Navigation Links
Penn study suggests another avenue for detecting Alzheimer's disease
Date:4/1/2011

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have determined that a well-known chemical process called acetylation has a previously unrecognized association with one of the biological processes associated with Alzheimer's disease and related disorders. The findings were published in the latest issue of Nature Communications.

Tau is one of the primary disease proteins associated with a suite of neurodegenerative diseases. Tau proteins are expressed primarily in the central nervous system where they help with the assembly and stability of microtubules, protein structures that are the backbone of the nerve-cell communication system.

"Acetylation was only detected in diseased brain tissue from patients with Alzheimer's disease or frontotemporal degeneration, suggesting it may have a role in tau transformation linked to disease onset and progression," says senior author Virginia M.-Y. Lee, PhD, director of Penn's Center for Neurodegenerative Disease Research. "This suggests that one type of acetylation is a potential target for drug discovery and biomarker development for Alzheimer's and related tauopathies."

The researchers demonstrated that tau acetylation led to a loss of one of its major functions - to promote microtubule assembly, in addition to gaining a toxic function, pathological tau aggregation. Mass spectrometry analysis identified specific acetylation sites in the tau protein sequence that overlapped with known microtubule binding sequences, so acetylation may also play a role in faulty binding of tau to microtubules.

How normal tau becomes disengaged from microtubules to form disease-related clumps remains unknown. This study shows that acetylation is most likely another chemical modification implicated in neurodegenerative disorders to be explored as a potential way to detect and fight brain disease.

According to Lee, the next steps to follow up on this discovery are to pursue basic research into the mechanisms underlying this pathological acetylation of tau and its role in neurodegeneration in Alzheimer's disease and related tauopathies. In addition, she noted that "Our highest priority will be to find ways to translate these findings into better diagnostics and therapeutics for patients with Alzheimer's disease or frontotemporal degeneration."


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related medicine news :

1. Many Moms Have Kids With Different Dads, U.S. Study Finds
2. Surprising finding from smoke inhalation study
3. Prostate Cancer Screening Doesnt Cut Death Rates: Study
4. New lung cancer staging system (TNM 7) better predicts local/regional recurrence, study shows
5. Soy increases radiations ability to kill lung cancer cells, study shows
6. Moms With Tough Childhoods More Likely to Have Smaller Babies: Study
7. For Young Kids With Pneumonia, Timing of Antibiotic Critical: Study
8. Pilot study examines stress, anxiety and needs of young women with a unique breast cancer
9. Case Western Reserve receives $1.6M to study tumor cells and immune cell detection
10. STUDY: 3 square meals a day paired with lean protein help people feel full during weight loss
11. Antibacterial Soap Additive Accumulates in Fish: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn study suggests another avenue for detecting Alzheimer's disease
(Date:1/24/2017)... Philadelphia, PA (PRWEB) , ... January 24, 2017 , ... ... America, but the co-founder of the organization End Distracted Driving , Joel Feldman, ... Today. , Feldman's story was featured in one of the top newspapers in circulation ...
(Date:1/24/2017)... ... January 24, 2017 , ... Center for Hispanic Leadership (CHL) ... named Hector M. Chavez, Manager, Employee & Labor Relations at City of Hope ... Hispanic Leader of the Month. City of Hope is committed to stay out in ...
(Date:1/24/2017)... N.C. (PRWEB) , ... January 24, 2017 , ... ... Administration is the focus of a new report from the Frank Hawkins ... Business School. , Influential business leaders, academics and policy makers identified concrete solutions ...
(Date:1/24/2017)... , ... January 24, 2017 , ... ... Need to Thrive , Well-meaning studies such as the Fordham Institute’s High ... better serve top students, such as including gifted or high-achieving students as a ...
(Date:1/24/2017)... ... 2017 , ... The NewKILO JRP, a three-year project of the European Metrology ... Union (EU), was completed in May 2015. The future definition will require the unit ... air, which presents some challenges to establishing traceability to the mass scale. , This ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... , Jan. 24, 2017 Data4Cure, Inc. ... studies using its Biomedical Intelligence® Cloud - a semantic ... a multitude of genomic, molecular and clinical data that ... presented at a session hosted by Data4Cure at the ... View, CA. The company,s Biomedical ...
(Date:1/24/2017)... and PUNE, India , January ... published by Allied Market Research, titled, "Cold Chain Logistics ... Confectionary, Dairy & Frozen Dessert, Meat, Fish & Sea ... Analysis and Industry Forecasts, 2014-2022," projects that the global ... million by 2022, growing at a CAGR of 16% ...
(Date:1/24/2017)... 24, 2017 Trifecta Clinical , a ... appointing Rick Ward to Vice President of ... is also announcing the promotion of Ericka Atkinson ... Rick joins Trifecta from Greenphire where he ... senior business development positions within the healthcare industry throughout ...
Breaking Medicine Technology: