Navigation Links
Penn study unlocks origins of blood stem cells
Date:12/9/2011

PHILADELPHIA A research team led by Nancy Speck, PhD, professor of Cell and Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania, has discovered a molecular marker for the immediate precursors of hematopoietic (blood) stem cells (HSCs) in the developing embryo, which provides much-needed insights for making these cells from engineered precursors.

Because HSCs, found in the bone marrow of adult mammals, generate all of the blood cell types of the body, unlocking the secrets of their origin may help researchers to better manipulate embryonic stem cells to generate new blood cells for therapy. Speck is also an Investigator with the Abramson Family Cancer Research Institute at Penn. The work was published this week in Cell Stem Cell.

"The ultimate goal for stem-cell therapies is to take precursor stem cells and push them down a particular lineage to replace diseased or dead cells in human adults or children," says Speck. First things first, she says: "You have to understand how this happens in the embryo."

Previous studies indicated that HSCs originated from a small population of cells lining blood vessels, called endothelial cells. But, it was unclear precisely which endothelial cells transitioned to blood stem cells during early development.

In the embryo, there are multiple waves of blood-cell development. The first wave gives the embryo a quick oxygen source and the final wave sets up the development of HSCs that ultimately reside in adult bone marrow. The first wave of progenitors can be generated in the lab from embryonic or induced pluripotent stem cells, but efforts to produce hematopoietic stem cells have failed, says Speck.

"Understanding the developmental origins of hematopoietic stem cells is important for learning how to produce them in the lab from embryonic or induced pluripotent stem cells," says Speck.

How much closer does this study take hematologists to be able to make HSCs successfully? Scientists can make blood cells from endothelial cells now and can monitor these in the embryo. But not all endothelial cells give rise to HSCs. The team used a special marker to follow the development of HSCs. Progenitor cells in the first wave of embryo blood-cell development and the HSCs of later waves of development differentiate from distinct populations of blood-producing endothelial cells. The marker, called Ly6a, is expressed in the endothelial cells that lead to HSCs, and it is not expressed in endothelial cells that make the first wave of blood cells.

Knowing more about the development of HSCs and its distinct markers will be helpful in making HSCs in the lab for stem-cell therapies so leukemia patients, for example many of whom are unable to find suitable donors could use their own cells to make HSCs and eventually blood cells depleted by blood cancers and some of its treatments.


'/>"/>
Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related medicine news :

1. Ready-to-bake cookie dough not ready-to-eat, study of E. coli outbreak finds
2. Few With Acute Kidney Injury See Specialists, Study Finds
3. Few Women Get Breast Reconstruction After Mastectomy: Study
4. Treating Prehypertension Lowers Stroke Risk: Study
5. Princeton study: Nighttime images help track disease from the sky
6. Study probes genetic link to sickle cell pain management
7. Rats Can Lend a Helping Paw to Others, Study Finds
8. Study shows species can change
9. Study sheds light on cancer burden in Australia
10. NEJM publishes study showing LigoCytes norovirus vaccine demonstrates protection against illness
11. Avastin Boosted Survival for Type of Aggressive Breast Cancer: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn study unlocks origins of blood stem cells
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania ... Sheraton Erie Bayfront and Erie Convention Center on June 8-10. The weekend ... student quiz bowl, award and scholarship presentations, and professional networking. , On ...
(Date:6/24/2017)... ... June 24, 2017 , ... Doorknobs are for convenience, deadbolts ... as getting a guard dog or having an alarm system installed. But unless there ... forced entry. Yair Frenkel, owner of TX Premier Locksmith in Killeen, TX says: “In ...
(Date:6/23/2017)... CA (PRWEB) , ... June 23, 2017 , ... By ... earned its ninth consecutive four-star rating from premier online charity evaluator, Charity Navigator, validating ... the top 1% of all charities reviewed by Charity Navigator and earns ANRF a ...
(Date:6/23/2017)... , ... June 23, 2017 , ... The Military Officers ... nominee for deputy secretary of Veterans Affairs, retired Marine Col. Thomas G. Bowman. , ... , Bowman brings an intimacy with the issues and challenges veterans face ...
(Date:6/23/2017)... ... , ... Everybody has their own personal preference when it comes to pornography. ... people don't like it at all. FindaTopDoc took a look at what makes people ... give readers a taste of their deepest, darkest fantasies and has the ability to ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... Israel , May 30, 2017 DarioHealth Corp. (NASDAQ: ... big data solutions, today announced that it will be presenting at ... at 8:00 AM PT. Erez Raphael , CEO, of DarioHealth ... The conference will be held on June 6th & 7th, 2017 ... companies in the small / micro-cap space. ...
(Date:5/29/2017)... May 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... which enables the functional selection of stem cells, today ... the first quarter ended March 31 st , 2017. ... accomplishments in the first quarter of 2017," said Dr. ... we announced the treatment of the first blood cancer ...
(Date:5/24/2017)... 2017  ivWatch LLC today announced the launch ... to enable seamless integration of ivWatch,s groundbreaking IV ... pumps and other devices. By integrating ivWatch technology ... help health care customers deliver a higher level ... IV therapy. "The ivWatch OEM Board ...
Breaking Medicine Technology: