Navigation Links
Penn researchers pinpoint the brain waves that distinguish false memories from real ones
Date:10/23/2007

PHILADELPHIA - For the first time, researchers at the University of Pennsylvania are able to pinpoint brain waves that distinguish true from false memories, providing a better understanding of how memory works and creating a new strategy to help epilepsy patients retain cognitive function.

The study, the first to show that brain waves predict the veracity of human memories, is available online in the journal Psychological Science and in the November 2007 print edition.

To test whether distinct patterns of electrophysiological activity prior to a response can distinguish true from false memories, psychologists at Penn recorded brain activity from 52 neurosurgical patients being treated for drug-resistant epilepsy. Patients were asked to perform a verbal free-recall task while researchers used an array of implanted electrodes and intracranial electroencephalographic recordings to locate where in their brains the patients seizures originated. Patients volunteered to study lists of words which they were then asked to recall at a later time. When asked to recall the studied words, participants recalled some number of correct items and also made a small number of errors, recalling words that had not appeared on the target list.

While patients performed the memory game, scientists observed electrical activity in their brains to determine whether specific brain waves were associated with successfully storing and retrieving memories. Researchers found that a fast brain wave, known as the gamma rhythm, increased when participants studied a word that they would later recall. The same gamma waves, whose voltage rises and fall between 50 and 100 times per second, also increased in the half-second prior to participants correctly recalling an item.

These analyses revealed that the same pattern of gamma band oscillatory activity in the hippocampus, prefrontal cortex and left temporal lobe that predicts successful memory formation also re-emerged at retrieval, distinguishing correct from incorrect responses, said Per B. Sederberg, lead author and former Penn neuroscientist now performing post-doctoral research at Princeton University. The timing of these oscillatory effects suggests that self-cued memory retrieval initiates in the hippocampus and then spreads to the cortex. Thus, retrieval of true as compared with false memories induces a distinct pattern of gamma oscillations, possibly reflecting recollection of contextual information associated with past experience.

Gamma waves actually predicted whether or not an item that was about to be recalled was previously studied, said Michael Kahana, a professor of psychology in Penns School of Arts and Sciences and lead investigator. In other words, one could see a difference in brain activity just prior to remembering something that had and had not actually happened.

In addition to providing a better understanding of how memory works, the findings may also provide a clearer picture of how to assist those suffering with epilepsy. In epilepsy's 2.6 million American sufferers, brain oscillations become so strong that they sweep across the brain, producing seizures. Although seizures are controlled with medication in two-thirds of people with epilepsy, the remainder may be candidates for surgery to remove the brain regions where seizures originate.

Identifying the neural signatures of successful memory storage and retrieval can help neurosurgeons reduce the cognitive deficits that might result from epilepsy surgery, said Brian Litt, associate professor of neurology and bioengineering at Penn, and a co-author of the study.

In addition, these techniques for mapping cognitive networks could give rise to better ways of mapping functional networks in brain, which may help in treating a number of neurological disorders, including depression, schizophrenia, head trauma and affective disorders, Litt said.


'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers identify the early makers of Neonatal Sepsis
4. OHSU Researchers Announce New Discovery
5. Researchers Identify Gene Connected To Bipolar Disorder
6. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
7. Researchers trick Alzheimers Enzyme
8. Researchers find new HIV hiding place
9. Gene researchers make Malaria-resistant mosquito
10. New Hair in 15 Days Could Now Be A Possibility Say Researchers
11. Researchers developed world’s smallest toothbrus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
Breaking Medicine Technology: