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Penn study finds living kidney donation does not increase risk of death or heart disease for older
Date:7/9/2014

PHILADELPHIA Previous studies linking older age with kidney and heart disease have raised concerns about the safety of living kidney donation among older adults. However, in the first study to look closely at this issue, researchers at the Perelman School of Medicine at the University of Pennsylvania report that older kidney donors (55 years and above) enjoy similar life expectancy and cardiovascular health as very healthy older people who did not donate their kidneys. In light of the ever increasing organ transplant waitlists, the authors of the study hope the results will provide reassurance and encouragement to older individuals who are considering living donation. The study is published this week as the cover article in the American Journal of Transplantation.

The new study matched 3,368 donors 55 years old or older with the same number of healthy non-donors, and followed them for a median of 7.8 years. Each donor was matched to a healthy older adult who was the same race, sex and very close in age. The donors and the matched healthy non-donors had similar life expectancy. In addition, researchers linked the records of the study population to a Medicare database. Among the group with Medicare insurance, donors and healthy non-donors had similar rates of cardiovascular disease and diabetes. The donors did see their primary care doctors more often, but the authors suggest that is likely due to post-donation follow-up care.

"As the population of patients on dialysis in the United States ages, it is becoming more common for older individuals, including people in their 60s and 70s, to consider live kidney donation," said lead author Peter Reese, MD, MSCE, assistant professor of Medicine in the Renal-Electrolyte and Hypertension Division, and director of the PROTECTS transplant analytics center at the Hospital of the University of Pennsylvania. "The trend makes sense because for patients on dialysis who are often then added to the kid
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Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine
Source:Eurekalert

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