Navigation Links
'Pep talk' can revive immune cells exhausted by chronic viral infection
Date:12/13/2011

Chronic infections by viruses such as HIV or hepatitis C eventually take hold because they wear the immune system out, a phenomenon immunologists describe as exhaustion.

Yet exhausted immune cells can be revived after the introduction of fresh cells that act like coaches giving a pep talk, researchers at Emory Vaccine Center have found. Their findings provide support for an emerging strategy for treating chronic infections: infusing immune cells back into patients after a period of conditioning.

The results are published this week in Proceedings of the National Academy of Sciences Early Edition.

The first author of the paper is Rachael Aubert, a student in Emory's Immunology and Molecular Pathogenesis program who completed her doctorate in 2009. Senior author Rafi Ahmed, PhD, is director of the Emory Vaccine Center and a Georgia Research Alliance Eminent Scholar.

Ahmed's laboratory has extensive experience studying mice infected with lymphocytic choriomeningitis virus (LCMV). Immune responses against LCMV are driven by CD8 or "killer" T cells, which destroy virus-infected cells in the body. But a few weeks after exposure to LCMV, the mice develop a chronic infection that their immune systems cannot shake off, similar to when humans are infected by viruses like HIV and hepatitis C.

Aubert and her co-workers examined what happened to mice chronically infected with LCMV when they infused CD4 or "helper" T cells from uninfected mice. After the infusion, the CD8 cells in the infected mice revived and the levels of virus in their bodies decreased by a factor of four after a month. Like coaches encouraging a tired athlete, the helper cells drove the killer cells that were already in the infected mice to emerge from exhaustion and re-engage.

The cell-based treatment was especially effective when combined with an antibody that blocks the molecule PD-1, which appears on exhausted T cells and inhibits their functioning
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dr. Luther T. Clark to present Merck Academy Talk at SUNY Downstate
2. Talking About Size, Shape May Aid Math Skills
3. Law barring doctors talking to patients about gun ownership undermines public health issue
4. With Rude Workers, Customers Walk but Dont Talk
5. Talking -- or Not Talking -- Can Give Cancer Patients a Sense of Control
6. Rules Help When Talking About Infertility
7. High-risk stroke patients more likely to get follow-up care after motivational talk
8. Spiritual Talks May Boost Patients View of Hospital Care
9. Special Talk Therapy Seems to Help Dying Patients
10. Talking to Teens May Help Them Cut Back on Pot Smoking
11. Tots Who Are Late Talkers Typically Turn Out Fine: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... Metamora, Michigan (PRWEB) May 24, 2015 ... allow them to take pressure measurements in patients’ bladder ... The doctor usually orders it if they have reported ... (OAB). , Women’s Excellence in Bladder Control ... with unwanted urinary leakage or problems with overall control ...
(Date:5/24/2015)... ProPin is a set of self-animating 3D pin markers ... to pin point locations on a map, to indicate prices or ... users to choose from 30 simplistic presets with geometric design elements ... editors can easily manipulate ProPin presets as a whole. Pixel ... , Using ProPin is easy, simply drag a preset into the ...
(Date:5/24/2015)... CA (PRWEB) May 24, 2015 ... clear indicator that the single best option for avoiding ... reveals that fitness level was the single most powerful ... for variables such as diabetes and family history of ... of maintaining lifelong heart and lung fitness. , The ...
(Date:5/23/2015)... Diego, CA (PRWEB) May 23, 2015 ... especially small businesses, are finding it increasingly difficult to ... businesses which fail to provide adequate insurance for employees ... for businesses been such an integral part of a ... more affordable healthcare for businesses, Online USA Doctors has ...
(Date:5/23/2015)... 23, 2015 A live auction will be ... hospitals, surgery centers and other medical facilities around the United ... endoscopy, lab, radiology, surgery, anesthesia, exam and much more. ... and Thursday, May 28 starting at 9:00am CDT each day. ... N. 25th Avenue, Melrose Park, IL 60160. Anyone can ...
Breaking Medicine News(10 mins):Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 3Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 3Health News:Over 5,200 Lots of Medical Equipment Will Be Sold by Live Auction 2
... of millions of dollars annually in medical care, suggesting ... improve outcomes but also save substantial amounts of money, ... nearly 150,000 people in six states. , "Substance abuse ... think," said Robin E. Clark, PhD, associate professor of ...
... to malignancy, study suggests , , MONDAY, Jan. 5 (HealthDay ... hormone replacement therapy may face an increased risk of ... suggests. , Interestingly, obese women who have used hormone ... face increased risk for this type of malignancy. , ...
... National Hot Tea Month, the Height of the Cold and Flu ... and is also the height of the dreaded "cold and flu ... Americans affected by the cold and flu this year, which leads ... one do to avoid the cold and flu?The CDC strongly recommends ...
... During the Same Study Period, According To New ... Arlington Medical Resources (AMR), a provider of ... imaging industries, finds that the number of micro-bubble ... increased by more than 50 percent, to nearly ...
... Jan. 5 Vocollect Healthcare Systems, Inc.,announces ... Louisiana, is,deploying AccuNurse(R) voice-assisted care in four ... part of its implementation, Central Control will,begin ... in the next two,largest facilities -- Camelot ...
... of a Survey Kiosk buyer,s guide. The guide explains how ... their customers by capturing real-time in-store customer feedback. , ... ... 2009 -- Opinionmeter International, developer of the award winning customer ...
Cached Medicine News:Health News:Substance abuse adds millions to Medicaid's total health care costs 2Health News:Substance abuse adds millions to Medicaid's total health care costs 3Health News:Obesity Linked to Ovarian Cancer 2Health News:Obesity Linked to Ovarian Cancer 3Health News:Flu Season is Tea Time 2Health News:Micro-Bubble Echo Contrast Procedures Continue to Rebound in October 2008 2Health News:Micro-Bubble Echo Contrast Procedures Continue to Rebound in October 2008 3Health News:Central Control is First Louisiana-Based Organization to Deploy Voice-Assisted Care 2Health News:Central Control is First Louisiana-Based Organization to Deploy Voice-Assisted Care 3Health News:Guide for Using Survey Kiosks for Instant Customer Feedback Sponsored by Opinionmeter 2Health News:Guide for Using Survey Kiosks for Instant Customer Feedback Sponsored by Opinionmeter 3
(Date:5/22/2015)... NEW YORK , May 22, 2015 /PRNewswire/ ... segment of the $13 billion global cardiac rhythm ... Kalorama Information.  Kalorama found that Medtronic, St. Jude ... Medical) command 80% of this market segment. The ... Management Device Markets , uses 2015 as a ...
(Date:5/22/2015)... , May 22, 2015  RegeneRx Biopharmaceuticals, ... announced a peer-reviewed publication of the results of ... RGN-259 (RegeneRx,s preservative-free eye drops) for the treatment ... adverse environment (CAE ® ) model.  The exploratory ... results, which were previously disseminated by the Company ...
(Date:5/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/3rthk2/latest ... "Latest Regulations on Pharmaceutical International Multi-Center Clinical Trials ... This is first time in history, Chinese ... multi-center clinical trials of drugs in ... implemented on March 1, 2015. The guidance provides ...
Breaking Medicine Technology:Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 42015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
... Recovery Systems announced today that it has been awarded ... the group purchasing unit of the Premier healthcare alliance, ... its more than 75,000 healthcare member facilities. After hearing ... LRS Director of Marketing commented, " We are very ...
... "Simple Inspirations," a new contest, sponsored by Bayer ... diagnosed patients by sharing their most inspirational thoughts about ... is to enrich the lives of everyone who has ... -- and to demonstrate that people with diabetes can ...
Cached Medicine Technology:Life Recovery Systems Awarded Contract With Premier for Patient Temperature Management 2Life Recovery Systems Awarded Contract With Premier for Patient Temperature Management 3Nick Jonas and Bayer HealthCare Announce "Simple Inspirations" Contest to Motivate and Support Those Newly Diagnosed with Diabetes 2Nick Jonas and Bayer HealthCare Announce "Simple Inspirations" Contest to Motivate and Support Those Newly Diagnosed with Diabetes 3
... a leading provider of immunofluorescence assays, with ... that includes kits for autoimmune diseases, infectious ... conjugates and components. Our Impact IFA Test ... substrates and kit sizes to choose from. ...
... Inverness Medical Professional Diagnostics is a leading ... IFA and DFA test menu that includes ... STDs as well as miscellaneous conjugates and ... you a wide assortment of substrates and ...
... is a leading provider of immunofluorescence assays, ... menu that includes kits for autoimmune diseases, ... miscellaneous conjugates and components. Our Impact IFA ... of substrates and kit sizes to choose ...
... is a leading provider of immunofluorescence assays, ... menu that includes kits for autoimmune diseases, ... miscellaneous conjugates and components. Our Impact IFA ... of substrates and kit sizes to choose ...
Medicine Products: