Navigation Links
Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
Date:3/4/2008

PHILADELPHIA - Scientists at the University of Pennsylvania School of Veterinary Medicine have identified a protein, ISG15, that inhibits the Ebola virus from budding, the process by which viruses escape from cells and spread to infect neighboring cells. This study shows for the first time how ISG15 slows the spread of Ebola virus budding, an observation that could help explain how ISG15 successfully inhibits other viruses, including HIV-1 and herpes simplex virus type I. The findings, reported in the current issue of the Proceedings of the National Academy of Sciences, offer the promise of future treatments for Ebola outbreaks that now prove fatal for as many as 90 percent of victims.

According to the Penn Vet research team, ISG15 inhibits budding in an indirect way, by blocking the behavior of a particular host cell protein which is used by Ebola and other viruses to efficiently escape from cells. ISG15 specifically inhibits the host protein, Nedd4, used by the viral protein VP40 to escape from cells and allow for virus spread.

Inhibit the proteins used by a virus to reproduce and you are inhibiting the virus itself, Ronald Harty, lead author of the study and associate professor in the Department of Pathobiology at Penn Vet, said. Without host Nedd4, the Ebola virus still buds and attacks, but it doesnt bud as well. The long-term goal of our research is to understand the interplay between host and virus, with the hope of creating an anti-viral drug or inhibitor, much like how Tamiflu doesnt cure the flu but slows down the viral process, Harty said. The drug would be designed to dampen or slow down viral budding to allow an infected persons immune system to fight back.

The Ebola virus VP40 protein is the key player in the process of virus assembly and release from infected cells. VP40 buds from mammalian cells independent of other viral proteins, and efficient release of VP40 virus-like particles, VLPs, requires interactions with hos
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... An analysis of 32 studies compiled by ... link between lower levels of Vitamin D and a ... August 2014 issue of American Journal of Public ... Vitamin D found in blood. , Researchers found ... than 9 nanograms/milliliter (ng/mL) were twice as likely to ...
(Date:8/31/2014)... GoDaddy, IX Web Hosting and Bluehost are ... Server) hosting, which is the method of partitioning ... of which has the appearance and capabilities of ... recently compared many professional web hosting suppliers and ... VPS hosting suppliers in the global market. , ...
(Date:8/31/2014)... 01, 2014 With years of hard work, ... great secondhand construction machines. Recently, the company has updated its ... used cat 966 loaders. All these items are guaranteed to ... right now. , It is true that all items ... carefully selected by machine specialists. The firm is making full ...
(Date:8/31/2014)... Twin to twin transfusion syndrome (TTTS) ... before they were born, but an innovative fetal surgery at the ... chance at life. , Now, their parents David and Theresa Colp ... option available in St. Louis at the St. Louis Fetal Care ... Pub House (6655 Delmar Blvd, St Louis, MO 63130) on Friday, ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 NutriGold ... supplement, sourced from organic fruits and berries, has ... in all aspects tested, including purity and label ... supplements feature Ascorbic Acid from genetically modified and ... synthetic process. The process involves the use of ...
Breaking Medicine News(10 mins):Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 2Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 3Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 4Health News:GoDaddy, IX Web Hosting and Bluehost Are Awarded As Hosting Experts by Top10BestSEOHosting.com 2Health News:Delta Updates Its Wheel Loader Assortment With A Lot Of Cheap Used Cat 966 Loaders 2Health News:After a Rare Diagnosis Threatened Their Boys’ Lives, Parents Build Awareness About TTTS and Fetal Surgery Options at The SSM St. Louis Fetal Care Institute. 2Health News:After a Rare Diagnosis Threatened Their Boys’ Lives, Parents Build Awareness About TTTS and Fetal Surgery Options at The SSM St. Louis Fetal Care Institute. 3Health News:NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval 2Health News:NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval 3
... taking a traditional Indian remedy for piles known as Endopile ... test of the drug, following a complaint, had revealed harmful ... been recalled from the Singapore market. The HSA said the ... ,The complaint came from a hospital that had treated a ...
... acids is claimed to prevent more sudden deaths ... even implanted defibrillators according to US scientists.// ... compared such preventive strategies by food supplementation and ... 100,000 people that resembled the population of Olmsted ...
... in the US do not wash their hands properly.// ... had conducted the survey of 8,000 people in eight countries. ... around U.S., U.K., Italy, Germany, United Arab Emirates, India, Malaysia, ... disinfectants, mouthwash, and cleaning products. In their survey they had ...
... and made available on the World Wide Web - a ... in the body. // ,The researchers had earlier identified ... surface of cells called cilia as such a common link. ... have links associated with the tiny, hair-like cilia and implications ...
... The State University of New Jersey have modified a ... stroke patients. The game helps with hand// exercises and ... effective that similar systems, which are more expensive. The ... stroke rehabilitation. ,Virtual rehabilitation gives therapists new ...
... St. Louis and other institutions have reported that experimental ... (PXR) my help in the treatment of Niemann-Pick type ... that is often fatal within the first two decades ... model for Niemann-Pick type C (NPC) disease showed that ...
Cached Medicine News:Health News:John Hopkins Develops An Online Tool To Help In Research Of Certain Rare Diseases 2Health News:John Hopkins Develops An Online Tool To Help In Research Of Certain Rare Diseases 3Health News:Stroke Rehabilitation Through Modified Video Games 2Health News:Drugs Activating PXR May Help In Treating Niemann-Pick type C disease 2Health News:Drugs Activating PXR May Help In Treating Niemann-Pick type C disease 3
(Date:8/29/2014)... DALLAS , August 29, 2014 ... report, "Amaranth Seed Oil Market by Extraction type (SFE, ... (Cosmetic & Personal Care, Pharmaceutical, Food Supplements, Fragrance, & ... published by MarketsandMarkets, defines and segments the Amaranth ... of the market size in terms of value. ...
(Date:8/29/2014)... Aug. 29, 2014  United Therapeutics Corporation (NASDAQ: ... Court for the District of New Jersey ... company,s case against Sandoz, Inc. regarding United Therapeutics, Remodulin ... ruled that U.S. Patent No. 6,765,117 is both ... from marketing its generic product until the expiration of ...
(Date:8/29/2014)... -- Diseases largely eradicated in the United ... was declared eliminated in 2000, yet the CDC reports ... highest incidence in 20 years. In July, ... a problem of "epidemic proportions." ... these preventable diseases—in part because some parents (more than ...
Breaking Medicine Technology:Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4District Court Decision Received In Remodulin Patent Case 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3
... Device Group, the global authority on the MedTech industry, today ... is available free online to registered users. The topic of ... The Fundamentals of Level Sensing : How to Choose a ... in vitro diagnostics (IVD) professionals with information and insight into ...
... 2012 United Spinal Association,s consumer wheelchair support ... easy to read tool to guide, educate, and empower wheelchair ... wheeled mobility. (Logo: http://photos.prnewswire.com/prnh/20110413/MM82757LOGO ) ... of its kind to help navigate what is often a ...
Cached Medicine Technology:UBM Canon's Medical Device Group and Gems Sensors & Controls Announce Online Fundamentals Course for Medical Device Professionals 2United Spinal Creates UsersFirst Mobility Map: First On-line Tool for Wheelchair Consumers 2
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 9.0 mm and length 10 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 19.0 mm and length 21 mm....
... Signature is a state of the ... integrates blood, sterile body fluid and ... microbiology workstation with comprehensive capabilities. It ... and where expanded flexibility in operating ...
... The BacT/Alert 3D Select ... art, automated microbial detection system ... fluid and mycobacteria culturing. This ... data management or laboratory information ...
Medicine Products: