Navigation Links
Penn team links schizophrenia genetics to disruption in how brain processes sound
Date:10/13/2011

PHILADELPHIA - Recent studies have identified many genes that may put people with schizophrenia at risk for the disease. But, what links genetic differences to changes in altered brain activity in schizophrenia is not clear. Now, three labs at the Perelman School of Medicine at the University of Pennsylvania have come together using electrophysiological, anatomical, and immunohistochemical approaches - along with a unique high-speed imaging technique - to understand how schizophrenia works at the cellular level, especially in identifying how changes in the interaction between different types of nerve cells leads to symptoms of the disease. The findings are reported this week in the Proceedings of the National Academy of Sciences.

"Our work provides a model linking genetic risk factors for schizophrenia to a functional disruption in how the brain responds to sound, by identifying reduced activity in special nerve cells that are designed to make other cells in the brain work together at a very fast pace" explains lead author Gregory Carlson, PhD, assistant professor of Neuroscience in Psychiatry. "We know that in schizophrenia this ability is reduced, and now, knowing more about why this happens may help explain how loss of a protein called dysbindin leads to some symptoms of schizophrenia."

Previous genetic studies had found that some forms of the gene for dysbindin were found in people with schizophrenia. Most importantly, a prior finding at Penn showed that the dysbindin protein is reduced in a majority of schizophrenia patients, suggesting it is involved in a common cause of the disease.

For the current PNAS study, Carlson, Steven J. Siegel, MD, PhD, associate professor of Psychiatry, director of the Translational Neuroscience Program; and Steven E. Arnold, MD, director of the Penn Memory Center, used a mouse with a mutated dysbindin gene to understand how reduced dysbindin protein may cause symptoms of schizophrenia.
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Neuroscientists reveal new links that regulate brain electrical activity
2. MSU researcher links potentially deadly infection, frequent cow exposure
3. BATTLE links potential biomarkers to drugs for lung cancer
4. LifeLinks Revolutionizes Video Interpreting, Shows Spanish Interpreting in Added Dimension-VIDEO!
5. Study links microRNA to shut-down of DNA-repair genes
6. Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases
7. Experts call for urgent action to tackle strong links between impotence and heart disease
8. A Protein Links Alzheimers, Down Syndrome
9. U of M study definitively links indoor tanning to melanoma
10. New research at the University of Leicester links shoplifting to your personality
11. MSU researcher identifies links between hypertension, bipolar disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn team links schizophrenia genetics to disruption in how brain processes sound
(Date:12/25/2014)... December 25, 2014 BambooFlooringChina.com sells many ... quality bamboo flooring. Today, the company announces big ... many styles and colors. , BambooFlooringChina.com is the world’s ... the promotion is valid until Jan. 20, 2015. , ... and woven with a natural thread. All the bamboo ...
(Date:12/25/2014)... -- The risk of burns from fires and cooking ... be extra cautious, an expert says. "Between Thanksgiving ... in patients coming in with burns," said Dr. Steven ... Burn Center of Stony Brook University Hospital in New ... but if not careful, could quickly turn tragic," Sandoval ...
(Date:12/25/2014)... York (PRWEB) December 25, 2014 Thousands ... to move forward in a number of multidistrict litigations ... West Virginia, Bernstein Liebhard LLP reports. According to an ... scheduled to convene a Joint Status Conference in all ... a.m. Parties have been directed to submit a proposed ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Parker & ... outstanding customer service and affordable quality regarding heating, cooling ... announces recognition in 2014 by the “Queen of Clean” ... has earned an impressive reputation over the years for ... a wide range of contractor services for both homeowners ...
(Date:12/24/2014)... Recently, iFitDress.com, a famous dress manufacturer and retailer, has ... All these items are brand new; they are made by ... with the new range of high quality prom gowns. A ... designs are made according to the latest trends. For years, ... from the company is handpicked by skilled tailors. , In ...
Breaking Medicine News(10 mins):Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2
... and relaxation exercises can help cut the pain, experts say , ... run away from an injection, so it,s no surprise that children ... it,s time for flu shots this year. , "The good ... to positively impact their child,s experience when getting a needlestick -- ...
... , GAINESVILLE, Fla., Oct. 18 Previously e cigarettes ... product for themselves. However, Teresa Peach, an online sales ... wishing to purchase the product for their loved ones ... they wish to buy the electronic cigarette starter kit ...
... Epileptic seizures are the most dramatic and prominent aspect ... person abruptly stops a long-term or chronic drinking habit. ... into brain cells via voltage-gated calcium channels plays an ... because blocking this flow suppresses these seizures. But do ...
... , FRESNO, Calif., Oct. 17 Nearly 40 local organizations ... the Lowell Neighborhood Resource Center to host the Celebrate ... at Lowell Elementary School from 10:00 a.m. to 2:00 p.m. ... rise to 14.6 percent, the need for local health and ...
... Veterans with disorder more likely to die within a ... 17 (HealthDay News) -- Veterans with post-traumatic stress disorder ... if the surgery is performed years after they have ... Researchers analyzed data on 1,792 male veterans who had ...
... , NASDAQ: CRME ... (NASDAQ: CRME / TSX: COM) ("Cardiome" or the "Company") ... to purchase for cancellation up to US$27.5 million of its common ... October 13, 2009. Cardiome has accepted 6,470,588 of its common shares ...
Cached Medicine News:Health News:Online Sales of E Cigarettes Expected to Rise Over the Holidays 2Health News:Anthem Blue Cross Teams with Lowell Neighborhood Resource Center to Address Health and Wellness Needs in Fresno 2Health News:Post-Traumatic Stress May Raise Death Risks 2Health News:Cardiome Pharma Corp. Announces Final Results of Tender Offer 2Health News:Cardiome Pharma Corp. Announces Final Results of Tender Offer 3Health News:Cardiome Pharma Corp. Announces Final Results of Tender Offer 4
(Date:12/24/2014)... 24, 2014 Kinex Pharmaceuticals announced today that ... Roswell Park Cancer Institute. KX2-361 (KX02), a ... has shown potent inhibitory activity against a broad panel ... resistant to Temozolomide (T98G), the most widely used chemotherapy ... brain tumor mouse model, KX2-361 consistently clears brain tumors ...
(Date:12/24/2014)... FLINT, Mich. , Dec. 24, 2014  Diplomat ... largest independent specialty pharmacy, is proud to announce ... and quality at Diplomat, will take office as the ... 2015. The formal induction ceremony will take place Feb. ... which will be held at the Renaissance Center in ...
(Date:12/24/2014)... 23, 2014 Echo Therapeutics, Inc. (NASDAQ: ... focused on skin permeation, continuous glucose monitoring and ... Hollander has been appointed Chief Executive Officer ... than 20 years of experience in the medical ... recently served as Vice President, Business Development, Otsuka ...
Breaking Medicine Technology:Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... Kluwer Pharma Solutions, Inc., a leading provider of scientific information ... that Rep. Ben Quayle ( R-AZ, 3 ... analytics management team to discuss the company,s role in the ... company,s offices on Camelback Road in Phoenix to learn more ...
... WORTH, Texas, Aug. 24, 2011 The UNT System Board ... authorized in the 82nd Texas legislative session. As part of ... and UNT Dallas, the College of Pharmacy students will earn ... graduate portion of their classes on the UNT Health Science ...
Cached Medicine Technology:Congressman Quayle Talks With Wolters Kluwer Pharma Solutions About Importance of Health Information 2Congressman Quayle Talks With Wolters Kluwer Pharma Solutions About Importance of Health Information 3UNT Regents Approve New College of Pharmacy 2
Inquire...
... Hybridization Oven / Shaker : Temperature ... platform for the hybridization and incubation of ... be used for gel processing and staining. ... volumes to be used providing enhanced sensitivity ...
... (slot format) microfiltration units provide a reproducible ... in solution onto nitrocellulose or Zeta-Probe membrane. ... using interchangeable templates to form the 96-well ... SF apparatus. Each is available as a ...
... Small size is ideal for staining westerns ... used for multipurposes. Pour spouts in each ... or label may be used for identification. ... rockers or shakers for staining several gels ...
Medicine Products: