Navigation Links
Penn researchers identify the roots of memory impairment resulting from sleep deprivation
Date:5/17/2011

PHILADELPHIA From high-school students to surgeons, anyone who has pulled an all-nighter knows there is a price to be paid the next day: trouble focusing, a fuzzy memory and other cognitive impairments. Now, researchers at Penn have found the part of the brain and the neurochemical basis for sleep deprivation's effects on memory.

Ted Abel, a professor of biology in Penn's School of Arts and Sciences and director of the University's interdisciplinary Biological Basis of Behavior program, led the research team. His partners included Cdrick Florian, a postdoctoral fellow in biology, and Christopher Vecsey, a neuroscience graduate student, as well as researchers from the Massachusetts Institute of Technology and Tufts University.

Their research was published in The Journal of Neuroscience.

Abel's group aimed to better understand the role of the nucleoside adenosine in the hippocampus, the part of the brain associated with memory function.

"For a long time, researchers have known that sleep deprivation results in increased levels of adenosine in the brain, and has this effect from fruit flies to mice to humans." Abel said. "There is accumulating evidence that this adenosine is really the source of a number of the deficits and impact of sleep deprivation, including memory loss and attention deficits. One thing that underscores that evidence is that caffeine is a drug that blocks the effects of adenosine, so we sometimes refer to this as 'the Starbucks experiment.'"

Abel's research actually involved two parallel experiments on sleep-deprived mice, designed to test adenosine's involvement in memory impairment in different ways.

One experiment involved genetically engineered mice. These mice were missing a gene involved in the production of glial transmitters, chemicals signals that originate from glia, the brain cells that support the function of neurons. Without these gliatransmitters, the engineered m
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... On April 16, 2015, Harper’s Bazaar Magazine, in ... Marks ,” interviewed a UK dermatologist on the causes and ... are a type of scar that reportedly affects nearly 90% ... of the elsastin and collagen in the dermis, the dense ... mark removal with the Coolbeam protocol is one of our ...
(Date:4/27/2015)... 2015 Beckman Coulter is sponsoring a ... study the evolution of neural circuitry and swimming behavior ... the mechanisms by which analogous forms of swimming behavior, ... evolved independently in certain sea slug clades. The webinar ... April 30, 2015 at 8:00am PT. , Sea slugs ...
(Date:4/27/2015)... Humble, TX (PRWEB) April 27, 2015 Sitting ... legs to ache and feel tired, and for those whose ... such as receptionists and taxi cab drivers, or to be ... teachers and hairdressers, the discomfort can be more severe and ... tired, achy leg syndrome. Dr. Madaiah Revana of Northeast Houston ...
(Date:4/27/2015)... PA (PRWEB) April 27, 2015 FMC ... will exhibit its wide range of market leading ingredients ... May 7 in Geneva, Switzerland. Vitafoods Europe 2015 expects ... 100 countries showcasing the latest research in such areas ... nutrition. , FMC Health and Nutrition’s booth will ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 Telematics Berlin ... tier 1&2 suppliers, associations, CE players and the government ... has opened to the car. This year’s panel on ... DG-Move at the European Commission, is an opportunity to ... and define a European Automotive Security Standard for years ...
Breaking Medicine News(10 mins):Health News:Stretch Marks: The Latest Treatment Options for Stretch Mark Removal 2Health News:Beckman Coulter Genomics Presents Using Next-Gen Sequencing to Study the Evolution of Neural Circuitry 2Health News:Beckman Coulter Genomics Presents Using Next-Gen Sequencing to Study the Evolution of Neural Circuitry 3Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 2Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 3Health News:FMC Health and Nutrition to Feature Epax® Brand Omega-3 Ingredients at Vitafoods Europe 2015 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 3
... 25 Smart Balance Inc.,(Nasdaq: SMBL ) will ... on Wednesday, May 21, 2008, at the Teaneck Marriott ... 07666. Stockholders of record,at the close of business on ... all matters that properly come before the meeting., ...
... passed the Genetic Information Nondiscrimination Act (GINA) on April 24, ... which passed the House April 25, 2007 by a vote ... measure again quickly before sending it to President Bush to ... wait, Americans can now be confident that their genetic information ...
... A Johns Hopkins University biologist, in research with implications ... has determined that the eye uses light to reset ... ability to see. , The findings suggest that patients ... can be linked to lack of exposure to daylight ...
... InfoLogix, Inc.,(Nasdaq: IFLG ), a leading technology ... commercial industries, will release its,financial results for the ... 30th, 2008. Following the press release, President and ... Jay Roberts will,host a conference call with the ...
... had less blood loss, shorter hospital stays, study finds ... laparoscopic surgery to remove pancreatic tumors or cysts leads ... study finds. , In laparoscopic surgery, doctors make ... progress with fiber optics and video cameras. This less ...
... (OTC Bulletin,Board: NTRZ), a world leader in stabilized ... that it has entered into,definitive agreements to sell ... of $20,000,000. The offering is made,pursuant to the ... by,NutraCea with the Securities and Exchange Commission (the ...
Cached Medicine News:Health News:Genetic Information Nondiscrimination Act clears Senate 2Health News:Different processes govern sight, light detection 2Health News:InfoLogix to Report First Quarter Results on April 30, 2008 2Health News:Laparoscopic Surgery on Pancreas Has Fewer Complications 2Health News:NutraCea Announces $20 Million Securities Offering 2Health News:NutraCea Announces $20 Million Securities Offering 3
(Date:4/27/2015)... MILAN , April 27, 2015  USL di ... Italian province of Reggio Emilia, has implemented Zebra ... throughout the hospital. The Wireless Network Solution ... patients, medical records securely and in real time via ... available at all times. Zebra also provides employee and ...
(Date:4/27/2015)... SAN DIEGO , April 27, 2015  Agena Bioscience ... (CSP) for Agena Bioscience,s MassARRAY platform in China ... at unprecedented speed. It is a hotbed for practical, meaningful ... China and for the rest of the world. ... community in China ," said Peter ...
(Date:4/27/2015)... -- China Jo-Jo Drugstores, Inc. (NASDAQ CM: ... leading China-based retail and wholesale distributor that offers pharmaceutical ... pharmacies, today announced its subsidiary, Hangzhou Jiuzhou Grand Pharmacy ... sales incentive agreement with Wyeth Pharmaceutical Company, Ltd. ("Wyeth"), ... of Pfizer Inc. (NYSE: PFE ) (the ...
Breaking Medicine Technology:Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 2Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 3Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 4Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 5Agena Bioscience Names Bioyong Technology as Fifth Certified Service Provider in China 2China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 2China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 3China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 4
... Disease Week ... 2008, ... today that it has initiated the Phase 2 clinical,development program of MDX-1100, ... ulcerative colitis (UC) and,rheumatoid arthritis (RA). MDX-1100 could potentially treat UC and ...
... Thailand, May 9 An emergency,veterinary team from the ... stand-by in Thailand awaiting authority to enter cyclone struck,Myanmar ... of animals,that human survivors depend on for food and ... The Food and Agriculture,Organization of the United Nations (FAO) ...
Cached Medicine Technology:Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 2Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 3Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 4Animals That Cyclone Survivors Depend on Need Help Now 2
Inquire...
Inquire...
Inquire...
The modular, high-end stereomicroscope; meets even the most critical demands in research and quality control provides high-contrast images with excellent depth of field and color fidelity...
Medicine Products: