Navigation Links
Penn studies point to strategies for reducing painful breast cancer drug side effects
Date:9/28/2009

best to treat them."

Toxicity issues and side effects among patients taking aromatase inhibitors drugs used in post-menopausal women to prevent recurrence of breast cancer following initial treatment, by reducing the amount of estrogen the body makes lead as many as 20 percent of patients to miss prescription refills or discontinue their therapy altogether. Patients in the new study were taking aromatase inhibitors including Arimidex, Femara or Aromasin. Of the 300 patients enrolled in the study, 139 reported AI-related pain, with 75 percent of those reporting symptoms that began within the first three months of the therapy. Women most commonly had pain in their wrists, hands, and knees, though more than half said they also had pain in their backs and ankles or feet. Women who had their last menstrual period within the five years prior to beginning AIs appeared to be three times more likely to have these symptoms than women whose periods had stopped 10 or more years earlier. The authors say this finding indicates that women who entered menopause more recently may have higher levels of residual circulating estrogen in their bodies, which combined with exposure to AIs may cause a steeper, quicker drop in estrogen levels, leading to worse symptoms.

Mao and senior author Angela DeMichele, MD, MSCE, an associate professor of Medicine and Epidemiology and Biostatistics, are running a comprehensive Wellness after Breast Cancer study to examine how clinical and genetic factors relate to treatment-related symptoms such as joint pain, hot flashes, insomnia, and fatigue both during and after cancer treatment. Ultimately, they hope to identify patients at greatest risk of these symptoms and late effects of treatments, and personalize therapy in a way that will prevent the side effects of cancer therapy while maximizing the likelihood of cure.

"As modern science brings cures to many women affected by breast cancer, how to help these women to live we
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Studies Evaluate Thyroid Treatment During Pregnancy
2. Studies Find PSA Screening Unreliable
3. Fructose Boosts Blood Pressure, Studies Find
4. ACP launches ethics case studies series on MedscapeCME
5. Kayentis, the Leading Provider of the Unique "Paper-Based e-Trial" Solution, has been Retained for Six New Clinical Studies in the US Market
6. MedWaves, Inc. Sponsors Investigational Studies to Evaluate Its Patented Microwave Thermal Coagulation-Ablation System for Treatment of Tumors in Liver and Lung
7. Amgen to Present Pivotal Data From Four Phase 3 Studies at the ECCO 15 - ESMO 34 Congress
8. One Dose of Swine Flu Vaccine Offers Protection: Studies
9. NIBIB scientists increase imaging efficiency in cell structure studies
10. FDA Study Indicates Most Industry Postmarketing Studies Meet Timelines
11. Studies in animals suggest 2009 H1N1 virus may have biological advantage over seasonal influenza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... IL, April 17, 2014-- Colic affects about one in ... for numerous pediatric visits during the first several months ... colic symptoms was showing promise; however, the April 1, ... (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics and ... L reuteri for infant colic did ...
(Date:4/17/2014)... from Boston University School of Medicine (BUSM) have ... consumption in an experimental model. The findings, reported ... Alcohol Abuse , may lead to more effective ... is one of the leading causes of illness ... negative economic impact by limiting the productivity of ...
(Date:4/17/2014)... (SACRAMENTO, Calif.) An international team led by researchers ... protein complex, which plays a key role in cell ... process. This is the first time the complex has ... could make cyclin B1/Cdk1 an excellent target to control ... medicine. The research was published online today in the ...
(Date:4/17/2014)... An international research team led by Cesar A. Arias, ... Center at Houston (UTHealth) has identified a new superbug ... The report appeared in the April 17 issue of ... The new superbug is part of a class of ... or MRSA, which is a major cause of hospital ...
(Date:4/17/2014)... to find a colored ribbon representing a disease. A pink ... color ribbon does one think of with lung cancer?, Although ... suffering from the disease, black may be the only one ... lung cancer patients, primarily smokers between the ages of 51 ... stigma often felt by these patients, the emotional toll it ...
Breaking Medicine News(10 mins):Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:New MRSA superbug emerges in Brazil 2Health News:Unraveling the 'black ribbon' around lung cancer 2
... news service, along,with its production and distribution partner, NewsProNet, ... to give viewers a daily update on the,latest medical ... Each weekday starting in January 2009, HealthDay TV ... Medical Officer Dr. Cynthia,Haines, who will give insight into ...
... (ECMO) Center at University Hospitals Rainbow Babies & ... Support Award from the Extracorporeal Life Support Organization ... centers offering ECMO for support of failing organ ... award recognizes centers demonstrating an exceptional commitment to ...
... Dec. 2 New research that delivers a,wealth of ... and,manufacturing is now available in the Best Practice Database, ... Best Practices,LLC. , ... these,pharmaceutical-focused studies, go to a landing page with links ...
... Cantel Medical Corp. (NYSE: CMN ) will hold ... first quarter ended October 31, 2008 on December 5, 2008 ... be Charles M. Diker, Chairman; Andrew A. Krakauer, President; Craig ... Malkin, President of Minntech Corporation. Minntech is a Cantel subsidiary. ...
... 2 Ingenious Med (IM) welcomes new CEO, S.,Hart ... solutions, with an extensive background as a leader in ... , Founder and ... the company,s success and development in all sectors, as ...
... it in first 3 months more likely to have respiratory ... mothers take folic acid (folate) during early pregnancy may have ... study. , Folate is recommended to reduce the risk of ... acid. , The researchers examined data on more than 32,000 ...
Cached Medicine News:Health News:HealthDay TV Launches 2Health News:HealthDay TV Launches 3Health News:Best Practice Database Adds Research Highlighting Effective Tactics of Sales Force and Manufacturing Groups in the Pharmaceutical Industry 2Health News:Cantel Medical Corp. to Hold Conference Call to Discuss Results for Its First Quarter Ended October 31, 2008 2Health News:Ingenious Med Hires New CEO to Maintain and Further Expand Company Development 2Health News:Folate in Early Pregnancy May Boost Wheezing in Baby 2
(Date:1/15/2014)... , Jan. 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ... Consumables Market - Global Industry Analysis, Size, Share, Growth, ... their offering. (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ... are used on patients in order to treat dental ...
(Date:1/15/2014)... 2014 Massachusetts General Hospital (MGH), the Broad ... announced today that they have launched a strategic ... targets and develop novel therapies for inflammatory bowel ... worldwide. The MGH-Broad-Amgen collaboration brings together scientists with ...
(Date:1/15/2014)... an unprecedented effort to curb the spread of "superbugs" such as ... an advanced and portable UV germicidal lamp manufactured by MRSA-UV is ... In order to prevent EMS paramedics and transport patients ... Palm Beach Fire Rescue is the first in the ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Superbugs No Longer Ride In Rescue Vehicles 2
... Inc. (NYSE Amex: ANX ) today announced that ... at the 10th Annual BIOInvestor Forum Conference on Wednesday, October ... Cliff Salon at the Palace Hotel in San Francisco. ... and slide presentation on the ADVENTRX Pharmaceuticals web site at ...
... Innocoll, Inc. announced it has entered into a ... for CollaGUARD surgical adhesion barrier for the prevention of ... Dr. Michael Myers, President and CEO stated "This ... an increasingly important and dynamic market for medical products ...
Cached Medicine Technology:Innocoll Enters Partnership With Pioneer Pharma in China for the Distribution of CollaGUARD 2Innocoll Enters Partnership With Pioneer Pharma in China for the Distribution of CollaGUARD 3
... intra-operative MR system is ... tool for radiologists and ... of the system is ... adjunct to standard neurosurgical ...
... Adhesive (Bioglue) is a two-component surgical ... albumin (BSA) and glutaraldehyde. The BSA ... bovine spongiform encephalopathy (BSE) free countries ... inactivates viruses. The solutions are dispensed ...
Avitene Microfibrillar Collagen Hemostat (MCH) is used in surgical procedures as an adjunct to hemostasis when control of bleeding by ligature or conventional procedures is ineffective or impractical...
... Prodisc design is based upon the ... natural spinal motion segment unit. Kinematics ... integrates the biomechanical and anatomical aspects ... concept: Three implant components utilizing proven ...
Medicine Products: