Navigation Links
Penn researchers identify the roots of memory impairment resulting from sleep deprivation
Date:5/17/2011

PHILADELPHIA From high-school students to surgeons, anyone who has pulled an all-nighter knows there is a price to be paid the next day: trouble focusing, a fuzzy memory and other cognitive impairments. Now, researchers at Penn have found the part of the brain and the neurochemical basis for sleep deprivation's effects on memory.

Ted Abel, a professor of biology in Penn's School of Arts and Sciences and director of the University's interdisciplinary Biological Basis of Behavior program, led the research team. His partners included Cdrick Florian, a postdoctoral fellow in biology, and Christopher Vecsey, a neuroscience graduate student, as well as researchers from the Massachusetts Institute of Technology and Tufts University.

Their research was published in The Journal of Neuroscience.

Abel's group aimed to better understand the role of the nucleoside adenosine in the hippocampus, the part of the brain associated with memory function.

"For a long time, researchers have known that sleep deprivation results in increased levels of adenosine in the brain, and has this effect from fruit flies to mice to humans." Abel said. "There is accumulating evidence that this adenosine is really the source of a number of the deficits and impact of sleep deprivation, including memory loss and attention deficits. One thing that underscores that evidence is that caffeine is a drug that blocks the effects of adenosine, so we sometimes refer to this as 'the Starbucks experiment.'"

Abel's research actually involved two parallel experiments on sleep-deprived mice, designed to test adenosine's involvement in memory impairment in different ways.

One experiment involved genetically engineered mice. These mice were missing a gene involved in the production of glial transmitters, chemicals signals that originate from glia, the brain cells that support the function of neurons. Without these gliatransmitters, the engineered m
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... ... August 31, 2015 , ... The acknowledgement from Caribbean Journal comes after Grace ... 2015. The island of Providenciales itself received a TripAdvisor Traveller's Choice Award in ... Bay is offering a special promotion for newlyweds and honeymooners to celebrate this amazing ...
(Date:8/30/2015)... ... August 31, 2015 , ... Although middle ... tax receipts, issues that are critically important to them are often overlooked when ... lobbyists monitoring proposed legislation and changing tax and regulatory policies. Smaller companies, which ...
(Date:8/30/2015)... , ... August 31, 2015 , ... Negotiating an FDA ... 1:30 p.m. – 3:00 p.m. EDT, http://www.fdanews.com/importholdcrisis , US authorities are holding ... products, and imports from India. , With alerts on an uptick and a new ...
(Date:8/30/2015)... ... August 31, 2015 , ... Intellitec ... Annual Convention & Expo October 5th & 6th in San Antonio, TX. Dedicated ... convention brings industry professionals from all over the country come to share the ...
(Date:8/30/2015)... ... 31, 2015 , ... ChopChop Kids, the nonprofit publisher of ... elected two new officers to serve on the organization’s Board of Directors in ... teaching kids to cook real food with their families and help continue to ...
Breaking Medicine News(10 mins):Health News:Grace Bay Beach Named a Top Beach Destination for Weddings 2Health News:Newport Board Group, an Advisory Firm Serving the Middle Market, Issues Five Tips on Selling Services to the Government 2Health News:Newport Board Group, an Advisory Firm Serving the Middle Market, Issues Five Tips on Selling Services to the Government 3Health News:Newport Board Group, an Advisory Firm Serving the Middle Market, Issues Five Tips on Selling Services to the Government 4Health News:FDAnews Announces — Negotiating an FDA Import Hold Crisis: Strategies for Challenging FDA Findings Webinar, Sept. 22, 2015 2Health News:FDAnews Announces — Negotiating an FDA Import Hold Crisis: Strategies for Challenging FDA Findings Webinar, Sept. 22, 2015 3Health News:Intellitec Solutions to feature Microsoft Dynamics GP at AHCA/NCAL 66th Annual Convention & Expo 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 3
... will soon have the opportunity to take part in ... the autoimmune disease, ankylosing spondylitis. Approximately 200 patients will ... aims to merge the latest molecular discoveries published by ... medical expertise of physicians and researchers at West China ...
... glaucoma and other conditions , , ... times a day can be difficult for patients to do, and because ... the dose is actually absorbed by the eye. Now, researchers led by ... Delivery at Children,s Hospital Boston, have developed special contact lenses that can ...
... , , , ... Allscripts (Nasdaq: MDRX ), the leader in software, ... Medfusion, the leader in patient-to-provider online communication solutions, today announced ... for Allscripts Electronic Health Record (EHR) and Practice Management clients ...
... 21 /PRNewswire-USNewswire / -- Representatives from leading national ... to honor the 2009 winners of the National Family ... and MetLife Foundation. The event recognized community-based programs supporting ... responsiveness to caregiver needs. , ...
... they,d prefer more flex time and balance in life, , TUESDAY, ... all again, most female surgeons would choose the same career path, ... in the July issue of Archives of Surgery , revealed ... because of their rigorous training and work schedule. , Few female ...
... combined with air pollution, smoking, it raises chances of condition, ... pollution from cars can increase a child,s chances of developing ... get even higher, a new study finds. , For children ... risk, parental stress also increases the risk for asthma, the ...
Cached Medicine News:Health News:Study aims to induce recovery from ankylosing spondylitis 2Health News:A Drug-Dispensing Contact Lens 2Health News:A Drug-Dispensing Contact Lens 3Health News:Allscripts and Medfusion Partner to Provide Patient Portal to Physician Practices Nationwide 2Health News:Allscripts and Medfusion Partner to Provide Patient Portal to Physician Practices Nationwide 3Health News:Allscripts and Medfusion Partner to Provide Patient Portal to Physician Practices Nationwide 4Health News:The National Alliance for Caregiving and MetLife Foundation Honor Innovators Making a Difference in the Lives of Caregivers 2Health News:The National Alliance for Caregiving and MetLife Foundation Honor Innovators Making a Difference in the Lives of Caregivers 3Health News:The National Alliance for Caregiving and MetLife Foundation Honor Innovators Making a Difference in the Lives of Caregivers 4Health News:The National Alliance for Caregiving and MetLife Foundation Honor Innovators Making a Difference in the Lives of Caregivers 5Health News:Female Surgeons Like What They Do, Survey Finds 2Health News:Parental Stress Boosts Kids' Asthma Risk 2Health News:Parental Stress Boosts Kids' Asthma Risk 3
(Date:8/30/2015)... 31, 2015 Noser Health ... to deliver new platform ... citizen-owned health data transaction platform, announced today strategic partnerships ... to engineer and bring to market its global health ... "Our business model is built on trust, ...
(Date:8/30/2015)... August 30, 2015 La ... l cuidado al paciente ...   Royal Philips  (NYSE: PHG, ... IntelliSpace Cardiovascular , un sistema web de gestión ... acceder, analizar y compartir imágenes cardiovasculares e información en ...
(Date:8/29/2015)... y LONDRES, August 29, 2015 ... para los sistemas de imagen por Ultrasonidos ... Ecografía, tiempos de examen rápidos y un flujo de ... confianza diagnóstica en el proceso de detección de Cardiopatías ... PHIA) ha anunciado hoy el lanzamiento europeo de ...
Breaking Medicine Technology:healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 2healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 3healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 4Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 2Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 2Philips presenta HeartModel A.I en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 4Philips presenta HeartModel A.I en el Congreso ESC 2015 5
... Inc. (NYSE: PFE ) today announced ... Innovation, an entrepreneurial network of partnerships with leading ... by accessing leading translational researchers.  The University of ... the network. (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO) ...
... 16, 2010 Baxa Corporation , a leading ... operations, today announced significant upgrades to its DoseEdge ... workflow management tool that verifies the use of correct ... chemo, TPN and oral liquid doses.  This release includes ...
Cached Medicine Technology:Pfizer Launches Global Centers for Therapeutic Innovation, a Network of Research Partnerships, With University of California, San Francisco 2Pfizer Launches Global Centers for Therapeutic Innovation, a Network of Research Partnerships, With University of California, San Francisco 3Pfizer Launches Global Centers for Therapeutic Innovation, a Network of Research Partnerships, With University of California, San Francisco 4Baxa Releases Upgrade for DoseEdge™ - the Only Dose Management System With Comprehensive Formulary Management Functionality 2Baxa Releases Upgrade for DoseEdge™ - the Only Dose Management System With Comprehensive Formulary Management Functionality 3Baxa Releases Upgrade for DoseEdge™ - the Only Dose Management System With Comprehensive Formulary Management Functionality 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: