Navigation Links
Penn study demonstrates new way to boost immune memory
Date:6/4/2009

PHILADELPHIA - After a vaccination or an infection, the human immune system remembers to keep protecting against invaders it has already encountered, with the aid of specialized B-cells and T-cells. Immunological memory has long been the subject of intense study, but the underlying cellular mechanisms regulating the generation and persistence of long-lived memory T cells remain largely undefined. Now, University of Pennsylvania School of Medicine researchers have found that a common anti-diabetic drug might enhance the effectiveness of vaccines. The findings are described this week in an advanced online publication of Nature.

In this study, an experimental preventive vaccine was made more efficacious by boosting numbers of cancer fighting T cells with the anti-diabetic drug metformin. This resulted in a larger population of memory immune cells that were able to fight off a tumor at a later time.

"We serendipitously discovered that the metabolizing, or burning, of fatty acids by T cells following the peak of infection is critical to establishing memory in those T cells," says senior author Yongwon Choi, PhD, Professor of Pathology and Laboratory Medicine. "As a consequence, we used the widely prescribed anti-diabetic drug metformin, which is known to operate on fatty-acid metabolism, to enhance this process."

"We have shown experimentally in mice that metformin increases T-cell memory as well as the ensuing protective immunity of an experimental anti-cancer vaccine," notes postdoctoral fellow and first author Erika Pearce, PhD.

"These findings were unanticipated, but are potentially extremely important and could revolutionize current strategies for both therapeutic and prophylactic vaccines," says Choi.

The lab developed mice deficient in TRAF6, a protein important in the immune response. They found that CD8 T cells deficient in TRAF6 mount an initial response, meaning they are able to proliferate into an ar
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Health Plans Prepare for Health Care Reform: Comparative Effectiveness, Consumerism Drive Future Changes, According to Deloitte Study
2. Study gives clues to how adrenal cancer forms
3. Protein may be strongest indicator of rare lung disease, study shows
4. People who wear rose-colored glasses see more, University of Toronto study shows
5. 5 Spanish centers join a study for a new leukemia and lymphoma treatment technique
6. Natura Therapeutics and USF receive NIH grant to study green tea compound for Alzheimers
7. FDA to Study Ways to Be More Open With Public
8. Study further expands understanding of leptins role in brain neurocircuitry
9. NASA Selects Four Proposals to Study Space Radiation Risks
10. Study Results Show CAQH CORE Certification Dramatically Cuts Administrative Costs, Accelerates I.T. Adoption by Providers and Health Plans
11. Study: Benefit to women not enough to sway men to get HPV vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... May 19, 2013 Actos lawsuit ... litigation now underway in U.S. District Court, Western District ... dated May 3rd, the Court has modified the litigation’s ... eight cases rather than four. The next Status Conference ... May 23rd. (In re: Actos Product Liability Litigation, MDL ...
(Date:5/19/2013)... According to a new market ... (2013 – 2018): By Applications (Healthcare (Endoscopy, Radiology, ... CMOS, Contact IS, Infrared, X-Ray) And Geography" published ... was $8.00 billion in 2012 and is expected ... estimated CAGR of 3.84% from 2013 to 2018. ...
(Date:5/19/2013)... 19, 2013 Fat Burning Furnace developed ... that provides people with fat burning diet ... this Fat Burning Furnace package, people will receive the ... can download quickly. The Fat Burning Furnace manual includes ... build lean muscle mass. In addition, this book covers ...
(Date:5/19/2013)... Dr. Keith Chertok now provides gum disease patients with a ... the chance of a healthier smile. Laser gum surgery ... only removes diseased gum tissue in patients, but it also ... dental implants. , LANAP uses a laser to successfully ... stimulate the healthy tissue as well as encourage new bone ...
(Date:5/19/2013)... Agora Health Limited developed by Rachael Linkie is a new ... increase memory power naturally and effectively. The program also ... their entire health from the inside out. It also helps ... mind. In addition, the program helps people keep their memory ... claimed that this program can help people overcome a family ...
Breaking Medicine News(10 mins):Health News:Actos Lawyers at Bernstein Liebhard LLP Note Issuance of New Case Management Order in Federal Actos Bladder Cancer Litigation 2Health News:Actos Lawyers at Bernstein Liebhard LLP Note Issuance of New Case Management Order in Federal Actos Bladder Cancer Litigation 3Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 2Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 3Health News:Fat Burning Diet | How “Fat Burning Furnace” Helps People Lose Their Weight Naturally And Fast – V-kool 2Health News:Berkeley, CA Periodontist, Dr. Keith Chertok Now Treats Gum Disease Patients With Laser Gum Surgery Prior to Placing Dental Implants 2Health News:How To Increase Memory Power | How “Agora Health Limited” Helps People Improve Their Memory Naturally And Effectively – Health Review 2
... RICHMOND, Calif., Aug. 26 Transcept Pharmaceuticals, Inc. (Nasdaq: ... conferences. , , , Rodman & ... EDT. , Baird 2009 Health Care Conference on Thursday, ... , , A live audio webcast ...
... , SAN MARINO, Calif., Aug. 26 ... drug compounds for HIV/AIDS, autoimmune diseases, and cancer, has completed its ... of approximately 36 million additional shares of common stock in exchange ... , According to Viral Genetics, CEO Haig Keledjian, "We ...
... , , WASHINGTON, Aug. 26 ... the National Association of Psychiatric Health Systems: , , ... Psychiatric Health Systems (NAPHS), I would like to express deepest sympathies to ... , Sen. Kennedy was a staunch and unwavering supporter of ...
... , WASHINGTON, Aug. 26 Loretta King, ... Division, announced today that a federal grand jury in Denver ... commerce and with violating the Freedom of Access to Clinic ... Colorado abortion clinic. The FACE Act makes it a federal ...
... , , WASHINGTON, Aug. 26 ... health community in mourning the loss of Senator Edward M. Kennedy, ... the medically underserved. His work in advancing medical innovation has left ... to invest in cures for illnesses that affect patients around the ...
... Aug. 26 (HealthDay News) -- Two new European reports should ... diagnosing possible heart attacks in emergency room patients, cardiologists say. ... of the New England Journal of Medicine , looked ... cells. Standard practice in most hospitals now calls for a ...
Cached Medicine News:Health News:Transcept Pharmaceuticals to Present at Rodman & Renshaw and Baird Healthcare Investor Conferences on September 9 and September 10, 2009 2Health News:Transcept Pharmaceuticals to Present at Rodman & Renshaw and Baird Healthcare Investor Conferences on September 9 and September 10, 2009 3Health News:Viral Genetics Completes Second Major Debt Conversion 2Health News:Viral Genetics Completes Second Major Debt Conversion 3Health News:Council for American Medical Innovation Honors Health Champion Senator Edward M. Kennedy 2Health News:Council for American Medical Innovation Honors Health Champion Senator Edward M. Kennedy 3Health News:Newer, Better Tests for Heart Attacks 2Health News:Newer, Better Tests for Heart Attacks 3
(Date:5/18/2013)... 2013 Although colonoscopy exams prevent many colon ... sensitive method for detecting colorectal cancers 2 , the ... 3 . EndoChoice ® Inc. today unveiled research ... the accuracy of this procedure and greatly reduces the ... discussing these clinical trial results and featuring the Fuse ...
(Date:5/17/2013)... , May 17, 2013 Medical devices are ... a biological product. In light of their different mechanisms, ... are much more complicated than drug trails due to ... MD safety instead of evaluating both safety and efficacy ... FDA (which is the same as the SFDA) evaluate ...
(Date:5/17/2013)... 2013  Technology advances have had a profound ... a constantly evolving communication environment, companies need to ... with internal executives. It is challenging, however, to ... and tools that are part of today,s communication ... Best Practices, LLC explores the various internal communication ...
Breaking Medicine Technology:New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 2New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 3Statistical Challenges in Medical Device Trail Evaluation 2Internal Communication Strategies and Tactics that Resonate with Key Stakeholders and Drive Organizational Effectiveness 2
... Sept. 20, 2011 Misonix, Inc. (NASDAQ: ... designs, manufactures and markets innovative therapeutic ultrasonic products ... surgery, and other surgical and medical applications, today ... and year ended June 30, 2011.  Michael A. ...
... Johnson & Johnson (NYSE: JNJ ) today announced ... comprehensive effort designed to improve the health of as many ... countries by 2015. Since its launch last ... measurable impact in several areas toward Every Woman, Every ...
Cached Medicine Technology:Misonix Reports Fourth Quarter and Year-End Fiscal 2011 Financial Results 2Misonix Reports Fourth Quarter and Year-End Fiscal 2011 Financial Results 3Misonix Reports Fourth Quarter and Year-End Fiscal 2011 Financial Results 4Misonix Reports Fourth Quarter and Year-End Fiscal 2011 Financial Results 5Misonix Reports Fourth Quarter and Year-End Fiscal 2011 Financial Results 6Misonix Reports Fourth Quarter and Year-End Fiscal 2011 Financial Results 7Misonix Reports Fourth Quarter and Year-End Fiscal 2011 Financial Results 8Johnson & Johnson Makes Strong Progress in First Year of Initiative to Improve Health of Millions of Women and Children in the Developing World 2Johnson & Johnson Makes Strong Progress in First Year of Initiative to Improve Health of Millions of Women and Children in the Developing World 3Johnson & Johnson Makes Strong Progress in First Year of Initiative to Improve Health of Millions of Women and Children in the Developing World 4Johnson & Johnson Makes Strong Progress in First Year of Initiative to Improve Health of Millions of Women and Children in the Developing World 5Johnson & Johnson Makes Strong Progress in First Year of Initiative to Improve Health of Millions of Women and Children in the Developing World 6
... Practice management software for ... a true multi-tasking, multi-office practice ... in database technology- Winx Pro ... will assist you in effectively ...
... over 2,500 ophthalmologists nationwide, ... serve one of the ... in the country. With ... we are setting new ...
... Intuition EMR Ophthalmology is a comprehensive ... tailored for ophthalmology practices. Intuition EMR ... but provides the tools to evaluate ... you to make better decisions and ...
... the latest in advanced cartridge mixing and ... mixes and mechanically injects all types of ... ,The Revolution&trade line-up includes a large selection ... even in difficult to access areas. A ...
Medicine Products: