Navigation Links
Penn study suggests another avenue for detecting Alzheimer's disease
Date:4/1/2011

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have determined that a well-known chemical process called acetylation has a previously unrecognized association with one of the biological processes associated with Alzheimer's disease and related disorders. The findings were published in the latest issue of Nature Communications.

Tau is one of the primary disease proteins associated with a suite of neurodegenerative diseases. Tau proteins are expressed primarily in the central nervous system where they help with the assembly and stability of microtubules, protein structures that are the backbone of the nerve-cell communication system.

"Acetylation was only detected in diseased brain tissue from patients with Alzheimer's disease or frontotemporal degeneration, suggesting it may have a role in tau transformation linked to disease onset and progression," says senior author Virginia M.-Y. Lee, PhD, director of Penn's Center for Neurodegenerative Disease Research. "This suggests that one type of acetylation is a potential target for drug discovery and biomarker development for Alzheimer's and related tauopathies."

The researchers demonstrated that tau acetylation led to a loss of one of its major functions - to promote microtubule assembly, in addition to gaining a toxic function, pathological tau aggregation. Mass spectrometry analysis identified specific acetylation sites in the tau protein sequence that overlapped with known microtubule binding sequences, so acetylation may also play a role in faulty binding of tau to microtubules.

How normal tau becomes disengaged from microtubules to form disease-related clumps remains unknown. This study shows that acetylation is most likely another chemical modification implicated in neurodegenerative disorders to be explored as a potential way to detect and fight brain disease.

According to Lee, the next steps to follow up on this discovery are to pursue basic research into the mechanisms underlying this pathological acetylation of tau and its role in neurodegeneration in Alzheimer's disease and related tauopathies. In addition, she noted that "Our highest priority will be to find ways to translate these findings into better diagnostics and therapeutics for patients with Alzheimer's disease or frontotemporal degeneration."


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related medicine news :

1. Many Moms Have Kids With Different Dads, U.S. Study Finds
2. Surprising finding from smoke inhalation study
3. Prostate Cancer Screening Doesnt Cut Death Rates: Study
4. New lung cancer staging system (TNM 7) better predicts local/regional recurrence, study shows
5. Soy increases radiations ability to kill lung cancer cells, study shows
6. Moms With Tough Childhoods More Likely to Have Smaller Babies: Study
7. For Young Kids With Pneumonia, Timing of Antibiotic Critical: Study
8. Pilot study examines stress, anxiety and needs of young women with a unique breast cancer
9. Case Western Reserve receives $1.6M to study tumor cells and immune cell detection
10. STUDY: 3 square meals a day paired with lean protein help people feel full during weight loss
11. Antibacterial Soap Additive Accumulates in Fish: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn study suggests another avenue for detecting Alzheimer's disease
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... develops, markets and sells medical devices and wearable sleep ... a strategic cooperation agreement with Hongyuan Supply Chain Management ... on June 20, 2016, to develop Dehaier,s new Internet ... agreement, Dehaier will leverage Hongyuan Supply Chain,s sales platform ...
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... inhaled drugs, announced today that it was added to ... its comprehensive set of U.S. and global equity ... an important milestone for Pulmatrix," said Chief Executive Officer ... of our progress in developing drugs for crucial unmet ...
Breaking Medicine Technology: