower Center Now Urges Physicians Medical Device and Drug Industry Insiders To Step Up-If They Have Proof Of Serious Wrongdoing or Overbilling
11. No Proof Drugs Ease Kids Migraines: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... with friends is a big part of being young, and ... look graceful without spending a large sum of money. Recently, ... prom dresses. Apart from this, it has launched a big ... all the global consumers can enjoy a discount, up to ... , The company’s chief executive officer says, “We are proud ...
(Date:9/18/2014)... Petersburg, FL (PRWEB) September 19, 2014 ... with patented ingredients made just for these issues in ... includes Matrixyl, Haloxyl and Eyeliss," says Kathy Heshelow, founder ... inflammation, improving circulation and boosting collagen, to improve the ... special eye serum for wrinkles, dark circles and ...
(Date:9/18/2014)... September 18, 2014 Active Aging Week ... older as fully participating members of society and promotes ... celebrate, The Stafford – a boutique retirement community located ... will host two screenings of Cyber-Seniors - a humorous ... our residents to watch this great film,” says Thomas ...
(Date:9/18/2014)... Dr. David A. F. Ellis is a ... of Facial Plastic and Reconstructive Surgery and a Professor ... Facial Plastic Surgery. He is recognized around the ... , Dr. Ellis will be presenting on numerous injectable ... injection techniques and various treatments for complications associated with ...
(Date:9/18/2014)... 2014 A jacket is a hip- ... typically has sleeves, and fastens in the front or ... tighter-fitting, and less insulating than a coat, which is ... protective clothing. Today, Fecbek, a well-known clothing manufacturer and ... men’s jackets; all these items are offered at extremely ...
Breaking Medicine News(10 mins):Health News:With New Semester Under Way, LunaDress Unveils The Most Fashionable Prom Dresses 2Health News:The Secret to Improving Under-Eye Skin: 30% Off Sale and Report on Ingredients Ends Tonight on the Face Whisperer® Advanced Eye Gel 2Health News:In Support of Active Aging Week, a Lake Oswego Retirement Community Will Get a Sneak Peek at an Inter-Generational Documentary – Cyber-Seniors 2Health News:Dr. David A. F. Ellis Has Been Invited to Speak at a Conference of the American Academy of Facial Plastic and Reconstructive Surgery in Orlando, Florida 2Health News:Cool Jackets Are For Sale At Fecbek.com 2
... MONDAY, May 4 (HealthDay News) -- Women may be ... according to a new study. , In an examination ... had been referred to a lung cancer center between ... tended to be younger when they developed the disease, ...
... Data Sharing Capabilities of PrimeSuite Enables Physicians to Make ... EssenceCARROLLTON, Ga., May 4 Greenway Medical Technologies continues ... point-of-care solutions that equip physicians with the tools necessary ... time is of the essence. Greenway,s recent participation in ...
... directly from worldwide headlines, Spike TV has begun production ... "Surviving Disaster" focused on how to survive a swine ... be shot in Los Angeles and no airdate has ... )In "Surviving Disaster," Spike TV presents a series ...
... and brand reflects regional vision for healthcare service ... and LANGHORNE, Pa., May 4 Frankford Hospital ... to Aria (pronounced ARE-EE-UH) Health. The decision ... at its existing hospital and outpatient locations comes ...
... The Monell Center announced today that it has received ... & Melinda Gates Foundation. The grant will support ... A. S. Breslin, PhD, titled "Taste-Guided Behavior on Mosquitoes ... of 81 grants announced by the Gates Foundation in ...
... is known to have a positive effect on maintaining a ... the Journal of Thoracic Oncology has shown that ... secondary prevention of cancer. The Journal of Thoracic Oncology ... the Study of Lung Cancer. Dr. Jennifer Temel at Massachusetts ...
Cached Medicine News:Health News:Smoking Packs a Tougher Wallop for Women 2Health News:Greenway Medical Technologies' PrimeSuite Solution Provides OB/GYN Physicians With Instant Access to Labor and Delivery Information at Point-of-Care 2Health News:Greenway Medical Technologies' PrimeSuite Solution Provides OB/GYN Physicians With Instant Access to Labor and Delivery Information at Point-of-Care 3Health News:Greenway Medical Technologies' PrimeSuite Solution Provides OB/GYN Physicians With Instant Access to Labor and Delivery Information at Point-of-Care 4Health News:Spike TV Goes Into Production of Special Episode of Original Series 'Surviving Disaster' Focused on the Swine Flu and Other Pandemics 2Health News:Frankford Hospital Changes Its Name to Aria Health 2Health News:Monell Center receives $100,000 Grand Challenges Explorations grant 2
(Date:9/18/2014)... , Sept. 18, 2014  Neurotrope, Inc. (OTCQB: NTRP) ... , M.D., Ph.D. to the Company,s Board of Directors, ... fills a vacancy on the Board of seven members. ... and Corporate Governance Committee and a member of the ... a member of Neurotrope,s Scientific Advisory Board, a position ...
(Date:9/18/2014)... , September 18, 2014 After ... chain community, we,re finally here - the new programme for ... January 2015, part of our global Cool Chain series, has ... here ! As the lines between supply ... put together a programme that is broad and yet specific, ...
(Date:9/18/2014)... Relmada Therapeutics, Inc., (OTCQB: RLMD), a clinical-stage ... pain, announced today that it has appointed Mr. ... Director of Clinical Development. During his extensive ... led successful global clinical operations teams, in the US ... clinical development of numerous therapeutics and diagnostics across a ...
Breaking Medicine Technology:Larry D. Altstiel, M.D., Ph.D. Joins Neurotrope Board of Directors 2Larry D. Altstiel, M.D., Ph.D. Joins Neurotrope Board of Directors 3Larry D. Altstiel, M.D., Ph.D. Joins Neurotrope Board of Directors 4Europe's Biggest and Longest-Running Gathering of Life Sciences Logistics, Supply Chain & QA Professionals 2Relmada Therapeutics, Inc. Appoints Christopher W. James As Senior Director of Clinical Development 2
... 2011 Nationally-acclaimed researcher and award-winning author Dr. Cynthia ... National Conference on Cancer Nursing Research that silver treated ... were supposed to prevent. After testing ... with silver coated or silver impregnated fluid pathway components, ...
... Pharmaceuticals, Inc. (Nasdaq: OPTR ) today announced the ... shares of its common stock, offered at a price to ... Optimer from this offering are expected to be $67.5 million, ... offering expenses payable by Optimer.  The offering is expected to ...
Cached Medicine Technology:Instead of Preventing Infections, Silver Coated Needleless IV Connectors May Actually Cause Them, a Nationally-Recognized Expert Tells National Conference on Cancer Nursing Research 2Optimer Pharmaceuticals, Inc. Prices Public Offering of Common Stock 2Optimer Pharmaceuticals, Inc. Prices Public Offering of Common Stock 3
... Pens-Using a proprietary and patented technology, ADI ... called Antigen-Antibody pens-TM, that will allow researchers ... in any form or shape or size. ... to see antigen being written on the ...
... Antigen-Antibody Pens-Using a proprietary and patented technology, ... pens, called Antigen-Antibody pens-TM, that will allow ... membranes in any form or shape or ... helps to see antigen being written on ...
... Pens-Using a proprietary and patented technology, ADI ... called Antigen-Antibody pens-TM, that will allow researchers ... in any form or shape or size. ... to see antigen being written on the ...
... 350 Liters of pure water, Complete, Compact ... Purified Water,Millipores compact S.D.S. Storage and Distribution ... 350 liters of purified water produced by ... consistent purity of stored water, provide effective ...
Medicine Products: