Navigation Links
Penn study demonstrates new way to boost immune memory
Date:6/4/2009

PHILADELPHIA - After a vaccination or an infection, the human immune system remembers to keep protecting against invaders it has already encountered, with the aid of specialized B-cells and T-cells. Immunological memory has long been the subject of intense study, but the underlying cellular mechanisms regulating the generation and persistence of long-lived memory T cells remain largely undefined. Now, University of Pennsylvania School of Medicine researchers have found that a common anti-diabetic drug might enhance the effectiveness of vaccines. The findings are described this week in an advanced online publication of Nature.

In this study, an experimental preventive vaccine was made more efficacious by boosting numbers of cancer fighting T cells with the anti-diabetic drug metformin. This resulted in a larger population of memory immune cells that were able to fight off a tumor at a later time.

"We serendipitously discovered that the metabolizing, or burning, of fatty acids by T cells following the peak of infection is critical to establishing memory in those T cells," says senior author Yongwon Choi, PhD, Professor of Pathology and Laboratory Medicine. "As a consequence, we used the widely prescribed anti-diabetic drug metformin, which is known to operate on fatty-acid metabolism, to enhance this process."

"We have shown experimentally in mice that metformin increases T-cell memory as well as the ensuing protective immunity of an experimental anti-cancer vaccine," notes postdoctoral fellow and first author Erika Pearce, PhD.

"These findings were unanticipated, but are potentially extremely important and could revolutionize current strategies for both therapeutic and prophylactic vaccines," says Choi.

The lab developed mice deficient in TRAF6, a protein important in the immune response. They found that CD8 T cells deficient in TRAF6 mount an initial response, meaning they are able to proliferate into an ar
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Health Plans Prepare for Health Care Reform: Comparative Effectiveness, Consumerism Drive Future Changes, According to Deloitte Study
2. Study gives clues to how adrenal cancer forms
3. Protein may be strongest indicator of rare lung disease, study shows
4. People who wear rose-colored glasses see more, University of Toronto study shows
5. 5 Spanish centers join a study for a new leukemia and lymphoma treatment technique
6. Natura Therapeutics and USF receive NIH grant to study green tea compound for Alzheimers
7. FDA to Study Ways to Be More Open With Public
8. Study further expands understanding of leptins role in brain neurocircuitry
9. NASA Selects Four Proposals to Study Space Radiation Risks
10. Study Results Show CAQH CORE Certification Dramatically Cuts Administrative Costs, Accelerates I.T. Adoption by Providers and Health Plans
11. Study: Benefit to women not enough to sway men to get HPV vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... 31, 2014 Asked to offer ... between "Bioavailability" and "absorption," Dr. Priya Khan, Director ... great interest. "Bioavailability" and "absorption" are possibly ... the supplement industry, second perhaps only to the ... and absorption, while related, are not the same. ...
(Date:8/31/2014)... Top10BestSEOHosting.com, a reliable review website, has recently ... FatCow, Arvixe and Hostgator are the best ASP.NET hosting ... hosting companies in the world, but good suppliers are ... a reliable ASP.NET server than running a Linux server, ... believe that FatCow, Arvixe and Hostgator are the most ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 Ticket Down ... Bolivia tickets at Dick’s Sporting Goods Park in suburban ... a plethora of games against other international teams on USA ... Cup, Mexico brought a new soccer coach aboard, Miguel Herrera, ... In the build-up before the World Cup in Brazil, the ...
(Date:8/31/2014)... 2014 NutriGold announces that its ... organic fruits and berries, has been approved ... tested, including purity and label claims. , ... Acid from genetically modified and chemically produced corn ... process involves the use of a genetically modified ...
(Date:8/31/2014)... 01, 2014 Market Research Report ... 2009-2019 is a professional and in-depth market survey ... The report firstly reviews the basic information of ... manufacturing technology. , The report then explores global ... listing their product specification, capacity, production value, and ...
Breaking Medicine News(10 mins):Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 2Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 3Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 4Health News:Best ASP.NET Hosting Award for August 2014 Released By Top10BestSEOHosting.com 2Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 2Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 3Health News:NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval 2Health News:NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval 3Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 2Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 3Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 4
... AVIV, Israel, Sept. 16 The Company hereby,notifies that the ... Haft Trusts Company Ltd. ("Ziv Haft") as the trustee for,the ... Series C Notes of the,Company. The appointment of Ziv Haft ... Company Ltd., is effective as of September 8,2008, ...
... Rashad Travels to P.A.D. ,Hot Spots, During P.A.D. ... -, NEW YORK, Sept. 16 According to research,conducted ... of P.A.D. "Hot Spots" as the city with the highest ... doubles the risk of,having a heart attack or stroke and ...
... 16 JumpStart Inc., the,Northeast Ohio venture development ... and ideas, today announced the close,of an equity ... a,developer of a proprietary non-invasive ocular glucose measurement ... based, in part, on,patented technology developed at the ...
... Sept. 16 Particle Sciences, Inc.,announces the issuing ... for,increasing the density of sintered metal products. The ... a way that decreases needed,injection forces, decreases lubricant ... based on a proprietary coating,applied to the powders ...
... the European GMES Programme (Global Monitoring for Environment and ... President Gnter Verheugen announced the name today at the ... at the forum as the second flagship of the ... GMES 2008 forum is organised in the framework of ...
... Awarded the Prestigious Award for Strong Market Share Growth, ... , ... Scottsdale, Ariz ... __title__ Vulnerability Management Solutions], Inc., a leading global security ...
Cached Medicine News:Health News:First-Ever National Ranking of 'Hot Spots' for Peripheral Artery Disease (P.A.D.) Identifies Cities With Higher Risk of Heart Attack and Stroke 2Health News:First-Ever National Ranking of 'Hot Spots' for Peripheral Artery Disease (P.A.D.) Identifies Cities With Higher Risk of Heart Attack and Stroke 3Health News:First-Ever National Ranking of 'Hot Spots' for Peripheral Artery Disease (P.A.D.) Identifies Cities With Higher Risk of Heart Attack and Stroke 4Health News:First-Ever National Ranking of 'Hot Spots' for Peripheral Artery Disease (P.A.D.) Identifies Cities With Higher Risk of Heart Attack and Stroke 5Health News:Freedom Meditech Receives JumpStart Investment 2Health News:Freedom Meditech Receives JumpStart Investment 3Health News:Particle Sciences Develops Methods for Increasing Quality of Sintered Metal Products and for Coating Surfaces with Metal Oxide Films 2Health News:Kopernikus, observing our planet for a safer world 2Health News:Lumension Security Receives Frost & Sullivan 2008 Global Market Penetration Leadership Award 2Health News:Lumension Security Receives Frost & Sullivan 2008 Global Market Penetration Leadership Award 3Health News:Lumension Security Receives Frost & Sullivan 2008 Global Market Penetration Leadership Award 4Health News:Lumension Security Receives Frost & Sullivan 2008 Global Market Penetration Leadership Award 5
(Date:8/29/2014)... 29, 2014 /PRNewswire-iReach/ -- Market Research Report on ... is a professional and in-depth market survey on ... . The report firstly reviews the basic information ... and manufacturing technology. The report then explores global ... listing their product specification, capacity, Production value, and ...
(Date:8/29/2014)... , Aug. 29, 2014 The Competitive ... regulatory and marketplace changes. CI leaders who adjust will ... In a new Best Practices, LLC study CI ... actionable insights, including: - Use secondary research ... primary research - Internal staff who are ...
(Date:8/29/2014)...  A Boston Scientific Corporation (NYSE: ... and preliminary long term stricture resolution of benign ... issue of the peer-reviewed journal, Gastroenterology. ... conducted in 11 countries and five continents, and ... (FCSEMS) after extended indwell (i.e., up to 12 ...
Breaking Medicine Technology:X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 2X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 3X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 5Using the Competitive Intelligence Function to Drive Better Business Decisions in the Pharmaceutical Sector 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4
... Biocept, Inc. ("Biocept"), an emerging leader in rare cell ... has issued a patent for Biocept,s cell separation technology using ... Separation and Analysis and Method of Using" protects Biocept,s microflow ... flow path where straight-line flow is interrupted by transverse posts ...
... FRANKLIN LAKES, N.J. , May 20 David B. Snow Jr. , ... to address the 2010 Citi Investment Research Global Health Care Conference in New York ... , The presentation at the ... , Medco,s chief financial officer, is also scheduled to attend. , ...
Cached Medicine Technology:Biocept, Inc. Announces Issuance of Patent for its Microfluidic Technology 2Medco to Present at the 2010 Citi Investment Research Global Health Care Conference 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: