Navigation Links
Penn researchers show nuclear stiffness keeps stem cells and cancer cells in place
Date:2/25/2014

Adult stem cells and cancer cells have many things in common, including an ability to migrate through tiny gaps in tissue. Both types of cells also experience a trade-off when it comes to this ability; having a flexible nucleus makes migration easier but is worse at protecting the nucleus' DNA compared to a stiffer nucleus. Nuclear proteins that regulate nuclear stiffness are therefore thought to control processes as diverse as tissue repair and tumor growth.

In a study published in the Journal of Cell Biology, researchers at the University of Pennsylvania have shown that cell migration through micron-size pores is regulated by lamin-A, a nuclear protein that is very similar to the fibrous ones that make up hair.

They have also shown that a cell's ability to survive the mechanical stress of migration depends on proteins called "heat shock factors." Using an anti-cancer drug that inhibits heat shock responses, they showed that this drug's effectiveness relies on inhibiting the invasive migration of cells via the same mechanism.

Taking into account the role that lamin-A plays in increasing nuclear stiffness could help stem cell biologists and cancer clinicians interpret the diversity of nuclear shapes seen in a static sample of tissue under a microscope. Nuclei normally appear rounded but can also appear multi-lobed or greatly elongated; high lamin-A levels tend to produce the more distorted shapes after a cell squeezes its nucleus through a narrow pore.

"If we can understand more clearly the effects the lamin-A meshwork within nuclei has on the ability of cells to crawl through tiny openings," said Dennis Discher, professor in the Department of Chemical and Biomolecular Engineering in the School of Engineering and Applied Science, " then we can develop better nucleus-directed treatments for stopping the spread of cancer or for keeping stem cells in the right place while they grow into tissue."

Discher, along wi
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. CWRU researchers find byproducts of bacteria-causing gum disease incite oral cancer growth
2. Researchers make the invisible visible
3. Researchers look for culprit behind oral health problems in HIV-positive patients
4. Clemson researchers develop sticky nanoparticles to fight heart disease
5. NUS researchers make new discovery of protein as a promising target for treatment of ATC
6. Scripps researchers recommend mobile compression device to prevent DVT after joint surgery
7. No such thing as porn addiction, researchers say
8. LA BioMed researchers report on promising new therapy for devastating genetic disorder
9. NIH-funded researchers use antibody treatment to protect humanized mice from HIV
10. Researchers blend orthopedics, engineering to better repair torn rotator cuffs
11. Researchers discover new hormone receptors to target when treating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers show nuclear stiffness keeps stem cells and cancer cells in place
(Date:12/25/2014)... The short film “Color of Honor” by young ... a true 9/11 hero, Welles Remy Crowther. It has been ... hours of Nuremberg International Short Film Festival and the 8th ... screenwriter and director Luciana Lagana plays the mother of ... husband, Gregory Graham - Graham plays a heroic ...
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Helen ... home in Woodland Hills, California after an 8 year ... away on Christmas Eve evening in her home in ... aggressive metastatic breast cancer. , As ... over forty years, she pioneered and championed many of ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 (HealthDay ... receive effective, less expensive care from a clinic that functions ... of dedicated health care professionals, a new study shows. ... either hospitalization or a trip to the emergency room when ... the University of Texas in Houston versus usual care, according ...
(Date:12/25/2014)... News) -- Among early stage breast cancer patients who ... one percent will eventually develop leukemia as a result ... finding comes from a review of more than 20,000 ... it suggests that the risk for developing treatment-related leukemia, ... thought. "The frequency of bone marrow cancers such ...
(Date:12/25/2014)... Thousands of transvaginal mesh lawsuits ( ... number of multidistrict litigations currently underway in U.S. District ... reports. According to an Order issued on December 2, ... Status Conference in all of the proceedings on January ... to submit a proposed agenda to the Court by ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4
... from the University of Georgia and the Mayo Clinic in ... a mouse model that mimics 90 percent of human breast ... treatments. The vaccine, described this week in ... National Academy of Sciences , reveals a promising new strategy ...
... Researchers from the University of Maryland School of Medicine and ... exercise and computerized memory training to see if those activities ... type of memory that will be examined is known as ... use it in a new way. Many Parkinson,s ...
... cancer cells, scientists at Johns Hopkins have found that a ... ability of pre-leukemic cells to repair broken bits of their ... their experiments, expected to be presented at the 53rd Annual ... Dec. 12, have already prompted clinical trials of the drugs ...
... finds that patients who are moved into isolation during a ... a potentially dangerous change in mental status that often affects ... not at increased risk. The study, published in the ... the journal of the Society for Healthcare Epidemiology of America, ...
... have discovered a new way to target cancer through manipulating ... The findings, published today [12 Dec] in the journal ... producing their own blood vessels. Cancer cells gain ... vessels grow, helping deliver oxygen and sugars to the tumour. ...
... MONDAY, Dec. 12 (HealthDay News) -- An advisory panel to the ... Evra birth control patch carries a higher risk of blood clots ... off drug store shelves. The panel, which based its decision ... 19 to 5 that the benefits of Johnson & Johnson,s Ortho ...
Cached Medicine News:Health News:Scientists develop vaccine that attacks breast cancer in mice 2Health News:Scientists develop vaccine that attacks breast cancer in mice 3Health News:Scientists develop vaccine that attacks breast cancer in mice 4Health News:Exercise/memory research for Parkinson's 2Health News:Exercise/memory research for Parkinson's 3Health News:'PARP' drug sabotages DNA repair in pre-leukemic cells 2Health News:'PARP' drug sabotages DNA repair in pre-leukemic cells 3Health News:Patient isolation associated with hospital delirium: study 2Health News:Scientists discover new way to target cancer 2Health News:FDA Panel Cites Clot Risk From Contraceptive Patch 2
(Date:12/24/2014)... 23, 2014 ResMed (NYSE: RMD ) ... against Chinese medical device manufacturer BMC Medical Co., Ltd. ... BMC,s masks listed below infringe ResMed,s patents, and entered an ... in the United States : ... , Willow nasal pillows mask , iVolve full ...
(Date:12/24/2014)... , Dec. 23, 2014  The American ... blood pressure target for people with diabetes and ... or high doses of statins, in keeping with ... enacted by the American College of Cardiology (ACC) ... reflected in the most recent changes to the ...
(Date:12/22/2014)... 2014  CytoSorbents Corporation (OTCQB:CTSOD), a critical care ... technology to help fight deadly inflammation in critically-ill ... today announced the appointment of Dr. Gregory ... Senior Vice President of Clinical Development, effective January ... Russo is an accomplished pediatric cardiothoracic surgeon ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... 7, 2010 Where do you start when trying to ... ), an independent nonprofit that researches the best approaches to ... release of its 5th annual list of Top 10 ... free download with registration, the list features the ...
... Research Group (MRG), the global authority on medical technology ... the US clot management device market.   ... report provides important insight into the device-based treatments ... of medical device manufacturers in this field. The report ...
Cached Medicine Technology:ECRI Institute Releases 'Top 10 Health Technology Hazards for 2011' 2ECRI Institute Releases 'Top 10 Health Technology Hazards for 2011' 3Millennium Research Group to Release Their Latest US Clot Management Data 2
... purpose incubators designed to provide ... uniformity required for the most ... microprocessor controlled incubators feature push-button ... digital display, and built-in over-temperature ...
... available in five different models. Choose mechanical ... Ft. (39 liters), 2.5 cu. Ft. (71.5 ... Equally important, Precision Economy Incubators combine a ... stability, and uniformity. As a result, you ...
Aspheric diagnostic lens. 90D...
Binocular indirect ophthalmic lenses. General diagnosis & treatment....
Medicine Products: