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Penn talks at ASCB touch on cancer, neurodegenerative diseases, and MD
Date:12/3/2007

WASHINGTON, DC Among the 72 posters, lectures, and mini-symposia given by University of Pennsylvania researchers at the ASCB annual meeting are talks that present new research findings on the molecular workings of several types of diseases.

The 47th annual meeting of the American Society of Cell Biology takes place on December 1-5, 2007 in Washington, D.C.

Some highlights are:

  • Huntington's Disease: A new role has been discovered for huntingtin (Htt), the defective protein in Huntington's Disease. Htt is crucial for the movement of packets inside cells that recycle and transport important molecules. Disruption of this movement by mutant Htt may help explain the nerve degeneration seen in Huntington's disease. These findings are presented by J. P. Caviston and E. L. F. Holzbaur of the Department of Physiology. (#2091, Poster 12/4)

  • Lou Gehrig's Disease (ALS): Nerve degeneration diseases such as ALS may be caused by disruption of molecular signaling, a normal process that involves transport of critical signal molecules from the nerve synapse into the nerve cell body. The study was conducted by E. Perlson, J. Ross, K. Wallace, R. Dixit, G. Jeong, R. Kalb, and E. L. Holzbaur of the Department of Physiology. (#1659, Poster, 12/4)

  • Muscular Dystrophies (MD): Some MDs are caused by the failure of muscle cells to adhere to a structural scaffold so that they can withstand cell-generated tension. Paxillin, a protein that is more abundant in some muscular dystrophies, may cause the dystrophic cells to be overly tense. This study was conducted by M. Tewari, S. Sen, A. Engler, M. Zad, and D. E. Discher of the School of Arts and Sciences, P. Acousta and H. L. Sweeney of the Pennsylvania Muscle Institute and Department of Physiology, and E. Barton of the Dental School. (#1389, Poster, 12/3)

  • Cancer: An enzyme required for normal growth and development, called ATE1, may be a tumor suppressor. Cells from mi
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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

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