Navigation Links
Penn study demonstrates new way to boost immune memory
Date:6/4/2009

my of so-called effector cells that can clear infection. However, TRAF6-deficient CD8 T cells do not develop into a population of memory cells that can recall a particular infectious agent when the body encounters it a second time.

Using microarray analysis and a program that searches protein pathways, the team compared the gene expression profiles of TRAF6-deficient cells and cells with TRAF6 to see what stood out. "We discovered differences in genes that regulate fatty acid metabolism," says Pearce. Fatty acids can be broken down for energy and the microarray analyses revealed that TRAF6-deficient CD8 T cells exhibit altered expression of genes that regulate this process.

Consistent with the microarray findings, CD8 T cells lacking TRAF6 display defective fatty acid oxidation in response to growth factor withdrawal. Giving the mutant mice the metformin restored fatty acid oxidation and the generation of memory cells that lack TRAF6. Remarkably, this treatment also increased the generation of memory cells in normal mice, and consequently was able to significantly improve the efficacy of an experimental anti-cancer vaccine. A lack of fatty acid metabolism is correlated with lack of T-cell memory and through in vitro studies the team also saw that T cells burn more fatty acids when given metformin.

T cells proliferating to form an army of effector cells burn glucose for their energy. Non-proliferating T cells, such as memory cells, burn fatty acids, amino acids, and glucose interchangeably in a different metabolic pathway. From this, explains Pearce, "it is implied that there's a switch in metabolism somewhere along the way between proliferating and non-proliferating T cell populations." Perhaps at the peak of the proliferation, when energy is limiting and cells are metabolically stressed, there is a switch to another energy pathway to survive, say from glucose to fatty acids.

"Most T cell vaccines have a good initial resp
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Health Plans Prepare for Health Care Reform: Comparative Effectiveness, Consumerism Drive Future Changes, According to Deloitte Study
2. Study gives clues to how adrenal cancer forms
3. Protein may be strongest indicator of rare lung disease, study shows
4. People who wear rose-colored glasses see more, University of Toronto study shows
5. 5 Spanish centers join a study for a new leukemia and lymphoma treatment technique
6. Natura Therapeutics and USF receive NIH grant to study green tea compound for Alzheimers
7. FDA to Study Ways to Be More Open With Public
8. Study further expands understanding of leptins role in brain neurocircuitry
9. NASA Selects Four Proposals to Study Space Radiation Risks
10. Study Results Show CAQH CORE Certification Dramatically Cuts Administrative Costs, Accelerates I.T. Adoption by Providers and Health Plans
11. Study: Benefit to women not enough to sway men to get HPV vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... 2014 The Outlier Series announced the ... interview content from one of the exceptional women featured ... Women Game Changers . The title of the upcoming ... Changer Jenny McClendon . McClendon is currently a full-time ... the star of WeTV show, Raising Sextuplets. , Jenny ...
(Date:9/1/2014)... 01, 2014 Psychogenic Non-epileptic Seizures (PNES), ... psychological disorder that can have devastating effects on those ... epileptic seizures however, they are not produced by electrical ... It is estimated that the numbers of persons ... multiple sclerosis. , Dr. Lorna Myers, Director ...
(Date:8/31/2014)... The FDA has recently proposed ... adopted, the proposed changes would include more current nutrition ... on the label, and a new design. This change ... off the label. NutriGold fully supports the new changes ... choices. “After 20 years, it's time for a change,” ...
(Date:8/31/2014)... 31, 2014 Stuart Agren, M.D., founder ... sublingual immunotherapy to help his patients struggling with ... Dr. Agren said that it has helped many of ... many cases, restored peace of mind. , Nut allergies ... host of symptoms, including rashes, digestive distress, hay fever, ...
(Date:8/31/2014)... August 31, 2014 In the wake ... states have proposed legislation to require mandatory labeling of ... make informed purchasing decisions that affect their own health ... leader advocating for stringent measures to eliminate GMOs from ... “Information, Communication, Engagement” (I.C.E.) initiative with the objective of ...
Breaking Medicine News(10 mins):Health News:Upcoming Outlier Series eBook about Jenny McClendon, PA-C, Former Start of Raising Sextuplets 2Health News:Upcoming Outlier Series eBook about Jenny McClendon, PA-C, Former Start of Raising Sextuplets 3Health News:The Northeast Regional Epilepsy Group (NEREG) Offers First Conference on Psychogenic Non-epileptic Seizures (PNES) on September 20, 2014 in New Jersey 2Health News:NutriGold Supports the FDA's Call for an Updated Nutrition Facts Label 2Health News:NutriGold Supports the FDA's Call for an Updated Nutrition Facts Label 3Health News:NutriGold Supports the FDA's Call for an Updated Nutrition Facts Label 4Health News:Family Allergy Clinic Announces Q4 2014 Release of Oral Drops for Tree Nut Allergies 2Health News:Family Allergy Clinic Announces Q4 2014 Release of Oral Drops for Tree Nut Allergies 3Health News:NutriGold Announces its I.C.E. Initiative to Educate Consumers about GMOs in Dietary Supplements 2Health News:NutriGold Announces its I.C.E. Initiative to Educate Consumers about GMOs in Dietary Supplements 3
... The George Washington,University Medical Faculty Associates (MFA) ... been named an American Society for Metabolic,and Bariatric ... Center of Excellence designation recognizes surgical programs with ... surgery., According to a report released in ...
... 5 Carrington,Laboratories, Inc. (OTC Bulletin Board: CARN) ... its wholly-owned subsidiary,will be webcast live from the ... &,Renshaw 9th Annual Healthcare Conference at New York ... pm Eastern Time. The presentation will cover ...
... Nov. 5 Lincoln Financial,Advisors, part of ... announced today that it has entered into ... to provide its members access to,services provided ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050830/LFLOGO ) ...
... 5 - Players for the NFL,s,Chicago Bears will visit ... VA medical center, as part of the Disabled American,Veterans ... visit the hospital at 2:30 p.m., to honor,veterans for ... and helping brighten the day for those who have ...
... CVS/pharmacy highlights available ... resources for diabetes sufferers, WOONSOCKET, R.I., Nov. ... and an estimated 6.2 million are unaware,they have the disease, ... CVS/pharmacy will be educating and,counseling diabetes patients on topics ranging ...
... OAKLAND, Calif., Nov. 5 Michael Moore,s healthcare,"horror" film ... and,politics with its Nov. 6 DVD release, which will ... the nation, the Registered Nurse,Response Network (RNRN) reports today. ... The house parties, stretching from Alabama to Idaho, build ...
Cached Medicine News:Health News:MFA Division of Bariatric Surgery Named Center of Excellence for High-Quality Care In Bariatric Surgery 2Health News:MFA Division of Bariatric Surgery Named Center of Excellence for High-Quality Care In Bariatric Surgery 3Health News:Carrington's DelSite Presentation at Rodman & Renshaw Conference to be Webcast Live on November 7th 2Health News:Lincoln Financial Advisors to Provide Exclusive Services to American Osteopathic Association Members 2Health News:Lincoln Financial Advisors to Provide Exclusive Services to American Osteopathic Association Members 3Health News:CVS Pharmacists Serve a Vital Role in Helping Patients Manage Diabetes 2Health News:Nurses Across Nation Host SiCKO House Parties to Urge Guaranteed Healthcare as DVD Released 2
(Date:8/30/2014)... 30, 2014   Royal Philips  (NYSE: PHG, AEX: ... a new ultrasound system designed to enable global hospitals ... patient volumes and cost pressures. Making its debut at ... Barcelona this week, Affiniti provides ... with fewer resources deliver high quality patient care. ...
(Date:8/29/2014)... 29, 2014  Chuma Holdings, Inc. (OTCBB:CHUM) (the ... turnkey support services for the lawfully organized cannabis ... and approved the Company,s name and symbol change ... will be known as Chuma Holdings, Inc. ... a merger with the Company,s wholly-owned subsidiary, Chuma ...
(Date:8/29/2014)... HILL, N.C. , Aug. 29, 2014 ... face of regulatory and marketplace changes. CI leaders who ... In a new Best Practices, LLC ... host of actionable insights, including: - Use ... cheaper than primary research - Internal staff ...
Breaking Medicine Technology:Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 2Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 3Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 4CannaMed Announces Name Change and Trading Symbol Change 2CannaMed Announces Name Change and Trading Symbol Change 3Using the Competitive Intelligence Function to Drive Better Business Decisions in the Pharmaceutical Sector 2
... Oncology, Inc. formerly Champions Biotechnology, Inc. (OTC: CSBR) reported ... First Quarter Financial Results:Total operating revenues for the first ... $1.60 million in the first quarter of fiscal 2011. ... 2012 were $3.85 million compared to $2.20 million in ...
... SAN DIEGO, Sept. 13, 2011 Neurocrine Biosciences, Inc. (Nasdaq: ... and Chief Executive Officer of Neurocrine Biosciences, will be presenting ...   The live presentation takes place on ... 6:00 a.m. Pacific Time.  The presentation will be webcast and ...
Cached Medicine Technology:Champions Oncology Reports Fiscal 2012 First Quarter Financial Results 2Champions Oncology Reports Fiscal 2012 First Quarter Financial Results 3Champions Oncology Reports Fiscal 2012 First Quarter Financial Results 4Champions Oncology Reports Fiscal 2012 First Quarter Financial Results 5
Straight shafts with rounded tips. Smooth handle with dull finish....
Double-ended. 10 mm sickle shaped blade. 27 mm blunt, curved double-edged blade....
15 mm curved blade. 8 mm straight distal tip. Serrated on top of knife. Flat handle. Designated most popular model or size....
Grooved roller, on which knife oscillates....
Medicine Products: