Navigation Links
Penn study finds link between Parkinson's disease genes and manganese poisoning
Date:2/1/2009

PHILADELPHIA A connection between genetic and environmental causes of Parkinson's disease has been discovered by a research team led by Aaron D. Gitler, PhD, Assistant Professor in the Department of Cell and Developmental Biology at the University of Pennsylvania School of Medicine. Gitler and colleagues found a genetic interaction between two Parkinson's disease genes (alpha-synuclein and PARK9) and determined that the PARK9 protein can protect cells from manganese poisoning, which is an environmental risk factor for a Parkinson's disease-like syndrome. The findings appear online this week in Nature Genetics.

Manganism, or manganese poisoning, is prevalent in such occupations as mining, welding, and steel manufacturing. It is caused by exposure to excessive levels of the metal manganese, which attacks the central nervous system, producing motor and dementia symptoms that resemble Parkinson's disease.

In Parkinson's patients, the alpha-synuclein protein normally found in the brain misfolds, forming clumps. Yeast cells, the model system in which Gitler studies disease proteins, also form clumps and die when this protein is expressed at high levels. These are the same yeast cells that bakers and brewers use to make bread, beer, and wine.

As a postdoctoral fellow at the Whitehead Institute in Cambridge, Massachusetts, Gitler and colleagues started looking for genes that could prevent the cell death caused by mis-folded alpha-synuclein in yeast. Eventually they found a few genes to test in animal models and some were able to protect neurons from the toxic effects of alpha-synuclein. "One of the genes that we found was a previously uncharacterized yeast gene called YOR291W. No one knew what it did back in 2006," he recalls.

In the meantime, researchers in Europe published studies about a family that had an early-onset form of a type of Parkinson's disease caused by mutations in the PARK9 gene. "When I read about this study
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study suggests that inflammation may be the link between extreme sleep durations and poor health
2. Study finds genetic link between sleep disorders and depression in young children
3. Stanford study prevents pancreatic tumor growth in mice by inhibiting key protein
4. Study of Iraq veterans traumatic brain injuries to be conducted by UB researchers
5. Study confirms persistence of diversity problems in academic medicine
6. Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
7. Perceptions and experiences of homeless youth vary by race, UCSF study shows
8. New Study: Protein in the Morning Helps Dieters Stay on Track and Keep Weight Off
9. New study explores the relationship between preterm birth and autism spectrum disorder
10. Study finds preemies more likely to score positive
11. Weight loss reduces incontinence in obese women, UCSF study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn study finds link between Parkinson's disease genes and manganese poisoning
(Date:9/22/2014)... 22, 2014 Oregon Governor John ... as “Oregon Chiropractic Health and Wellness Month.” , ... (UWS) celebrates 110 years of leadership in educating ... was the first educational institution offering a doctor ... expanded over the past 110 years and now ...
(Date:9/22/2014)... Don Allred Insurance is pleased to announce the ... The satellite office, located in the Holly Hill Mall on ... and offer all of the same professional services as the ... spokesperson Scott Allred cites an expanding client base and the ... the major factors driving the decision to open a new ...
(Date:9/22/2014)... Austin, Texas (PRWEB) September 22, 2014 Join ... hosts the 1st Annual “Denim & Pearls Casino Night” Gala. ... Pok-E-Jo’s, door prizes, professional casino games, a raffle, and live ... The gala will feature a special buy-in for a ... , The funds from this event will be used ...
(Date:9/22/2014)... IsoComforter, Inc., one of the Nation’s premier ... of an innovative IsoTube technology and uniflow technology that ... ridges provide optimal contact and pain control. By utilizing ... fluid reservoir to a pad that is applied to ... continuous cold therapy for an extended period of time ...
(Date:9/22/2014)... California (PRWEB) September 22, 2014 ... care market occupies a significant presence in the ... most widespread healthcare problems globally. Key factors underlying ... lifestyle habits such as smoking; increasing levels of ... and expanding base of aging population vulnerable to ...
Breaking Medicine News(10 mins):Health News:Oregon Governor Proclaims October as “Chiropractic Month” – UWS Brought Chiropractic Health Care to Oregon in 1904 2Health News:Allred Insurance to Open New Burlington Branch Office 2Health News:Maverick’s Miracle Babies Foundation Presents the Denim & Pearls Casino Night September 26, 2014 2Health News:IsoComforter Cold Therapy Introduces Innovative IsoTube Technology 2Health News:Rising Incidence of Respiratory Diseases to Drive the Respiratory Care Equipment and Supplies Market, According to New Report by Global Industry Analysts, Inc. 2Health News:Rising Incidence of Respiratory Diseases to Drive the Respiratory Care Equipment and Supplies Market, According to New Report by Global Industry Analysts, Inc. 3Health News:Rising Incidence of Respiratory Diseases to Drive the Respiratory Care Equipment and Supplies Market, According to New Report by Global Industry Analysts, Inc. 4
... could lead to new treatments, researchers say , , WEDNESDAY, ... immune cells exhausted from fighting HIV infection has been ... that a molecule called Tim-3 is present at high ... combating HIV, the virus that causes AIDS. Blocking the ...
... physicians and caregivers to improve cultural sensitivity and ... these women to get mammograms that could save ... the Journal of General Internal Medicine. ... perceive they are being treated with disrespect and ...
... Latest Release Includes Enhanced Scheduling, Financial and ... Social Workers, GREAT RIVER, N.Y., Nov. ... of enterprise-wide software and services for health ... availability,release of version 7.5 of Helper, the ...
... bring enough benefit to offset expense , , WEDNESDAY, Nov. ... may not justify the marginal benefit, a new study ... (AHA) annual scientific sessions in New Orleans found that ... in some patients but "at a cost generally considered ...
... Demonstrate Best Strategic Use of Mergers ... ... http://www.thedeal.com ) magazine has named Abbott,( http://www.abbott.com )as the healthcare sector ... Abbott for the,most effective strategic use of acquisitions and divestitures., ...
... of Rutgers University is one of 10 2008 Pew ... Pew Charitable Trusts. Launched in 1991, the Pew Latin ... trained Latin American scientists who show potential for stimulating ... as well as fostering collaboration between scientists in Latin ...
Cached Medicine News:Health News:Way to Rescue Tired Immune Cells Fighting HIV Found 2Health News:Fear, misconceptions about screenings keep many African-Americans from getting mammograms 2Health News:Fear, misconceptions about screenings keep many African-Americans from getting mammograms 3Health News:Netsmart Technologies Releases Version 7.5 of Helper(TM) Practice Management Software 2Health News:Netsmart Technologies Releases Version 7.5 of Helper(TM) Practice Management Software 3Health News:Angioplasty Not Always Worth the Price 2Health News:Abbott Honored as One of The Deal's Most Admired Corporate Dealmakers 2Health News:Abbott Honored as One of The Deal's Most Admired Corporate Dealmakers 3
(Date:9/22/2014)... and SHANGHAI , Sept. 22, ... a global knowledge leader in healthcare technology, media ... support healthcare innovation in China ... health technologies. Continua and BHG announced this new ... held this week in Washington, DC ...
(Date:9/22/2014)... 2014 Persistence Market Research ( ... Study on Ophthalmic Devices: Asia ... market was valued at USD 29,171.5 million in 2014 and ... from 2014 to 2020, to reach an estimated value ... the full Global Market Study on Ophthalmic Devices:  Asia ...
(Date:9/22/2014)... 2014  Aethlon Medical, Inc. (OTCQB: AEMD), the ... infectious disease, cancer and other life-threatening conditions, disclosed ... (DARPA) has informed the Company that it plans ... four of a five-year $5.9 million contract that ... under DARPA,s Dialysis-Like Therapeutics (DLT) program. ...
Breaking Medicine Technology:Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 2Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 3Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 4Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 2Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 4Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 5Aethlon Medical Receives Notice of DARPA Contract Renewal 2Aethlon Medical Receives Notice of DARPA Contract Renewal 3Aethlon Medical Receives Notice of DARPA Contract Renewal 4
... SILVER SPRING, Md., March 25, 2011 The U.S. Food ... patients with late-stage (metastatic) melanoma, the most dangerous type ... ) Melanoma is the leading cause ... cases of melanoma were diagnosed in the United States ...
... CoreLab Partners, Inc , the global entity resulting ... is set to attend and actively participate in several ... two weeks. "The legacy of our organization ... physicians, scientists and operational personnel have provided to the ...
Cached Medicine Technology:FDA Approves New Treatment for a Type of Late-Stage Skin Cancer 2FDA Approves New Treatment for a Type of Late-Stage Skin Cancer 3CoreLab Partners Collaborates at Worldwide Industry Conferences 2
... for catheter or instrument introduction. The ... be peeled away and removed. The ... instrument to be introduced should be ... the sheath. Supplied sterile in peel-open ...
Used for antegrade placement of a safety wire guide prior to endourological procedures. Supplied sterile in peel-open packages. Intended for one-time use....
Used to establish a percutaneous tract into the renal pelvis for catheter placement or stone manipulation. Supplied sterile in peel-open packages. Intended for one-time use....
Used when establishing a percutaneous tract for nephrostomy drainage. The guide has a stiff shaft and a gradual transition to a very flexible distal tip. Supplied sterile in peel-open packages. Inten...
Medicine Products: