Navigation Links
Penn researchers identify first sex chromosome gene involved in meiosis and male infertility
Date:3/14/2008

A team of scientists led by University of Pennsylvania veterinary researchers have identified a gene, TEX11, located on the X chromosome, which when disrupted in mice renders the males sterile and reduces female fecundity. This is the first study of the genetic causes of infertility that links a particular sex chromosome meiosis-specific gene to sterility.

As with mice, the TEX11 gene is also located on the human X chromosome. Given that disruption of TEX11 causes azoospermia, or non-measurable sperm levels in mice, mutations in the human TEX11 gene may be a genetic cause of infertility in men. Because men have only one X chromosome that they inherit from their mother and thus only one copy of the TEX11 gene, any mutation could theoretically lead to sterility. Like other X-linked disorders such as color blindness and muscular dystrophy, genetic mutation causing a sons infertility could be passed from his mother.

Researchers hypothesize that a screening of the TEX11 gene may provide a pre-birth diagnosis for infertility in men.

The study, published in the March issue of Genes & Development, also reports the first meiosis-specific factor ever found on the X chromosome. Meiosis is the process of cell division that produces gametes in both sexes. During meiosis, homologous chromosomes undergo pairing, synapsis, recombination and faithful segregation. Meiosis allows the exchange of genetic material between paternal and maternal genomes to produce genetically diverse gametes (sperm or eggs). Therefore, defects in meiosis are a leading cause of both infertility and birth defects.

An estimated 15 percent of couples are affected by infertility worldwide, yet the genetic causes of male infertility remain largely unknown. For decades, conventional wisdom stated that the X chromosome had little to do with meiosis or infertility because the X chromosome is silenced during male meiosis. This thinking led to fertility studies that
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Recently, Skmen.com, a renowned garment manufacturer and retailer, has ... . The company has rich experience in making fashionable ... stock and ready to ship: celebrity bodycon dresses, mini ... and so forth. All of them are available in ... proud to announce the new collection of celebrity bodycon ...
(Date:8/27/2014)... August 27, 2014 Taking its popular obstacle ... Steele Creek YMCA will host its largest crowd at ... Saturday, September 13 at YMCA Camp Thunderbird . ... divisions: adult, youth and teams. Within each division, runners ... their physical limit - for a worthy cause. All ...
(Date:8/27/2014)... 2014 Today, Zane Benefits, the #1 ... tips for administering a premium reimbursement plan. , ... effect, compliance is top of mind for employers, health ... health insurance and premium reimbursement, there are important compliance ... 35 minute webinar, Zane Benefits President, Rick Lindquist, will ...
(Date:8/27/2014)... Skirt Sports , the innovative women’s running apparel ... Kathrine Switzer, most noted for her brave running of the ... of women’s running clothes that unites the history of women’s ... Movement. , “It is such an honor to ... “Kathrine is the original Skirt – she stood strong, pushing ...
(Date:8/27/2014)... the use of hormone therapy has spawned a prevalent ... silence with hot flashes, according to a study by ... , In the study published in the Aug. 27 ... team found that moderate to severe hot flashes ... in most women. Women with VMS experience more than ...
Breaking Medicine News(10 mins):Health News:Skmen.com Unveils Its New Celebrity Bodycon Dresses for Its Loyal Customers 2Health News:C2 Survival Racers Go to Extremes to Provide Kids with YMCA Programs 2Health News:Zane Benefits Announces Upcoming Webinar on Compliance 2Health News:Skirt Sports Launches Clothing Line with Legendary Runner Kathrine Switzer 2Health News:The high cost of hot flashes: Millions in lost wages preventable 2
... Upgrades new facility from film to IDC 1600 ... - IDC (Imaging Dynamics Company,Ltd.) (TSX: IDL), the ... radiography (DR), today announced that HealthPartners Medical Group,of ... X-Series DR system.,HealthPartners is a multi-specialty physician group ...
... a range of $395 Million to $405 Million; ... ... up 57.4% over first quarter 2007 - Gross profit of $23.9 million, ... up 135.4% over first quarter 2007, WARSAW, Ind., June 24 Symmetry Medical ...
... Exposure Increased 38% From 2001 - 2007, ... advertising practices by alcohol companies from 2001-2007,finds an ... relatively,few industry- sponsored "responsibility" ads. The new study, ... Youth (CAMY) at Georgetown,University, evaluated advertising trends and ...
... Research,Inc. (ADR), one of the world,s leading scientific institutes ... to announce that it,has achieved legal status as a ... fully-operational for a while now," says,Dr. Catlin, a founder ... all official and we,re thrilled, because others can now ...
... China, TUSTIN, Calif., June 24 AMDL, ... specialty pharmaceuticals,announced today its subsidiary Jade Pharmaceutical, Inc. ... two new formulations of its,popular Goodnak(R) anti-aging skin ... injectable formulation, JPI anticipates offering Goodnak in,capsules and ...
... ultrasound exam of the heel may be able to predict ... to osteoporosis, according to a new multicenter study being published ... Along with certain risk factors, including age or recent fall, ... select women who need further bone density testing, such as ...
Cached Medicine News:Health News:HealthPartners Medical Group in Michigan City purchases IDC digital radiography system 2Health News:HealthPartners Medical Group in Michigan City purchases IDC digital radiography system 3Health News:Symmetry Medical Reports Record First Quarter 2008 Revenue of $101.9 Million 2Health News:Symmetry Medical Reports Record First Quarter 2008 Revenue of $101.9 Million 3Health News:Symmetry Medical Reports Record First Quarter 2008 Revenue of $101.9 Million 4Health News:Symmetry Medical Reports Record First Quarter 2008 Revenue of $101.9 Million 5Health News:Symmetry Medical Reports Record First Quarter 2008 Revenue of $101.9 Million 6Health News:Symmetry Medical Reports Record First Quarter 2008 Revenue of $101.9 Million 7Health News:Symmetry Medical Reports Record First Quarter 2008 Revenue of $101.9 Million 8Health News:Alcohol Advertisements Seen by Youth on TV on the Rise, According to a New Report by the Center on Alcohol Marketing and Youth 2Health News:Alcohol Advertisements Seen by Youth on TV on the Rise, According to a New Report by the Center on Alcohol Marketing and Youth 3Health News:Leading Performance-Enhancing Drug Research Institute Anti-Doping Research (ADR) Establishes Nonprofit Status 2Health News:AMDL's Goodnak(R) Anti-Aging Skin Care Line Soon Available in Capsule & Lotion Form 2Health News:Simple ultrasound exam may predict osteoporosis risk 2
(Date:8/27/2014)... LONDON , Aug. 27, 2014 /PRNewswire/ ... research report: Collaborative R&D Terms ... https://www.reportbuyer.com/product/2276220/Collaborative-RD-Terms--Agreements-in-Pharma-Biotech-and-Diagnostics.html The ... Biotech and Diagnostics report provides comprehensive understanding ... deals and agreements entered into by the ...
(Date:8/27/2014)... , Aug. 27, 2014 /PRNewswire-iReach/ -- In ... to bridge the gap between the electronic medical ... embedded links, readers can experience, first-hand, how seamless ... record. Photo - http://photos.prnewswire.com/prnh/20140827/140443 ... central access to imaging from within the patient ...
(Date:8/27/2014)... 27, 2014 About 8 million Americans have ... buildup of fatty plaque in the arteries, according to ... population and in incidences of diabetes and obesity, the ... Lower Extremity Arterial RevascularizatioN (LEARN) meeting, Oct. 9–11 ... and interested residents and fellows will be able to ...
Breaking Medicine Technology:Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 4Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 5Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 6Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 7Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 8Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 9DICOM Grid Launches Interactive Guide to Demonstrate Image-Enabling the EMR 2LEARN to Treat Peripheral Arterial Disease Patients 2LEARN to Treat Peripheral Arterial Disease Patients 3
... Essence Orthopaedics, Inc., a medical device company focused on ... has introduced their novel, surgeon-designed PONTiS™ Knotless Endotendonous Repair ... Society for Surgery of the Hand (ASSH). ... upper and lower extremity markets, Core Essence Orthopaedics developed ...
... Optimer Pharmaceuticals (NASDAQ: OPTR ) today ... DIFICID™ (fidaxomicin) tablets will be presented at the 2011 ... place September 17-20 in Chicago. DIFICID was approved by ... of 2011 for the treatment of Clostridium difficile ...
Cached Medicine Technology:Core Essence Orthopaedics Unveiled New Flexor Tendon Repair System at ASSH 2011 2Optimer Pharmaceuticals' DIFICID Featured in 11 Presentations at 51st ICAAC 2Optimer Pharmaceuticals' DIFICID Featured in 11 Presentations at 51st ICAAC 3Optimer Pharmaceuticals' DIFICID Featured in 11 Presentations at 51st ICAAC 4Optimer Pharmaceuticals' DIFICID Featured in 11 Presentations at 51st ICAAC 5
... Pulse Oximeter monitors SpO2, pulse ... is designed to provide fast, ... The device rejects spontaneous motion ... operator of excess artifacts and ...
... Radical can operate in two additional ... be removed, creating a fully featured handheld ... also be used to upgrade existing equipment ... additinal hardware or software upgrades to improve ...
Halogen-free immersion oil based on ester oil....
Immersion Oil, 150 cs...
Medicine Products: