Navigation Links
Penn vet team uncovers a pathway that stimulates bone growth
Date:2/13/2013

has become clear that BMPs have some issues with safety and efficacy," Hankenson said. "In the field we're always searching for new ways for progenitor cells to become osteoblasts so we became interested in the Notch signaling pathway."

This molecular signaling pathway is found in most animal species and is known to play a role in stem cell differentiation. The researchers chose to investigate one of the proteins that acts in this pathway by binding to the Notch receptor, Jagged-1. The Penn Vet team has previously shown that Jagged-1 is highly expressed in bone-forming cells during fracture healing and that introducing Jagged-1 to mouse stem cells blocked the progression of stem cells to osteoblasts.

"That had been our operating dogma for a year or two," Hankenson said.

Next the researchers decided to see what happened when Jagged-1 was introduced to human stem cells. There they came upon a very different result.

"It was remarkable to find that just putting the cells onto the Jagged-1 ligand seemed sufficient for driving the formation of bone-producing cells," he said.

This finding aligns with other evidence linking Jagged-1 to bone formation. Patients with a rare disease known as Alagille syndrome frequently have mutations in the gene that codes for Jagged-1. Individuals with this condition have problems with their metabolism that severely affect their livers but also tend to have challenges with their skeletal system and break bones easily.

Furthermore, genome-wide association studies, which search large populations for mutations that may be linked with particular characteristics, have found a connection between mutations near the Jagged-1 gene and low bone mass.

Hankenson has multiple collaborations with other researchers at Penn to further investigate how manipulating the Jagged-1 protein may one day help patients. He is working with Kathleen Loomes of Penn's Perelman School of Medicine and the Ch
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cervalis Uncovers Big Issues for Data Center Executives in 2013
2. Gene Study Uncovers More Autism Clues
3. Bigger human genome pool uncovers rarer variants
4. Study uncovers simple way of predicting severe pain following breast cancer surgery
5. National survey of economists uncovers vast gender gap in policy views
6. New research uncovers diverse metabolic roles for PML tumor suppressor gene
7. UCLA/Technion study uncovers brains code for pronouncing vowels
8. Tips for Making the Holidays Safer and Calmer for Dementia Patients from Pathways Home Health & Hospice
9. Mayo Clinic-led study unravels biological pathway that controls the leakiness of blood vessels
10. Pathways Home Health & Hospice Receives 2012 HomeCare Elite Top Honor for Quality Care
11. Study identifies potential new pathway for drug development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... 27, 2015 Healthpointe is proud to ... M.D., is now treating knee and hip joint disorders ... , Long Beach, and La Mirada. Dr. Stanley Katz ... and hip joint disorders as well as chronic conditions ... in returning his patients back to their normal lives. ...
(Date:3/27/2015)... While deep learning was the topic of ... (GTC) , the CEO of one start-up spoke passionately about ... lifespan well beyond the generally-agreed ceiling of 120 years. , ... one of 12 companies recognized as the hottest GPU-powered startups ... GTC Emerging Companies Summit have business models focused ...
(Date:3/27/2015)... On March 19, 2015, at ... Lions wide receiver Herman Moore, hosted “Fighting Addiction ... substance abuse, treatment options and the recent changes ... pastors, ministers and bishops from local churches as ... , “Our ‘Fighting Addiction Together’ luncheon was informative ...
(Date:3/27/2015)... UK (PRWEB) March 27, 2015 GenSight, ... it has appointed Sean Fitzgerald, a former technology and ... Operating Officer and Interim Chief Financial Officer. , Mr ... education technology innovator, EverFi, backed by Amazon founder and ... founder Evan Williams. Prior to EverFi, he was a ...
(Date:3/27/2015)... When struck with the aftermath of a trucking ... begin. The latest eBook released by Dax Jones ... victims a clear and concise process for obtaining the ... injury claim is seen through to successful completion. , ... should be taken immediately following the trucking incident. From ...
Breaking Medicine News(10 mins):Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 2Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 3Health News:InSilico Medicine, Inc. Stands Out from High Tech Startups at 2015 GPU Conference 2Health News:InSilico Medicine, Inc. Stands Out from High Tech Startups at 2015 GPU Conference 3Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2Health News:GenSight Appoints Former Technology Executive as Chief Operating Officer 2Health News:Dax Jones Updated eBook on Trucking Accidents Offers Helpful Information to Crash Victims 2
... , MURRIETA, Calif., Sept. 16 Forterus ... drug and alcohol rehabilitation and a variety of other behavioral healthcare ... has updated its web sites at www.forterushealthcare.com ... , , "It is very important that visitors ...
... ... of scientifically targeted nutritional stacks developed by Max Muscle Sport Nutrition available online at ... Anaheim, CA ... of all time, Max Muscle Sports Nutrition athlete and UFC 106 heavyweight title contender Shane ...
... ... summarized within Smart But Feeling Dumb, Dr. Levinson,s groundbreaking research effort has demonstrated ... ADD, Dyspraxia, Anxiety, Phobias, Panic, etc.) all result from a signal scrambling dysfunction ... - 85% of treated patients respond favorably to inner-ear-enhancing medications and nutrients. ...
... Sept. 15 The following was released today by True Torah Jews: ... are concerned about the ongoing accusations of an Israeli hospital, Hadassah, against ... at 50 W. 58th St. this Wednesday, September 16 at 3:30 PM. ... half years of age, was hospitalized at Hadassah on and off for ...
... ... stockholders, agree on ten crucial issues at the center of the health care debate, according ... ... Two groups that drive the American economy, small business owners and stockholders, agree on ten ...
... NEW YORK, Sept. 15 The phrase "High Five" has a ... also about the importance of losing weight. , , ... http://inr.mediaseed.tv/oneClip_C/?feed=aHmxldfx7n1A1TL9XeQmBSEb7YP2NUTr , , Registered journalists can ... use at http://www.mediaseed.tv . , , ...
Cached Medicine News:Health News:Forterus Inc. Launches Updated, Improved Web Site 2Health News:UFC Title Fight Has Stacked Advantage 2Health News:UFC Title Fight Has Stacked Advantage 3Health News:UFC Title Fight Has Stacked Advantage 4Health News:Back to School - Dramatic Medical Help and Hope for the Learning Disabled 2Health News:Back to School - Dramatic Medical Help and Hope for the Learning Disabled 3Health News:American Jews to Protest Against Hadassah Hospital 2Health News:Small Business Owners and Stockholders Agree on Ten Crucial Health Care Reform Issues, According to New Zogby/O'Leary Poll 2Health News:Small Business Owners and Stockholders Agree on Ten Crucial Health Care Reform Issues, According to New Zogby/O'Leary Poll 3Health News:Small Business Owners and Stockholders Agree on Ten Crucial Health Care Reform Issues, According to New Zogby/O'Leary Poll 4
(Date:3/27/2015)... , March 27, 2015 /CNW/ - Covalon Technologies ... medical technologies company, today announced the issuance of an ... of the Company and an aggregate of 120,500 stock ... stock options will vest over three years and will ... an exercise price of $1.40 per stock option. ...
(Date:3/27/2015)... 2015 /PRNewswire/ - Medicure Inc. (the "Company") (TSXV:MPH, OTCQB:MCUJF) ... the grant of an aggregate of 236,070 options to ... of the Company pursuant to the Company,s Stock Option ... on the tenth anniversary of the date of grant, ... of the date of grant and 50,000 are set ...
(Date:3/27/2015)... Ga. , March 27, 2015  Holographic Optical ... in the field of holographic medical imaging, is entering ... its Kickstarter campaign. Launching on April 20 th , ... and Voxbox Pro. The 8-inch and 22-inch displays will ... home for the first time. In addition to the ...
Breaking Medicine Technology:Covalon Announces Issuance of Stock Options 2Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 2Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 3
... the progression of heart failure in asymptomatic and mildly ... Boston Scientific Corporation (NYSE: BSX ) ... today announced that the landmark MADIT-CRT trial has met ... cardiac resynchronization therapy defibrillators (CRT-Ds) to be associated with ...
... Secrets of a Childhood Cancer-- , , PHILADELPHIA, June ... Philadelphia advance the search for genetic events that result in ... , Originating in the peripheral nervous system, neuroblastoma is the ... percent of all childhood cancer deaths. , , "Only ...
Cached Medicine Technology:MADIT-CRT Trial Meets Primary Endpoint 2MADIT-CRT Trial Meets Primary Endpoint 3MADIT-CRT Trial Meets Primary Endpoint 4Gene Findings Unlocking Reasons for Neuroblastoma Risk 2Gene Findings Unlocking Reasons for Neuroblastoma Risk 3Gene Findings Unlocking Reasons for Neuroblastoma Risk 4
One inch disposable patch electrode uses a specially formulated adhesive solid gel. Reusable lead wire with snap connector provides economic benefits. Ideal for sleep studies where leg movement or EK...
... Made with elastic fabric, these head cap ... need to begin testing. Each Electro-Cap System ... the International 10-20 System. When you place ... are using with your head cap system ...
... When testing takes you into the OR, ER, ... protection of Cadwells new shielded electrodes. Keeping noise ... and paired disc electrode has a special shielded ... the damaging effects of 60-cycle interference. That means ...
... 3 (Binocular Indirect Ophthalmo-Microscope) incorporates the principle of ... a view of up to 130 degrees of ... the eye may be rotated freely so that ... Even surgery through small pupils is possible. ...
Medicine Products: